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Rac 1 and 2, two proteins essential to triggering of the immune response
The dendritic cells act as the body's sentries, standing guard around the clock. As soon as they detect a potential enemy, they alert the T cells, whose role is to defend the body. At the Institut Curie, CNRS researchers in an Inserm laboratory have filmed the encounter of dendritic cells and T cells. They have shown that this "rendez-vous",... view more... (2004-08-23)
Parasite lipids against asthma or diabetes
Dutch research has demonstrated that lipids from the parasite schistosoma can inhibit human immune responses. This property makes the lipids interesting for a possible new treatment of diseases such as asthma and diabetes where the immune system responds inappropriately. During her doctoral research, Desiree van der Kleij discovered that lipids... view more... (2003-11-11)
'Super' enzyme may lead way to better tumor vaccines
A "super" form of the enzyme Akt1 could provide the key to boosting the effect of tumor vaccines by extending the lives of dendritic cells, the immune-system master switches that promote the response of T-cells, which attack tumors, said researchers at Baylor College of Medicine in a report that appears in the "advance online... view more... (2006-12-04)
Better vaccines with special cells
More effective vaccines will be developed as a result of research at the University of Dundee which is harnessing the skills of special cells in the body`s immune response process. The Medical Research Council has awarded Professor Colin Watts and his colleagues £1.2 million to fund work on key cells in our immune system called dendritic... view more... (2002-02-25)
Malaria parasite impairs key immune system cells
Plasmodium, the parasite responsible for malaria, impairs the ability of key cells of the immune system to trigger an efficient immune response. view more (2006-04-12)
New origin found for a critical immune response
An immune system response that is critical to the first stages of fighting off viruses and harmful bacteria comes from an entirely different direction than most scientists had thought, according to a finding by researchers at the Duke University Medical Center. view more (2009-03-02)
A new step towards an AIDS vaccine
Progressive disease after HIV infection is inversely correlated with the presence of plasmacytoid dendritic cells (pDCs), a subset of the dendritic cell family and the major producers of type 1 interferon in the body. view more (2005-10-14)
Immune cells promote blood vessel formation in mouse endometriosis
A discovery in mice of immune cells that promote the formation of new blood vessels could lead to new treatments for endometriosis, a painful condition associated with infertility that affects up to 15 percent of women of reproductive age. view more (2007-10-19)
Antibiotics may not be enough to stop recurrent gastric lymphoma caused by Helicobacter pylori
Research led by Dr. Anne Mueller at Stanford University School of Medicine demonstrates that successful eradication of Helicobacter may not prevent future aggressive gastric lymphoma since resting B cells are left behind. view more (2005-08-25)
USC researchers discover novel way to develop tumor vaccines
Researchers at the University of Southern California (USC) have uncovered a new way to develop more effective tumor vaccines by turning off the suppression function of regulatory T cells. view more (2008-03-03)
Don't be a stranger to yourself
One of the most important tasks of the immune system is to identify what is foreign and what is self. If this distinction fails, then the body's own structures will be attacked, the result of which could be an autoimmune disease such as diabetes mellitus type 1 or multiple sclerosis. view more (2009-03-16)
Immune system pathway identified to fight allergens, asthma
For the first time, researchers from the University of Pittsburgh School of Medicine have identified genetic components of dendritic cells that are key to asthma and allergy-related immune response malfunction. view more (2008-05-08)
Novel method to create personalized immunotherapy treatments
Argos Therapeutics and Université de Montréal today announced the presentation of new information on Argos'process for developing dendritic cell-based immunotherapies for HIV. view more (2008-08-06)
T cells activated to fight HIV basis for dendritic cell therapeutic vaccine
Having their immune system cells go through a laboratory version of boot camp may help patients win their battle against HIV. view more (2006-08-14)
Vitamin A signals offer clues to treating autoimmunity
Distributed around the body, dendritic cells act as the security alarms of the immune system. After sensing the presence of intruders, dendritic cells can transmit the alarm to white blood cells or tell them to relax, depending on the signals they send out. view more (2009-03-02)
Personalized immunotherapy to fight HIV/AIDS
For a long time, the main obstacle to creating an AIDS vaccine has been the high genetic variability of the HIV virus. Dr. Jean-Pierre Routy and his team from the Research Institute of the McGill University Health Centre (MUHC), in collaboration with Dr. Rafick Sékaly from the Université de Montréal, have overcome this... view more... (2008-08-18)
New understanding of basic units of memory
A molecular "recycling plant" permits nerve cells in the brain to carry out two seemingly contradictory functions - changeable enough to record new experiences, yet permanent enough to maintain these memories over time. view more (2007-09-20)
Careless talk costs lives in food allergy
A team of scientists, led by the Institute of Food Research (IFR) in the UK, has discovered an immune system malfunction that is likely to play a profound role in food allergy. Food allergy can be life threatening, but understanding the cause has remained a challenge for science. The international team has found that two types of cells stop... view more... (2004-05-05)
Why doesn't the immune system attack the small intestine?
Answering one of the oldest questions in human physiology, researchers at Dana-Farber Cancer Institute have discovered why the body's immune system-perpetually on guard against foreign microbes like bacteria - doesn't attack tissues in the small intestine that harbor millions of bacteria cells. view more (2007-01-10)
New vaccine approach prevents/reverses diabetes in lab study at Children's Hospital of Pittsburgh
Microspheres carrying targeted nucleic acid molecules fabricated in the laboratory have been shown to prevent and even reverse new-onset cases of type 1 diabetes in animal models. The results of these studies were reported by diabetes researchers at the John G. Rangos Sr. Research Center at Children's Hospital of Pittsburgh of UPMC and Baxter... view more... (2008-05-29)
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