DNA repair Current Events | DNA repair News | 2
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BRIT1 allows DNA repair teams access to damaged sites
Like a mechanic popping the hood of a car to get at a faulty engine, a tumor-suppressing protein allows cellular repair mechanisms to pounce on damaged DNA by overcoming a barrier to DNA access. view more (2009-06-22)
Researchers find how a common genetic mutation makes cancer radiation resistant
Many cancerous tumors possess a genetic mutation that disables a tumor suppressor called PTEN. Now researchers at Washington University School of Medicine in St. Louis have shown why inactivation of PTEN allows tumors to resist radiation therapy. view more (2009-06-10)
Normal chromosome ends elicit a limited DNA damage response
Researchers at the Salk Institute for Biological Studies discovered that cells co-opted the machinery that usually repairs broken strands of DNA to protect the integrity of chromosomes. view more (2005-11-28)
Abnormal DNA repair genes may predict pancreatic cancer risk
Abnormalities in genes that repair mistakes in DNA replication may help identify people who are at high risk of developing pancreatic cancer, a research team from The University of Texas M. D. Anderson Cancer Center reports in the Jan. 15 issue of Clinical Cancer Research. view more (2009-01-16)
Chromatin remodeling complex connected to DNA damage control
When molecular disaster strikes, causing structural damage to DNA, players in two important pathways talk to each other to help contain the wreckage, scientists at The University of Texas M. D. Anderson Cancer Center report in the August edition of Cell. view more (2007-08-10)
Enzyme crystal structure reveals 'unexpected' genome repair functions
The research looked at XPB helicase from an archaea, a single cell organism similar to bacteria. Helicases are enzymes that unwind or separate the strands of the nucleic acid double helix, an action that is critical to transcription and nucleotide excision repair (NER), as well as other cell processes. view more (2006-04-07)
Stopgap DNA Repair Needs a Second Step
One can have a dream, two can make that dream so real, goes a popular song. Now a Weizmann Institute study has revealed that it takes two to perform an essential form of DNA repair. view more (2009-05-04)
Is DNA Repair a Substitute for Sex?
Birds and bees may do it, but the microscopic animals called bdelloid rotifers seem to get along just fine without sex, thank you. What's more, they have done so over millions of years of evolution, resulting in at least 370 species. These hardy creatures somehow escape the usual drawback of asexuality - extinction - and the MBL's David Mark... view more... (2008-04-03)
Enhanced DNA-repair mechanism can cause breast cancer
Although defects in the "breast cancer gene," BRCA1, have been known for years to increase the risk for breast cancer, exactly how it can lead to tumor growth has remained a mystery. view more (2007-10-15)
DNA repair proteins monitored at double-strand break
Investigators at St. Jude Children's Research Hospital had a molecule's eye view of the human cell's DNA repair kit as it assembled on a double-strand break to link together the broken ends. view more (2007-05-10)
Stressed cells spark DNA repair missteps and speed evolution
When Dr. Susan Rosenberg, professor of molecular and human genetics at Baylor College of Medicine, first published her finding that the mutation rate increased in bacteria stressed by starvation, sometimes resulting in a rare change that benefited the bacteria, it was controversial. view more (2005-09-16)
Genetically engineered mice yield clues to 'knocking out' cancer
Deleting two genes in mice responsible for repairing DNA strands damaged by oxidation leads to several types of tumors, providing additional evidence that such stress contributes to the development of cancer. view more (2009-07-02)
UNC scientists discover cellular 'SOS' signal in response to UV skin damage
New research from the University of North Carolina at Chapel Hill School of Medicine has identified two proteins that may help protect against skin cancer. view more (2007-03-19)
Yale study offers insight into possible cause of lymphoma
The immune system's powerful cellular mutation and repair processes appear to offer important clues as to how lymphatic cancer develops, Yale School of Medicine researchers report this week in Nature. view more (2008-02-15)
Rampant helper syndrome
The Archaea are single-celled organisms and a domain unto themselves, quite apart from the so called eukaryotes, being bacteria and higher organisms. view more (2009-07-06)
Glitches in DNA repair genes predict prognosis in pancreatic cancer
Variations in mismatch repair genes can help predict treatment response and prognosis in patients with pancreatic cancer, according to research from The University of Texas M. D. Anderson Cancer Center presented today in advance of the American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium. view more (2009-01-14)
DNA repair teams' motto: 'To protect and serve'
When you dial 911 you expect rescuers to pull up at your front door, unload and get busy-not park the truck down the street and eat donuts. view more (2006-11-17)
New study shows how genetic repair mechanism helps seal DNA breaks
As the genetic material, DNA is surprisingly reactive and under continuous assault from environmental toxins and reactive cellular metabolites, so a means of repairing DNA damage is essential to maintaining the integrity of our genetic blueprint for future generations. view more (2006-10-23)
Mayo Clinic collaboration discovers protein amplifies DNA injury signals
A Mayo Clinic-led research collaboration has discovered that the protein MDC1 amplifies weak DNA injury signals so genetic repair can begin. view more (2006-01-20)
A tiny protein plays a big role in DNA repair
Two of DNA's worst enemies, ultraviolet light and chemical carcinogens, can wreak havoc on the molecule by mutating individual nucleotides or changing its physical structure. view more (2006-05-09)
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