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Nanoscale microscope sheds first light on gene repair
Proteins called H2AX act as "first aid" to DNA, among other roles. For the first time, scientists using the world's most powerful light microscope (the only one of its kind in the Americas) have seen how H2AX is distributed in the cell nucleus: in clusters, directing the first aid/repair after DNA injuries to the region where it is... view more... (2006-11-14)
Nanopore Method Could Revolutionize Genome Sequencing
A team led by physicists at the University of California, San Diego has shown the feasibility of a fast, inexpensive technique to sequence DNA as it passes through tiny pores. The advance brings personalized, genome-based medicine closer to reality. view more (2006-04-07)
Mayo Clinic collaboration discovers protein amplifies DNA injury signals
A Mayo Clinic-led research collaboration has discovered that the protein MDC1 amplifies weak DNA injury signals so genetic repair can begin. view more (2006-01-20)
Protein splicing upsets the DNA colinearity paradigm
Understanding medical research problems often relies on the direct, linear relationship between the sequence of a protein and the DNA encoding that protein. view more (2006-09-08)
Sisyphean movement of motor proteins may help preserve DNA integrity
Researchers studying how proteins called helicases travel along strands of DNA have found that when the proteins hit an obstacle they snap back to where they began, repeating the process over and over, possibly playing a preventative role in keeping the genome intact. view more (2005-10-27)
Does evolution select for faster evolvers?
It's a mystery why the speed and complexity of evolution appear to increase with time. For example, the fossil record indicates that single-celled life first appeared about 3.5 billion years ago, and it then took about 2.5 billion more years for multi-cellular life to evolve. view more (2007-01-30)
Faulty cell cycle checkpoints linked to lung cancer risk in African-Americans
Faulty cell cycle "checkpoints" that fail to respond to DNA damage effectively may contribute to the high incidence of lung cancer in African-Americans. view more (2005-10-17)
CU researchers announce new technique for rapidly detecting illness-causing bacteria in food
Cornell University scientists have developed a rapid, less costly and sensitive new technique for detecting group A streptococcus, the bacteria that cause scarlet fever. Details will be announced today at the Institute of Food Technologists Annual Meeting and Food Expo in New Orleans. view more (2005-07-19)
Evidence of rapid evolution is found at the tips of chromosomes
In terms of their telomeres, mice are more complicated than humans. That's the finding from a recent Rockefeller University study, which shows that mice have two proteins working together to do the job of a single protein in human cells. view more (2006-08-02)
University of Minnesota researchers take new look at cellular suicide
Like a bodyguard turned traitor, a protein whose regular job is to help repair severed DNA molecules will, in some cases, join forces with another protein to do the opposite and chop the DNA to bits. view more (2006-07-07)
CSH Protocols publishes cutting-edge methods for analyzing complex molecular interactions
With the genomes of hundreds of organisms now catalogued, one of the next major challenges is to identify proteins and their interactions. view more (2006-10-05)
Mars meteorite similar to bacteria-etched earth rocks
A new study of a meteorite that originated from Mars has revealed a series of microscopic tunnels that are similar in size, shape and distribution to tracks left on Earth rocks by feeding bacteria. view more (2006-03-24)
DNA constraints control structure of attached macromolecules
A new method for manipulating macromolecules has been developed by researchers at the University of Illinois at Urbana-Champaign. The technique uses double-stranded DNA to direct the behavior of other molecules. view more (2005-06-29)
Study finds value in 'junk' DNA
For about 15 years, scientists have known that certain "junk" DNA -- repetitive DNA segments previously thought to have no function -- could evolve into exons, which are the building blocks for protein-coding genes in higher organisms like animals and plants. view more (2008-10-17)
Researchers Create DNA-Based Sensors for Nano-Tongues and Nano-Noses
Nano-sized carbon tubes coated with strands of DNA can create tiny sensors with abilities to detect odors and tastes, according to researchers at the University of Pennsylvania and Monell Chemical Sciences Center. view more (2005-09-16)
Detection of Salmonella in 24 hours
The food and drink we consume have to pass strict quality controls. Nevertheless, these measures are not always sufficient, given that sometimes certain foodstuffs can still give rise to food poisoning, most often caused by micro-organisms. view more (2007-02-09)
In a crisis, creating DNA vaccine could help save lives, slow spread of 'bird flu'
Researchers scrambling to combat a virulent form of bird flu that could mutate into a form easily spread among humans should consider developing vaccines based on DNA, according to British biochemical engineers. view more (2005-10-20)
Assessment model gauges lung cancer risk based on medical history and genetics
Physicians have little to help them predict development of lung cancer in their patients-even a history of heavy smoking doesn't really help, since only a small fraction of lifetime smokers develops the cancer. view more (2006-04-05)
Change in gene may be underlying molecular defect in some colorectal cancers, study suggests
Inactivation of a DNA repair gene may be an early step in the development of sporadic colorectal tumors, and detection of the molecular basis for this inactivation may ultimately be useful in risk assessment for colorectal cancer. view more (2005-09-21)
Mitochondrial DNA sequencing tool updated
High-tech laboratory tools, like computers, are often updated publicly as their analytical capabilities expand. In the September issue of the Journal of Molecular Diagnostics, NIH grantees report they have developed a second generation "lab on a silicon chip" called the MitoChip v2.0 that for the first time rapidly and reliably sequences... view more... (2006-08-28)
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