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University of Minnesota researchers take new look at cellular suicide
Like a bodyguard turned traitor, a protein whose regular job is to help repair severed DNA molecules will, in some cases, join forces with another protein to do the opposite and chop the DNA to bits. view more (2006-07-07)
Study of huge numbers of genetic mutations point to oxidative stress as underlying cause
A study that tracked genetic mutations through the human equivalent of about 5,000 years has demonstrated for the first time that oxidative DNA damage is a primary cause of the process of mutation - the fuel for evolution but also a leading cause of aging, cancer and other diseases. view more (2009-09-08)
Proteins in urine predict brain damage in laboratory animals
The study dealt with the development and prevention of strokes in particular rats which had spontaneously developed extremely high blood pressure. Such a high blood pressure level leads within a few weeks to damage to the kidneys, heart and brain such that the rats die. The researchers found that brain damage in these rats is always preceded by... view more... (1999-06-21)
October 15, 2009 Loss of Tumor-Suppressor and DNA-Maintenance Proteins Causes Tissue Demise, Penn Study Finds
A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrupts tissue maintenance in mice. As a result, tissues deteriorate rapidly, which is generally fatal in these animals. In addition, the study provides... view more... (2009-10-16)
The good and bad side of anti-cancer compounds
Compounds known as "HDAC inhibitors" exhibit cancer-killing activities in cultured cells. While they are currently being tested as anti-cancer agents in clinical trials, just how they execute their effects is unclear. view more (2008-04-11)
Electronic structure of DNA revealed for 1st time by Hebrew University and collaborating researchers
Utilizing a technique that combines low temperature measurements and theoretical calculations, Hebrew University of Jerusalem scientists and others have revealed for the first time the electronic structure of single DNA molecules. view more (2008-02-29)
DNA repair teams' motto: 'To protect and serve'
When you dial 911 you expect rescuers to pull up at your front door, unload and get busy-not park the truck down the street and eat donuts. view more (2006-11-17)
Cancer-causing gut bacteria exposed
Normal gut bacteria are thought to be involved in colon cancer but the exact mechanisms have remained unknown. Now, scientists from the USA have discovered that a molecule produced by a common gut bacterium activates signalling pathways that are associated with cancer cells. view more (2008-09-22)
Clawed frog helps Fanconi anemia research make leaps
A large, clawed frog is helping Oregon Health & Science University researchers gather a princely sum of knowledge on Fanconi anemia, a rare, genetic, cancer-susceptibility syndrome. view more (2006-01-25)
Nanoscale microscope sheds first light on gene repair
Proteins called H2AX act as "first aid" to DNA, among other roles. For the first time, scientists using the world's most powerful light microscope (the only one of its kind in the Americas) have seen how H2AX is distributed in the cell nucleus: in clusters, directing the first aid/repair after DNA injuries to the region where it is... view more... (2006-11-14)
Upside-down world: DNA protecting protein helps cancer drug to kill cells
Some DNA repair enzymes can become double-edged swords - If they work too slowly, they can block necessary cell maintenance and contribute to cell death. view more (2009-04-28)
Researchers find how a common genetic mutation makes cancer radiation resistant
Many cancerous tumors possess a genetic mutation that disables a tumor suppressor called PTEN. Now researchers at Washington University School of Medicine in St. Louis have shown why inactivation of PTEN allows tumors to resist radiation therapy. view more (2009-06-10)
Dartmouth study finds that arsenic inhibits DNA repair
Dartmouth researchers, working with scientists at the University of Arizona and at the Department of Natural Resources in Sonora, Mexico, have published a study on the impact of arsenic exposure on DNA damage. view more (2006-05-30)
Scientists develop new treatment for hereditary breast cancer
Researchers at the University of Sheffield, funded by Yorkshire Cancer Research, have discovered a new way of treating and preventing hereditary breast cancer. The latest finding describes how the use of a chemical inhibitor can specifically kill tumour cells, which have a defect in the gene causing hereditary breast cancer. This new treatment... view more... (2005-04-11)
Enzyme crystal structure reveals 'unexpected' genome repair functions
The research looked at XPB helicase from an archaea, a single cell organism similar to bacteria. Helicases are enzymes that unwind or separate the strands of the nucleic acid double helix, an action that is critical to transcription and nucleotide excision repair (NER), as well as other cell processes. view more (2006-04-07)
Photonic crystal biosensors detect protein-DNA interactions
Scientists at the University of Illinois have developed a new class of disposable, microplate-based optical biosensors capable of detecting protein-DNA interactions. Based on the properties of photonic crystals, the biosensors are suitable for the rapid identification of inhibitors of protein-nucleic acid and protein-protein interactions. view more (2008-09-24)
EU research suggests that PCBs damage sperm - but finds no dramatic effect on male fertility
Research by an EU-supported international team of scientists has shown that polychlorinated biphenyls (PCBs)[1]-synthetic organic chemicals found widely in the environment and absorbed in the diet - may damage sperm. view more (2005-10-13)
Scripps research team unravels new cellular repair mechanism
The cell cycle, which allows cells to replicate their DNA and produce new cells, is controlled by a complex concert of enzymes and other components. In addition there are "checkpoint" mechanisms that can block continuation of the process if something goes amiss. view more (2008-08-07)
Dual enzymatic activity of RECQ1 explained by different quaternary structures
The transient opening of the DNA double helix is a fundamental step in several DNA metabolic processes. This reaction is driven by proteins called helicases, which make use of ATP as fuel to unwind the DNA duplex. view more (2007-01-16)
UBC scientists find new way to extract diluted and contaminated DNA
University of British Columbia researchers have developed a new way to extract DNA and RNA from small or heavily contaminated samples that could help forensic investigators and molecular biologists get to "the truth." view more (2009-08-11)
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