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Controversial findings help explain evolution of life
Chemists at Oregon State University have pioneered a controversial theory about how supposedly-stable DNA bases can be pushed into a "dark state" in which they are highly vulnerable to damage from ultraviolet radiation - an idea that has challenged some of the most basic concepts of modern biochemistry. view more (2006-04-07)
Stopgap DNA Repair Needs a Second Step
One can have a dream, two can make that dream so real, goes a popular song. Now a Weizmann Institute study has revealed that it takes two to perform an essential form of DNA repair. view more (2009-05-04)
Tumor mutations can predict chemo success
New work by MIT cancer biologists shows that the interplay between two key genes that are often defective in tumors determines how cancer cells respond to chemotherapy. view more (2009-08-07)
Born under the sun: UV light and the origin of life
Early evolution of life as we know it may have depended on DNA's ability to absorb UV light. This insight into the early moments of life on Earth comes from research published today in the journal BMC Evolutionary Biology. The research fills in one of the major gaps in our understanding about the origins of life: how single molecules were able to... view more... (2003-05-27)
Faulty cell cycle checkpoints linked to lung cancer risk in African-Americans
Faulty cell cycle "checkpoints" that fail to respond to DNA damage effectively may contribute to the high incidence of lung cancer in African-Americans. view more (2005-10-17)
Prevent prostate cancer with antioxidants? Gene pathway may reveal more clues
Scientists from Maryland and New Jersey have identified a molecular pathway in mice that makes prostate cells vulnerable to cancer-causing oxygen damage. The pathway, which is also involved in human prostate cancer, may help determine how and whether antioxidants, such as certain vitamins or their products that reverse the damage, can prevent... view more... (2005-09-16)
M.D. Anderson-led team reports possible key to autoimmune disease
A human peptide that acts as a natural antibiotic against invading microbes can also bind to the body's own DNA and trigger an immune response in the absence of an infection, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in an early online publication in Nature. view more (2007-09-17)
Cancer related gene p53 not regulated as indicated by previous tissue culture research
The cellular cascade of molecular signals that instructs cells with fatally damaged DNA to self-destruct pivots on the p53 tumor suppressor gene. view more (2005-06-28)
Antitumor agent under the microscope
Mechanical stabilization of DNA keeps tumor cells in check Cisplatin is one of the most widely employed cancer medications. As with many other chemotherapy agents, the mechanism by which it works has not been fully researched. Now, thanks to Munich physicists Hermann E. Gaub, Rupert Krautbauer, and Hauke Clausen-Schaumann, an important step toward... view more... (2000-10-30)
Protein's essential role in repairing damaged cells revealed
University of Michigan researchers have discovered that a key protein in cells plays a critical role in not one, but two processes affecting the development of cancer. view more (2009-01-07)
Newly found DNA catalysts cleave DNA with water molecule
Better tools for manipulating DNA in the laboratory may soon be possible with newly discovered deoxyribozymes (catalytic DNA) capable of cleaving single-stranded DNA, researchers at the University of Illinois say. view more (2009-08-17)
Enzyme necessary for DNA synthesis can also erase DNA
In this week's edition of Proceedings of the National Academy of Sciences, PNAS, Uppsala University scientists describe a new mechanism behind an important process that causes a rapid reduction of DNA in the chromosomes of bacteria. view more (2009-06-09)
DNA constraints control structure of attached macromolecules
A new method for manipulating macromolecules has been developed by researchers at the University of Illinois at Urbana-Champaign. The technique uses double-stranded DNA to direct the behavior of other molecules. view more (2005-06-29)
Have The Police Hijacked Our DNA? (p 927)
Creating a DNA database of all UK men to assist in criminal investigations may sound extreme; however this week's editorial proposes that there has been no more rational option to date in an attempt to use DNA profiling to assist in the identification of violent offenders in the UK, 80% of whom are men. The over-reliance by police and governments... view more... (2003-09-17)
Unlocking the key to human fertility
Scientists at Leeds and Bradford have discovered a unique 'DNA signature' in human sperm, which may act as a key that unlocks an egg's fertility and triggers new life. view more (2009-08-03)
Computer simulation shows buckyballs deform DNA
Soccer-ball-shaped "buckyballs" are the most famous players on the nanoscale field, presenting tantalizing prospects of revolutionizing medicine and the computer industry. view more (2005-12-06)
Rampant helper syndrome
The Archaea are single-celled organisms and a domain unto themselves, quite apart from the so called eukaryotes, being bacteria and higher organisms. view more (2009-07-06)
DNA: Bacteria's survival ration
The ubiquitous bacteria E. coli rank among nature's most successful species for lots of reasons, to which biologists at the University of Southern California have added another: in a pinch, E. coli can feast on the DNA of their dead competitors. view more (2006-05-30)
Timing of radiation treatments for colon cancer may need adjusting, Jefferson researchers say
Scientists have unexpectedly discovered that mice with the gene defect that causes colon cancer in humans can differ from normal mice in how they respond to radiation treatments. view more (2006-04-10)
Heme controls antioxidants and iron in ferritin
More than one million Americans have abnormal iron levels in their bodies. For example, iron excess can lead to a long list of health problems including diabetes, heart failure, liver cancer, arthritis and severe fatigue. view more (2005-10-11)
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