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Cornell researchers identify a weak link in cancer cell armor
The seeming invincibility of cancerous tumors may be crumbling, thanks to a promising new gene therapy that eliminates the ability of certain cells to repair themselves. view more (2009-11-13)
Less-invasive technique has improved outcomes of aortic aneurysm repair
A shift toward a less-invasive endovascular procedure as an alternative to conventional surgery has reduced the risk of death for patients undergoing repair of dangerous abdominal aortic aneurysms (AAAs), reports a study in the March Journal of Vascular Surgery. view more (2006-03-08)
Diabetes linked to male infertility; excess sugars in the body have direct effect on sperm quality
Diabetes in men has a direct effect on fertility, a scientist told the 24th annual conference of the European Society of Human Reproduction and Embryology today. view more (2008-07-09)
Photonic crystal biosensors detect protein-DNA interactions
Scientists at the University of Illinois have developed a new class of disposable, microplate-based optical biosensors capable of detecting protein-DNA interactions. Based on the properties of photonic crystals, the biosensors are suitable for the rapid identification of inhibitors of protein-nucleic acid and protein-protein interactions. view more (2008-09-24)
DNA editing tool flips its target
Imagine having to copy an entire book by hand without missing a comma. Our cells face a similar task every time they divide. They must duplicate both their DNA and a subtle pattern of punctuation-like modifications on the DNA known as methylation. view more (2008-09-04)
Change in gene may be underlying molecular defect in some colorectal cancers, study suggests
Inactivation of a DNA repair gene may be an early step in the development of sporadic colorectal tumors, and detection of the molecular basis for this inactivation may ultimately be useful in risk assessment for colorectal cancer. view more (2005-09-21)
October 15, 2009 Loss of Tumor-Suppressor and DNA-Maintenance Proteins Causes Tissue Demise, Penn Study Finds
A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrupts tissue maintenance in mice. As a result, tissues deteriorate rapidly, which is generally fatal in these animals. In addition, the study provides... view more... (2009-10-16)
When Good DNA Goes Bad: Backward DNA leads to DNA breaks associated with leukemia, study finds
When otherwise normal DNA adopts an unusual shape called Z-DNA, it can lead to the kind of genetic instability associated with cancers such as leukemia and lymphoma. view more (2006-02-13)
A cancer gene causing tumours by a 'double-whammy' mechanism also reveals the key to a cure
Scientists at the Babraham Institute have discovered that a tiny change in a protein involved in cell survival is responsible for abnormal cell activity in the early stages of cancer. The protein, known as Bcl-xL, normally protects cells from dying; and when the DNA in cells becomes damaged, Bcl-xL is modified so that it no longer keeps the cells... view more... (2004-01-21)
Scripps research team unravels new cellular repair mechanism
The cell cycle, which allows cells to replicate their DNA and produce new cells, is controlled by a complex concert of enzymes and other components. In addition there are "checkpoint" mechanisms that can block continuation of the process if something goes amiss. view more (2008-08-07)
Study links high levels of nitric oxide to infertility and sperm DNA damage
Iranian scientists have linked a chemical that plays an essential role in many bodily functions to sperm DNA damage and male infertility. view more (2006-06-19)
FSU chemists using light-activated molecules to kill cancer cells
A key challenge facing doctors as they treat patients suffering from cancer or other diseases resulting from genetic mutations is that the drugs at their disposal often don't discriminate between healthy cells and dangerous ones -- think of the brute-force approach of chemotherapy, for instance. view more (2007-08-09)
Small addition to cancer drug may make big difference
University of Florida researchers have found a way to use just a fraction of the normal dosage of a highly toxic, debilitating chemotherapy drug to achieve even better results against colon cancer cells. view more (2009-12-09)
Protein binds whenever it can
Dutch cancer researcher Joost Martens has discovered that the protein p300, which plays an important role in the correct transcription of DNA to RNA, can bind to DNA at several sites. The protein can also occupy a position in various complexes, each with its own protein composition. This knowledge is important for gaining a better understanding of... view more... (2003-06-24)
Australian study sheds light on kidney repair and disease
A study by Monash University researchers has shed new light on the microscopic antennas in the kidney that are involved in the organ's repair process. view more (2009-09-30)
Enhanced skin cancer risk linked to defects in cellular aging controls
Cell lifespan is limited by telomeres, DNA sequences that cap chromosomes and control the number of times a cell may be copied. A new study reported in Disease Models & Mechanisms (DMM), dmm.biologists.org, describes how telomere dysfunction in skin cells can lead to increased skin cancer risk and pigmentation. view more (2009-02-23)
Researchers aim to cut future need for liver transplants
University of Edinburgh scientists have identified primitive liver cells —possibly dormant from the earliest developmental stage of a human being — which have the potential to mature into different cells types and help repair a failing liver. view more (2006-07-07)
Light activated anticancer drug targeted to DNA using cisplatin like sub-units
One of the most effective chemotherapy drugs against cancer is cisplatin because it attaches to cancer DNA and disrupts repair. view more (2006-03-27)
A better way to copy DNA
Scientists have developed a new method for DNA amplification that could replace the polymerase chain reaction (PCR), a technique that is invaluable for both medical diagnostics and basic research but which is confined to the laboratory. In the August issue of EMBO reports, Huimin Kong and colleagues at New England Biolabs (Beverly, MA, USA)... view more... (2004-07-14)
Few clues about African ancestry to be found in mitochondrial DNA
Mitochondrial DNA may not hold the key to your origins after all. A study published today in the open access journal BMC Biology reveals that fewer than 10% of African American mitochondrial DNA sequences analysed can be matched to mitochondrial DNA from one single African ethnic group. view more (2006-10-12)
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