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DNA Repair News | DNA Repair Current Events
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Cash boost for research into leukaemia
Scientists from the University of Sussex in Brighton have been awarded £147,000 by the Leukaemia Research Fund (LRF) to look at abnormalities in DNA damage and repair that occur in some leukaemias and lymphomas. The research team ¾ led by Dr Penny Jeggo at the Genome Damage and Stability... view more (2002-09-11)

DNA repair mechanisms are concentrated in the active parts of the genome
Less than 10% of the human genome contains coded information in the form of genes. The 30,000-40,000 genes in the genome are found grouped in discrete regions of the chromosomes. Chemical agents and radiation habitually cause a large variety of injuries to the DNA which interferes in many cell... view more (2002-10-01)

Gene for neat repair of DNA discovered
Researchers from the Erasmus University in Rotterdam have demonstrated that a gene helps in the neat repair of DNA. Without this gene the body would repair damaged DNA in a careless manner more often. This causes new damage, which can lead to cancer. The careless repair of damaged DNA can cause... view more (2002-01-24)

Fewer complications with laparoscopic hernia repair
Laparoscopic hernia repair results in fewer long term complications than open repair surgery, finds a study in this week’s BMJ.   view more (2003-05-07)

Once suspect protein found to promote DNA repair, prevent cancer
An abundant chromosomal protein that binds to damaged DNA prevents cancer development by enhancing DNA repair, researchers at The University of Texas M. D. Anderson Cancer Center report online this week in the Proceedings of the National Academies of Science.   view more (2008-07-22)

Faulty DNA repair could be a risk factor for lung cancer in nonsmokers
People who have never smoked but whose cells cannot efficiently repair environmental insults to DNA are at higher risk of developing lung cancer than those with effective genomic repair capability.   view more (2008-06-26)

Scientists identify specific enzymes that make meningitis hard to fight
Two enzymes in meningitis bacteria which prevent the body from successfully fighting off the disease, and make the infection extremely virulent, have been identified in new research published today.   view more (2007-02-23)

Dartmouth study finds that arsenic inhibits DNA repair
Dartmouth researchers, working with scientists at the University of Arizona and at the Department of Natural Resources in Sonora, Mexico, have published a study on the impact of arsenic exposure on DNA damage.   view more (2006-05-30)

Chromosome glue repairs damaged DNA
When a strand of DNA breaks in the body's cells, it normally does not take long until it has been repaired. Now researchers at the Swedish medical university Karolinska Institutet have discovered a new mechanism that helps to explain how the cell performs these repairs. The results are presented in... view more (2007-07-16)

2 heads are better than 1: 2 dysfunctional DNA repair pathways kill tumor cells
Individuals who inherit two mutant copies of any one of about 12 genes that make the proteins of the Fanconi Anemia (FA) pathway develop FA, which is characterized by increased incidence of cancer and bone marrow failure, among other things.   view more (2007-04-13)

Mayo Clinic discovers DNA repair as key to Huntington's disease
Mayo Clinic researchers, along with collaborators from the National Institutes of Health (NIH) and University of Oslo, Norway, have discovered that a miscue of the body's genetic repair system may cause Huntington's disease, a fatal condition that affects 30,000 Americans annually by destroying... view more (2007-04-23)

Normal chromosome ends elicit a limited DNA damage response
Researchers at the Salk Institute for Biological Studies discovered that cells co-opted the machinery that usually repairs broken strands of DNA to protect the integrity of chromosomes.   view more (2005-11-28)

Chromatin remodeling complex connected to DNA damage control
When molecular disaster strikes, causing structural damage to DNA, players in two important pathways talk to each other to help contain the wreckage, scientists at The University of Texas M. D. Anderson Cancer Center report in the August edition of Cell.   view more (2007-08-10)

Enzyme crystal structure reveals 'unexpected' genome repair functions
The research looked at XPB helicase from an archaea, a single cell organism similar to bacteria. Helicases are enzymes that unwind or separate the strands of the nucleic acid double helix, an action that is critical to transcription and nucleotide excision repair (NER), as well as other cell... view more (2006-04-07)

Is DNA Repair a Substitute for Sex?
Birds and bees may do it, but the microscopic animals called bdelloid rotifers seem to get along just fine without sex, thank you. What's more, they have done so over millions of years of evolution, resulting in at least 370 species. These hardy creatures somehow escape the usual drawback of... view more (2008-04-03)

Enhanced DNA-repair mechanism can cause breast cancer
Although defects in the "breast cancer gene," BRCA1, have been known for years to increase the risk for breast cancer, exactly how it can lead to tumor growth has remained a mystery.   view more (2007-10-15)

DNA repair proteins monitored at double-strand break
Investigators at St. Jude Children's Research Hospital had a molecule's eye view of the human cell's DNA repair kit as it assembled on a double-strand break to link together the broken ends.   view more (2007-05-10)

Stressed cells spark DNA repair missteps and speed evolution
When Dr. Susan Rosenberg, professor of molecular and human genetics at Baylor College of Medicine, first published her finding that the mutation rate increased in bacteria stressed by starvation, sometimes resulting in a rare change that benefited the bacteria, it was controversial.   view more (2005-09-16)

UNC scientists discover cellular 'SOS' signal in response to UV skin damage
New research from the University of North Carolina at Chapel Hill School of Medicine has identified two proteins that may help protect against skin cancer.   view more (2007-03-19)

Yale study offers insight into possible cause of lymphoma
The immune system's powerful cellular mutation and repair processes appear to offer important clues as to how lymphatic cancer develops, Yale School of Medicine researchers report this week in Nature.   view more (2008-02-15)

DNA repair teams' motto: 'To protect and serve'
When you dial 911 you expect rescuers to pull up at your front door, unload and get busy-not park the truck down the street and eat donuts.   view more (2006-11-17)

New study shows how genetic repair mechanism helps seal DNA breaks
As the genetic material, DNA is surprisingly reactive and under continuous assault from environmental toxins and reactive cellular metabolites, so a means of repairing DNA damage is essential to maintaining the integrity of our genetic blueprint for future generations.   view more (2006-10-23)

Mayo Clinic collaboration discovers protein amplifies DNA injury signals
A Mayo Clinic-led research collaboration has discovered that the protein MDC1 amplifies weak DNA injury signals so genetic repair can begin.   view more (2006-01-20)

A tiny protein plays a big role in DNA repair
Two of DNA's worst enemies, ultraviolet light and chemical carcinogens, can wreak havoc on the molecule by mutating individual nucleotides or changing its physical structure.   view more (2006-05-09)

Assessment model gauges lung cancer risk based on medical history and genetics
Physicians have little to help them predict development of lung cancer in their patients-even a history of heavy smoking doesn't really help, since only a small fraction of lifetime smokers develops the cancer.   view more (2006-04-05)
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