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Enzyme alerts cell's powerful army to repair DNA damage
Scientists know that inside each cell, a little engine called RNA polymerase II does one essential job: It copies instructions from genes in the nucleus that get carried to production units in the rest of the cell to support our daily needs.   view more (2007-09-06)

A new way to look at lung cancer and tobacco carcinogens
Two types of cancer-causing agents in cigarettes-a nicotine-derived chemical and polycyclic aromatic hydrocarbons (PAHs) are the main culprits in lung cancer. Exposure to tobacco smoke - both mainstream and second-hand - is a leading cause of cancer death in the United States.   view more (2008-05-29)

Mechanism controlling DNA damage response has potential novel medical applications
Investigators at St. Jude Children's Research Hospital have discovered a previously unrecognized mechanism that controls a key protein linked to the cell's response to stress-a finding that holds promise for new ways to enhance cancer therapies or protect cells from dying after exposure to damaging chemicals or radiation.   view more (2005-10-07)

New research suggests a potentially damaging effect of extremely low frequency electromagnetic fields
The effect of extremely low frequency electromagnetic fields (ELF-EMF), such as those emitted around high-voltage transmission lines on human health, is controversial. Some studies suggest an association between exposure to ELF-EMF and incidence of leukaemia, although little direct evidence exists that exposure causes damage to biological... view more... (2002-07-16)

Normal chromosome ends elicit a limited DNA damage response
Researchers at the Salk Institute for Biological Studies discovered that cells co-opted the machinery that usually repairs broken strands of DNA to protect the integrity of chromosomes.   view more (2005-11-28)

Cigarette smoke alters DNA in sperm, genetic damage could pass to offspring
The science has long been clear that smoking causes cancer, but new research shows that children could inherit genetic damage from a father who smokes.   view more (2007-06-01)

DNA repair mechanisms are concentrated in the active parts of the genome
Less than 10% of the human genome contains coded information in the form of genes. The 30,000-40,000 genes in the genome are found grouped in discrete regions of the chromosomes. Chemical agents and radiation habitually cause a large variety of injuries to the DNA which interferes in many cell processes, like transcription and replication, and... view more... (2002-10-01)

Diabetes linked to male infertility; excess sugars in the body have direct effect on sperm quality
Diabetes in men has a direct effect on fertility, a scientist told the 24th annual conference of the European Society of Human Reproduction and Embryology today.   view more (2008-07-09)

Weizmann Institute scientists discover a molecular security mechanism for keeping mutations in check
Everyone knows mutations - genetic mistakes in DNA, the material of heredity - are bad: The more mutations in the cell's DNA, the higher the risk of cancer developing.   view more (2006-05-05)

Damage from oxygen may be one cause of Parkinson's disease
Research by neuroscientists at the University of Virginia Health System shows that oxygen free radicals are damaging proteins in mitochondria, the tiny cellular 'batteries' of brain cells.   view more (2006-05-17)

First research to show that diabetes damages DNA in men's sperm and may affect fertility
Scientists have found that sperm from diabetic men have greater levels of DNA damage than sperm from men who do not have the disease. They warn that such DNA damage might affect a man's fertility.   view more (2007-05-03)

Cancer stem cells linked to radiation resistance
Certain types of brain cancer cells, called cancer stem cells, help brain tumors to buffer themselves against radiation treatment by activating a "repair switch" that enables them to continue to grow unchecked.   view more (2006-10-19)

Scientists track impact of DNA damage in the developing brain
Switching off a key DNA repair system in the developing nervous system is linked to smaller brain size as well as problems in brain structures vital to movement, memory and emotion.   view more (2009-07-28)

New study finds how cells with damaged DNA alert the immune system
Research led by biologists at the University of California, Berkeley, has found that damage to a cell's DNA sets off a chain reaction that leads to the increased expression of a marker recognized by the body's immune system.   view more (2005-07-05)

Oncologists could gain therapeutic advantage by targeting telomere protein
Inactivating a protein called mammalian Rad9 could make cancer cells easier to kill with ionizing radiation, according to research at Washington University School of Medicine in St. Louis.   view more (2006-02-17)

Genetically engineered mice yield clues to 'knocking out' cancer
Deleting two genes in mice responsible for repairing DNA strands damaged by oxidation leads to several types of tumors, providing additional evidence that such stress contributes to the development of cancer.   view more (2009-07-02)

UC researchers find new ways to regulate genes, reduce heart damage
Researchers at the University of Cincinnati (UC) are looking for ways to reduce or prevent heart damage by starting where the problem often begins: in the genes.   view more (2008-06-23)

Lithium may help radiation target cancer, spare healthy tissue
Vanderbilt-Ingram Cancer Center investigators have uncovered a mechanism that helps explain how lithium, a drug widely used to treat bipolar mood disorder, also protects the brain from damage that occurs during radiation treatments.   view more (2009-05-05)

FSU chemists using light-activated molecules to kill cancer cells
A key challenge facing doctors as they treat patients suffering from cancer or other diseases resulting from genetic mutations is that the drugs at their disposal often don't discriminate between healthy cells and dangerous ones -- think of the brute-force approach of chemotherapy, for instance.   view more (2007-08-09)

Mayo Clinic collaboration discovers protein amplifies DNA injury signals
A Mayo Clinic-led research collaboration has discovered that the protein MDC1 amplifies weak DNA injury signals so genetic repair can begin.   view more (2006-01-20)
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