Scripps Research Institute Scientists Find the Structure of a Key 'Gene Silencer' Protein
Scientists at The Scripps Research Institute have determined the three-dimensional atomic structure of a human protein that is centrally involved in regulating the activities of cells. View More (2012-04-27)
Discovery Provides Blueprint for New Drugs That Can Inhibit Hepatitis C Virus
Chemists at the University of California, San Diego have produced the first high resolution structure of a molecule that when attached to the genetic material of the hepatitis C virus prevents it from reproducing. View More (2012-03-20)
Semi-automated 'pathwalking' to build a protein model
A new semi-automated tool called pathwalking makes it possible to generate a "first draft" model of a protein fold taken from near-atomic resolution images of between three and six angstroms. View More (2012-03-07)
Mayo researchers provide atomic view of a histone chaperone
Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. View More (2012-03-02)
Solving mystery of how sulfa drugs kill bacteria yields 21st century drug development target
More than 70 years after the first sulfa drugs helped to revolutionize medical care and save millions of lives, St. Jude Children's Research Hospital scientists have determined at an atomic level the mechanism these medications use to kill bacteria. View More (2012-03-02)
Correct Protein Folding
The gold standard for nanotechnology is nature's own proteins. View More (2012-02-27)
New zeolite material may solve diesel shortage
World fuel consumption is shifting more and more to diesel at the expense of gasoline. A recently published article in Nature Chemistry by a research team at Stockholm University and the Polytechnic University of Valencia in Spain presents a new porous material that evinces unique properties for converting gasoline directly into diesel. View More (2012-02-02)
How cells dispose of their waste
Defective proteins that are not disposed of by the body can cause diseases such as Alzheimer's or Parkinson's. View More (2012-01-24)
Clearing a Potential Road Block to Bisabolane
The recent discovery that bisabolane, a member of the terpene class of chemical compounds used in fragrances and flavorings, holds high promise as a biosynthetic alternative to D2 diesel fuel has generated keen interest in the green energy community and the trucking industry. Now a second team of researchers with the U.S Department of Energy (DOE)'s Joint BioEnergy Institute (JBEI) has determined... View More (2012-01-11)
UC Davis researcher develops model to foster new drug development to treat pain and epilepsy
Drawing on X-ray crystallography and experimental data, as well as a software suite for predicting and designing protein structures, a UC Davis School of Medicine researcher has developed an algorithm that predicts what has been impossible to generate in the laboratory: the conformational changes in voltage-gated sodium channels when they are at rest or actively transmitting a signal in muscle... View More (2011-12-13)
Carnegie Mellon Researchers Use NMR to Determine Whether Gold Nanoparticles Exhibit
Carnegie Mellon University's Roberto R. Gil and Rongchao Jin have successfully used NMR to analyze the structure of infinitesimal gold nanoparticles, which could advance the development and use of the tiny particles in drug development. View More (2011-12-09)
Supercomputer reveals new details behind drug-processing protein model
Supercomputer simulations at the Department of Energy's Oak Ridge National Laboratory are giving scientists unprecedented access to a key class of proteins involved in drug detoxification. View More (2011-12-07)
Scripps Research team finds a weak spot on deadly ebolavirus
Scientists from The Scripps Research Institute and the US Army's Medical Research Institute of Infectious Diseases have isolated and analyzed an antibody that neutralizes Sudan virus, a major species of ebolavirus and one of the most dangerous human pathogens. View More (2011-11-21)
DOE laboratories help develop promising new cancer fighting drug, vemurafenib
Powerful X-ray technology developed at the U.S. Department of Energy's (DOE's) national laboratories is revealing new insights into diseases ranging from Alzheimer's to the swine flu, and, most recently, enabled the discovery of a groundbreaking new drug treatment for malignant melanoma, the deadliest form of skin cancer. View More (2011-08-19)
A chaperone system guides tail-anchored membrane proteins to their destined membrane
A newly synthesized protein is as fragile as a newborn baby. It could never fold into its correct three dimensional structure if it was not protected by chaperones within the densely populated cytosol. View More (2011-07-06)
Hitting moving RNA drug targets
By accounting for the floppy, fickle nature of RNA, researchers at the University of Michigan and the University of California, Irvine have developed a new way to search for drugs that target this important molecule. View More (2011-06-27)
Lasers used to form 3-D crystals made of nanoparticles
University of Michigan physicists used the electric fields generated by intersecting laser beams to trap and manipulate thousands of microscopic plastic spheres, thereby creating 3-D arrays of optically induced crystals. View More (2011-06-01)
Understanding a bacterial immune system 1 step at a time
Researchers at the University of Alberta have taken an important step in understanding an immune system of bacteria, a finding that could have implications for medical care and both the pharmaceutical and dairy industries. View More (2011-05-18)
Several baffling puzzles in protein molecular structure solved with new method
The structures of many protein molecules remain unsolved even after experts apply an extensive array of approaches. View More (2011-05-02)
Bacteria interrupted: Disabling coordinated behavior and virulence gene expression
New research reveals a strategy for disrupting the ability of bacteria to communicate and coordinate the expression of virulence factors. View More (2011-04-22)
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