DNA repair Current Events | DNA repair News | 7
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October 15, 2009 Loss of Tumor-Suppressor and DNA-Maintenance Proteins Causes Tissue Demise, Penn Study Finds
A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrupts tissue maintenance in mice. As a result, tissues deteriorate rapidly, which is generally fatal in these animals. In addition, the study provides... view more... (2009-10-16)
When Good DNA Goes Bad: Backward DNA leads to DNA breaks associated with leukemia, study finds
When otherwise normal DNA adopts an unusual shape called Z-DNA, it can lead to the kind of genetic instability associated with cancers such as leukemia and lymphoma. view more (2006-02-13)
A cancer gene causing tumours by a 'double-whammy' mechanism also reveals the key to a cure
Scientists at the Babraham Institute have discovered that a tiny change in a protein involved in cell survival is responsible for abnormal cell activity in the early stages of cancer. The protein, known as Bcl-xL, normally protects cells from dying; and when the DNA in cells becomes damaged, Bcl-xL is modified so that it no longer keeps the cells... view more... (2004-01-21)
Scripps research team unravels new cellular repair mechanism
The cell cycle, which allows cells to replicate their DNA and produce new cells, is controlled by a complex concert of enzymes and other components. In addition there are "checkpoint" mechanisms that can block continuation of the process if something goes amiss. view more (2008-08-07)
Study links high levels of nitric oxide to infertility and sperm DNA damage
Iranian scientists have linked a chemical that plays an essential role in many bodily functions to sperm DNA damage and male infertility. view more (2006-06-19)
FSU chemists using light-activated molecules to kill cancer cells
A key challenge facing doctors as they treat patients suffering from cancer or other diseases resulting from genetic mutations is that the drugs at their disposal often don't discriminate between healthy cells and dangerous ones -- think of the brute-force approach of chemotherapy, for instance. view more (2007-08-09)
Australian study sheds light on kidney repair and disease
A study by Monash University researchers has shed new light on the microscopic antennas in the kidney that are involved in the organ's repair process. view more (2009-09-30)
Protein binds whenever it can
Dutch cancer researcher Joost Martens has discovered that the protein p300, which plays an important role in the correct transcription of DNA to RNA, can bind to DNA at several sites. The protein can also occupy a position in various complexes, each with its own protein composition. This knowledge is important for gaining a better understanding of... view more... (2003-06-24)
Researchers aim to cut future need for liver transplants
University of Edinburgh scientists have identified primitive liver cells —possibly dormant from the earliest developmental stage of a human being — which have the potential to mature into different cells types and help repair a failing liver. view more (2006-07-07)
Enhanced skin cancer risk linked to defects in cellular aging controls
Cell lifespan is limited by telomeres, DNA sequences that cap chromosomes and control the number of times a cell may be copied. A new study reported in Disease Models & Mechanisms (DMM), dmm.biologists.org, describes how telomere dysfunction in skin cells can lead to increased skin cancer risk and pigmentation. view more (2009-02-23)
Light activated anticancer drug targeted to DNA using cisplatin like sub-units
One of the most effective chemotherapy drugs against cancer is cisplatin because it attaches to cancer DNA and disrupts repair. view more (2006-03-27)
A better way to copy DNA
Scientists have developed a new method for DNA amplification that could replace the polymerase chain reaction (PCR), a technique that is invaluable for both medical diagnostics and basic research but which is confined to the laboratory. In the August issue of EMBO reports, Huimin Kong and colleagues at New England Biolabs (Beverly, MA, USA)... view more... (2004-07-14)
Few clues about African ancestry to be found in mitochondrial DNA
Mitochondrial DNA may not hold the key to your origins after all. A study published today in the open access journal BMC Biology reveals that fewer than 10% of African American mitochondrial DNA sequences analysed can be matched to mitochondrial DNA from one single African ethnic group. view more (2006-10-12)
University of Pittsburgh discovers genetic 'shut down' trigger in healthy immune cells
A fundamental genetic mechanism that shuts down an important gene in healthy immune system cells has been discovered that could one day lead to new therapies against infections, leukemia and other cancers. view more (2007-05-10)
CSHL-led team identifies key decision-point at which cells with broken DNA repair themselves or die
When cells undergo potentially catastrophic damage, for example as a result of exposure to ionizing radiation, they must make a decision: either to fix the damage or program themselves for death, a process called apoptosis. view more (2009-04-13)
Mount Sinai first in US to implant FDA-cleared ring for mitral valve repair
David H. Adams, MD, Marie-Josée and Henry R. Kravis Professor and Chairman of the Department of Cardiothoracic Surgery at The Mount Sinai Medical Center, performed the first two implantations of the Carpentier-Edwards Physio II ring in the United States yesterday. view more (2009-02-25)
Proof-Of-Principle Data For Nerve Repair Programme Presented At The 10th International Symposium On Neural Regeneration
Oxford BioMedica announced today that interim preclinical data from the InnurexTM nerve repair programme are being presented by Prof. Malcolm Maden of King's College London at the 10th International Symposium on Neural Regeneration which is being held at the Asilomar Conference Center, Pacific Grove, California. The data, which will shortly be... view more... (2003-12-15)
Finding a cure for cancer: the holy grail of science
To find a cure for cancer, the modern-day plague of our society - is synonymous to finding the holy grail of science. view more (2006-11-22)
Handle with care: Telomeres resemble DNA fragile sites
Telomeres, the repetitive sequences of DNA at the ends of linear chromosomes, have an important function: They protect vulnerable chromosome ends from molecular attack. view more (2009-07-10)
Protein plays unexpected role protecting chromosome tips
A protein specialist that opens the genomic door for DNA repair and gene expression also turns out to be a multi-tasking workhorse that protects the tips of chromosomes and dabbles in a protein-destruction complex, a team lead by researchers at The University of Texas M. D. Anderson Cancer Center reports in the Aug. 13 edition of Molecular Cell. view more (2009-08-14)
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