Dendritic Cells Current Events | Dendritic Cells News | 4
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Sounding the alarm for infections: EMBL researchers discover rapid-response, interferon-producing cells
Nearly fifty years ago, researchers discovered that when cells in laboratory cultures are infected by a virus, they secrete a substance that protects other cells from infection. In 1957 Alick Issaks and Jean-Jacques Lindenmann traced this effect to a protein called interferon, a molecule now known to play a key role in the immune system. Human and... view more... (2002-02-15)
Implants mimic infection to rally immune system against tumors
Bioengineers at Harvard University have shown that small plastic disks impregnated with tumor-specific antigens and implanted under the skin can reprogram the mammalian immune system to attack tumors. view more (2009-01-23)
The multi-tasking reovirus
In the past couple of years, researchers at Oncolytics Biotech have been developing a harmless virus as a potent cancer killer, but they have also been accumulating data that suggests in addition to directly killing tumor cells, the reovirus may prime the immune system to mount a separate, powerful and long lasting defence against cancer. view more (2007-02-08)
Meth Promotes Spread of Virus in HIV-Infected Users
Researchers at the University at Buffalo have presented the first evidence that the addictive drug methamphetamine, or meth, also commonly known as "speed" or "crystal," increases production of a docking protein that promotes the spread of the HIV-1 virus in infected users. view more (2006-08-07)
Pancreatic cancer vaccine halts progression of disease in some patients
A dendritic cell-based therapeutic vaccine for pancreatic cancer developed by researchers at the University of Pittsburgh School of Medicine has successfully stalled the disease from progressing in a handful of patients three years post-vaccination. view more (2007-04-18)
NIH scientists discover crucial control in long-lasting immunity
National Institutes of Health (NIH) scientists have identified a protein that plays matchmaker between two key types of white blood cells, T and B cells, enabling them to interact in a way that is crucial to establishing long-lasting immunity after an infection. view more (2008-10-13)
Mathematical models of adaptive immunity
More than five million people die every year from infectious diseases, despite the availability of numerous antibiotics and vaccines. view more (2008-12-12)
Lymph nodes harbor information on whether breast cancer will recur
Breast cancer often spreads through the lymph nodes in the arm pits (so-called axillary lymph nodes), and whether these lymph nodes are tumor-free or contain small metastases is an important factor in the decision of how aggressively to treat a patient. view more (2005-09-06)
A new view of drugs used to treat rheumatoid arthritis
Powerful drugs used to treat patients with rheumatoid arthritis have a profound, previously unrecognized effect on the immune system, breaking up molecular "training camps" for rogue cells that play an increasingly recognized role in autoimmune diseases like rheumatoid arthritis and lupus. view more (2008-01-21)
Development of DNA drugs gives hope to lupus patients
A generation of DNA-like compounds, class R inhibitory oligonucleotides (INH-ODNs), have been shown to effectively inhibit cells responsible for the chronic autoimmune condition lupus. view more (2009-05-28)
New target for HIV/AIDS drugs and vaccines discovered
Researchers from Rome, Italy, describe a finding in the August 2007 print issue of The FASEB Journal that could lead to new drugs to fight the HIV/AIDS virus, as well as new vaccines to prevent infection. view more (2007-07-27)
Novel vaccine shows promise against early-stage breast cancer
A diagnosis of breast cancer has taken on a new meaning in the past 10 years, as research has produced a host of new therapies and detection techniques, significantly improving long-term survival for women who have been fighting the disease. view more (2006-11-13)
New discoveries about neuron plasticity linked to learning and memory
Neurons experience large-scale changes across their dendrites during learning, say neuroscientists at The University of Texas at Austin in a new study that highlights the important role that these cell regions may play in the processes of learning and memory. view more (2005-11-02)
UCR researchers propose minocycline as a promising drug for patients with Fragile X syndrome
A UC Riverside-led team of biomedical scientists has found that a readily available drug called minocycline, used widely to treat acne and skin infections, can be used to treat Fragile X syndrome, the most common inherited cause of mental impairment and the most common cause of autism. view more (2008-10-03)
Traffic jam in brain causes schizophrenia symptoms
Schizophrenia waits silently until a seemingly normal child becomes a teenager or young adult. Then it swoops down and derails a young life. view more (2009-08-11)
New vaccine protects more effectively against tuberculosis
Globally, tuberculosis remains the number one killer in adults. Moreover, multi-drug-resistant tuberculosis strains are on the rise which cannot be treated by first-line drugs. view more (2005-08-29)
RNA-associated introns guide nerve-cell channel production
Researchers at the University of Pennsylvania School of Medicine have discovered that introns, or junk DNA to some, associated with RNA are an important molecular guide to making nerve-cell electrical channels. view more (2008-02-06)
Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies
Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM), a clinical stage biopharmaceutical company developing monoclonal antibodies for the treatment of cancer and serious virus infections, today reported that two preclinical studies presented during the AACR 100th Annual Meeting 2009 provided further confirmation of the immunomodulatory mechanisms... view more... (2009-04-22)
Cellular pathway yields potential new weapon in vaccine arsenal
When a cell has to destroy any of its organelles or protein aggregates, it envelopes them in a membrane, forming an autophagosome, and then moves them to another compartment, the lysosome, for digestion. Two years ago, Rockefeller University assistant professor Christian Münz showed that this process, called autophagy, sensitizes cells for... view more... (2006-12-27)
Communication within the immune system:Immune synapses cannot function without ZAP-70
A familial form of severe combined immune deficiency (SCID) is caused by anomalies of an enzyme called ZAP-70. If ZAP-70 is lacking or does not work, the T-cells, which play a key role in the mechanisms of immune defense, are no longer functional. Affected children therefore catch infections as soon as they are exposed to pathogenic... view more... (2002-10-24)
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