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Disinfectants can make bacteria resistant to treatment
Chemicals used in the environment to kill bacteria could be making them stronger, according to a paper published in the October issue of the journal Microbiology. Low levels of these chemicals, called biocides, can make the potentially lethal bacterium Staphylococcus aureus remove toxic chemicals from the cell even more efficiently, potentially... view more... (2008-10-06)
Stopping unwanted cell death: Implications for drug discovery
Research published in Nature Chemical Biology reveals that three specific inhibitors of a cell death pathway, termed necroptosis, all target and inhibit RIP1 kinase, a protein that can direct cells into necrosis. view more (2008-04-14)
Enzyme inhibitor may provide strategy to treat some GI disorders, Jefferson researchers find
Drugs that block the activity of an enzyme might hold a key to treating chronic and severe disorders such as certain forms of constipation, hemorrhoids, anal fissures, Hirschsprung's disease and other similar gastrointestinal problems. view more (2006-07-19)
NEW DRUG TREATMENT COULD PROVIDE LONG-TERM BENEFIT FOR HEART-ATTACK PATIENTS (p 1385)
Patients with acute myocardial infarction (heart attack), complicated by left-ventricular systolic dysfunction, could benefit from the ß-blocker carvedilol, conclude authors of a study in this week's issue of THE LANCET. In a randomised, placebo-controlled trial, this drug reduced the frequency of death from all causes, death from... view more... (2001-05-03)
New information points to safer methadone use for treatment of pain and addiction
New findings may significantly improve the safety of methadone, a drug widely used to treat cancer pain and addiction to heroin and other opioid drugs, according to researchers at Washington University School of Medicine in St. Louis and the University of Washington in Seattle. view more (2009-03-03)
Use of acid-suppressive medications associated with increased risk of hospital-acquired pneumonia
Hospitalized patients who receive acid-suppressive medications such as a proton-pump inhibitor have a 30 percent increased odds of developing pneumonia while in the hospital. view more (2009-05-27)
Aminoguanidine: An attractive line as a multi-modal avenue to overcome tumor
Aminoguanidine is a compound that exerts multiple biological actions. Aminoguanidine has well described antioxidant properties and is also an inhibitor of nitric oxide synthases, the enzymes that produce nitric oxide. view more (2009-03-09)
Novel enzyme inhibitor paves way for new cancer drug
Combining natural organic atoms with metal complexes, scientists at The Wistar Institute have developed a new type of enzyme inhibitor capable of blocking a biochemical pathway that plays a key role in cancer development. view more (2008-05-16)
Researchers Debate Recreational Use of PDE-5 Inhibitors
Leaders in the field of sexual medicine will actively debate the use of oral pills for erectile dysfunction (ED) at the 7th Congress of the European Society for Sexual Medicine in London, UK. view more (2004-12-01)
Van Andel Institute Study Rules Out Transcriptional Coactivators as Useful Herpes Antiviral Drug Targets
Researchers at Van Andel Research Institute (VARI) have determined that the herpes simplex virus type 1 (HSV-1) does not require transcriptional coactivators for viral gene expression early in the infection process. The finding is significant in determining that, in contradiction to earlier models, chemical inhibitors of these cellular proteins... view more... (2009-03-26)
LOWER TEEN PREGNANCY RATES IN PRACTICES WITH YOUNG FEMALE DOCTORS
Hippisley-Cox and colleagues, from the Division of General Practice, University of Nottingham, looked at the numbers of teen pregnancies for each of the 826 general practices in the Trent region between 1994 and 1997. The Trent region has one of the highest teen pregnancy rates in the UK. view more (2000-03-21)
Researchers make discovery in colon cancer prevention
A new study finds that individuals who have low expression of the "Celebrex gene," 15-PGDH, are actually resistant to Celebrex treatment when used to prevent colon cancer. view more (2009-05-19)
Organic & Biomolecular Chemistry
First Advance Articles Now Available Free Online The first issue of Organic & Biomolecular Chemistry, formed from the merger and strategic development of Perkin Transactions 1 & 2, will be published on 10 January 2003. The electronic version will go up on 23 December 2002. Barbara Imperiali, Francois Diederich, Ben Feringa and Chi-Huey... view more... (2002-12-05)
Low-dose aspirin reduces cardiovascular events
Taking low-dose aspirin daily reduces the risk of heart attack and stroke, as well as the risk of dying, among patients who previously have had a heart attack or stroke but whose cardiovascular disease has stabilized. view more (2006-11-16)
Penn studies point to strategies for reducing painful breast cancer drug side effects
Aromatase inhibitors, the same drugs that have buoyed long-term survival rates among breast cancer patients, also carry side effects including joint pain so severe that many patients discontinue these lifesaving medicines. view more (2009-09-29)
Rheumatoid arthritis factors equal to cardiovascular factors in risk of severe cardiovascular events
Certain cardiovascular disease (CVD) risk factors and rheumatoid arthritis (RA) disease factors have a similar effect on an RA patient's risk of experiencing myocardial infarction (MI) or stroke. view more (2008-06-16)
Drug discovery process more accurate, less expensive using novel mass spectrometry application
Cancer and cell biology experts at the University of Cincinnati (UC) have developed a new mass spectrometry-based tool they say provides more precise, cost-effective data collection for drug discovery efforts. view more (2009-09-18)
U-M researchers discover gene switched off in cancer can be turned on
A gene implicated in the development of cancer cells can be switched on using drugs, report researchers from the University of Michigan Comprehensive Cancer Center. view more (2007-06-12)
Experimental drug shows promise against head and neck cancer
A laboratory study by researchers at Albert Einstein College of Medicine of Yeshiva University suggests that an anti-cancer compound studied for treating blood cancers may also help in treating cancers of the head and neck. The work is reported in the April 28th online edition of the Journal of Pathology. view more (2009-04-29)
Anthrax inhibitor counteracts toxin, may lead to new therapeutics
Researchers from Rensselaer Polytechnic Institute and the University of Toronto have designed a nanoscale assembly of molecules that successfully counteracts and inhibits anthrax toxin in animal and laboratory experiments. view more (2006-04-24)
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