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Common Enzyme is a Key Player in DNA Repair
A quarter century after they discovered it, researchers have identified the job of one of the most common DNA-damage response proteins. view more (2006-01-12)
Growing evidence of marijuana smoke's potential dangers
In a finding that challenges the increasingly popular belief that smoking marijuana is less harmful to health than smoking tobacco, researchers in Canada are reporting that smoking marijuana, like smoking tobacco, has toxic effects on cells. view more (2009-08-06)
New study shows how genetic repair mechanism helps seal DNA breaks
As the genetic material, DNA is surprisingly reactive and under continuous assault from environmental toxins and reactive cellular metabolites, so a means of repairing DNA damage is essential to maintaining the integrity of our genetic blueprint for future generations. view more (2006-10-23)
Jefferson scientists discover a key protein regulator of inflammation and cell death
Reporting in the journal Nature, researchers led by Emad Alnemri, Ph.D., professor of Biochemistry and Molecular Biology in the Kimmel Cancer Center at Jefferson, discovered a key protein component involved in inflammation. view more (2009-01-23)
New pathway provides more clues about BRCA1 role in breast cancer
A breast cancer gene's newly discovered role in repairing damaged DNA may help explain why women who inherit a mutated copy of the gene are at increased risk for developing both breast and ovarian cancer. view more (2008-01-16)
Analysis reveals extent of DNA repair army
Cells have the remarkable ability to keep track of their genetic contents and -- when things go wrong " to step in and repair the damage before cancer or another life-threatening condition develops. view more (2007-05-25)
Study supports DNA repair-blocker research in cancer therapy
Scientists at Dana-Farber Cancer Institute have uncovered the mechanism behind a promising new approach to cancer treatment: damaging cancer cells' DNA with potent drugs while simultaneously preventing the cells from repairing themselves. view more (2009-08-18)
Aging stem cells in mice may hold answers to diseases of the aged, Stanford study finds
As stem cells in the blood grow older, genetic mutations accumulate that could be at the root of blood diseases that strike people as they age, according to work done in mice by researchers at the Stanford University School of Medicine. view more (2007-06-07)
Discovery may result in new test to determine predisposition to cancer
Researchers at UCLA's Jonsson Comprehensive Cancer Center have developed an assay that may be used to help identify new genes that can predict a predisposition to cancer. view more (2009-03-25)
Protein binds whenever it can
Dutch cancer researcher Joost Martens has discovered that the protein p300, which plays an important role in the correct transcription of DNA to RNA, can bind to DNA at several sites. The protein can also occupy a position in various complexes, each with its own protein composition. This knowledge is important for gaining a better understanding of... view more... (2003-06-24)
Cancer Research Could Lead To Improved Detection Methods
Research into the development of cancer at the University of Liverpool could lead to earlier and improved detection methods for the disease. view more (2005-04-14)
Trial success for diabetic nerve therapy
A potentially ground-breaking treatment for nerve damage caused by diabetes has shown promising results in preclinical and early patient trials. view more (2006-05-31)
'Cannabis alters human DNA' -- new study
A new study published by University of Leicester researchers has found "convincing evidence" that cannabis smoke damages DNA in ways that could potentially increase the risk of cancer development in humans. view more (2009-06-17)
A better way to copy DNA
Scientists have developed a new method for DNA amplification that could replace the polymerase chain reaction (PCR), a technique that is invaluable for both medical diagnostics and basic research but which is confined to the laboratory. In the August issue of EMBO reports, Huimin Kong and colleagues at New England Biolabs (Beverly, MA, USA)... view more... (2004-07-14)
Few clues about African ancestry to be found in mitochondrial DNA
Mitochondrial DNA may not hold the key to your origins after all. A study published today in the open access journal BMC Biology reveals that fewer than 10% of African American mitochondrial DNA sequences analysed can be matched to mitochondrial DNA from one single African ethnic group. view more (2006-10-12)
CSHL scientists discover how 'companion' cells to sperm protect them from genetic damage
In plant pollen grains, sperm cells, which carry the genetic material to be passed on to progeny, are cocooned within larger "companion" cells that are called pollen vegetative cells. These companions provide sperm with energy and nourishment, and push them towards their targets during fertilization. view more (2009-02-06)
Vitamin D protects cells from stress that can lead to cancer
By inducing a specific gene to increase expression of a key enzyme, vitamin D protects healthy prostate cells from the damage and injuries that can lead to cancer, University of Rochester Medical Center researchers report. view more (2008-05-14)
Novel connection found between biological clock and cancer
Dartmouth Medical School geneticists have discovered that DNA damage resets the cellular circadian clock, suggesting links among circadian timing, the cycle of cell division, and the propensity for cancer. view more (2006-06-30)
Landmark studies assess risk of exposure to elevated levels of EMS confirm clear toxicity threshold
New data from studies presented at the XVII International AIDS Conference in Mexico City have provided unprecedented insight into the toxicity of an impurity called ethyl methanesulfonate (EMS). The formation of the EMS impurity is a potential by-product of the manufacturing of mesylate salts, which are contained in over 40 drugs currently... view more... (2008-08-05)
Chromosome glue repairs damaged DNA
When a strand of DNA breaks in the body's cells, it normally does not take long until it has been repaired. Now researchers at the Swedish medical university Karolinska Institutet have discovered a new mechanism that helps to explain how the cell performs these repairs. The results are presented in Science. view more (2007-07-16)
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