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New technique could dramatically lower costs of DNA sequencing
Using computer simulations, researchers at the University of Illinois have demonstrated a strategy for sequencing DNA by driving the molecule back and forth through a nanopore capacitor in a semiconductor chip. The technique could lead to a device that would read human genomes quickly and... view more (2007-12-13)

More 'functional' DNA in genome than previously thought
Surrounding the small islands of genes within the human genome is a vast sea of mysterious DNA. While most of this non-coding DNA is junk, some of it is used to help genes turn on and off.   view more (2007-12-12)

Protein splicing upsets the DNA colinearity paradigm
Understanding medical research problems often relies on the direct, linear relationship between the sequence of a protein and the DNA encoding that protein.   view more (2006-09-08)

DNA analysis reveals rapid population shift among Pleistocene cave bears
Studying DNA obtained from teeth of ancient cave bears, researchers have been able to identify a shift in a particular population of the bears inhabiting a European valley in the late Pleistocene era.   view more (2007-02-20)

International consortium announces the 1000 Genomes Project
An international research consortium today announced the 1000 Genomes Project, an ambitious effort to sequence the genomes of at least 1000 people to create the most detailed and medically useful catalogue to date of human genetic variation.   view more (2008-01-23)

Researchers Find Synthetic Molecules That May Literally Be The Key To “Locking Away” Unwanted DNA
Research chemists have a found a class of synthetic molecules that could quite literally act as a key which could lock away sections of DNA into a closely wound coil preventing proteins from interacting with particular sections of DNA code. By locking up the DNA in this way scientists could stop... view more (2002-04-15)

Epigenetic changes discovered in major psychosis
Scientists have discovered epigenetic changes (i.e. chemical changes to a gene that do not alter the DNA sequence) in individuals with schizophrenia and bipolar disorder. This is the first epigenome-wide investigation in psychiatric research, and this groundbreaking data may be a significant step... view more (2008-03-12)

Few clues about African ancestry to be found in mitochondrial DNA
Mitochondrial DNA may not hold the key to your origins after all. A study published today in the open access journal BMC Biology reveals that fewer than 10% of African American mitochondrial DNA sequences analysed can be matched to mitochondrial DNA from one single African ethnic group.   view more (2006-10-12)

Cracking the genetic code for control of gene expression
Molecular biologists, developmental biologists and computer scientists at the Universtity of Helsinki, Finland, came together to advance towards cracking the code for how gene expression is controlled.   view more (2006-01-13)

Rules to Target RNA Are Focus of Research
Once described as DNA's less-famous chemical cousin, RNA, or ribonucleic acid, recently has moved to center stage.   view more (2005-12-19)

DNA editing tool flips its target
Imagine having to copy an entire book by hand without missing a comma. Our cells face a similar task every time they divide. They must duplicate both their DNA and a subtle pattern of punctuation-like modifications on the DNA known as methylation.   view more (2008-09-04)

Scientists discover a genetic code for organizing DNA within the nucleus
DNA - the long, thin molecule that carries our hereditary material - is compressed around protein scaffolding in the cell nucleus into tiny spheres called nucleosomes.   view more (2006-07-20)

Single nucleotide polymorphisms and forensic genetics, maybe not such a perfect combination
Forensic genetics is the branch of genetics that, through DNA analysis and comparison, deals with the resolution of legal problems such as paternity tests. Recently, it has been proposed that single nucleotide polymorphisms (SNPs) could be used as a new genetic marker in the field eventually even... view more (2004-10-21)

Nuffield Council on Bioethics urges caution on patenting DNA
Patents involving DNA sequences should be the exception rather than the rule, according to a paper published today (23 July) by the Nuffield Council on Bioethics. The Discussion Paper, The ethics of patenting DNA, recommends a number of significant changes to the way that patents are granted... view more (2002-07-18)

Sequencing method yields fuller picture
University of Southern California biologists have developed a method for sequencing both chromosomes of an organism.   view more (2007-07-18)

Phoenix rising: Scientists resuscitate a 5 million-year-old retrovirus
A team of scientists has reconstructed the DNA sequence of a 5-million-year-old retrovirus and shown that it is able to produce infectious particles.   view more (2006-10-31)

One man's junk may be a genomic treasure
Scientists have only recently begun to speculate that what's referred to as "junk" DNA - the 96 percent of the human genome that doesn't encode for proteins and previously seemed to have no useful purpose - is present in the genome for an important reason.   view more (2007-07-13)

USC researchers explore genetic causes for male infertility
Researchers at the University of Southern California (USC) suggest epigenetics, or the way DNA is processed and expressed, may be the underlying cause for male infertility. The study will be published in the Dec. 12 issue of Public Library of Science One.   view more (2007-12-12)

Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration
Although repeating sequences of three nucleotides encoding some of the bodies' 20 amino acids are a normal part of protein composition, abnormal expansion of trinucleotide repeats is the known cause of multiple inherited neurodegenerative disorders, including Huntington disease.   view more (2007-11-14)

Scientists find clue to mechanisms of gene signaling and regulation
Scientists have discovered a pattern in the DNA sequence of the mouse genome that may play a fundamental part in the way DNA molecules regulate gene expression.   view more (2007-08-23)

Nanopore Method Could Revolutionize Genome Sequencing
A team led by physicists at the University of California, San Diego has shown the feasibility of a fast, inexpensive technique to sequence DNA as it passes through tiny pores. The advance brings personalized, genome-based medicine closer to reality.   view more (2006-04-07)

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription
The distribution of the four nucleotides along the DNA sequence encodes the genetic information in living systems. However, do nucleic acids possess other attributes that contribute to their biological functions?   view more (2007-03-14)

Public collections of DNA and RNA sequence reach 100 gigabases
The world's three leading public repositories for DNA and RNA sequence information have reached 100 gigabases [100,000,000,000 bases; the 'letters' of the genetic code] of sequence.   view more (2005-08-23)

Protein Sequences: Not So Predictable After All
Scientists have believed for decades that the sequencing of the human genome would automatically yield the sequences of proteins, the functional products of genes, and thus lead to the unraveling of the mechanisms behind human cell biology and disease. However, a paper published in Science today by... view more (2004-03-01)

New methods offer insight into regulatory DNA
Through the Human Genome Project, the HapMap Project and other efforts, we are beginning to identify genes that are modified in some diseases. More difficult to measure and identify are the regulatory regions in DNA - the 'managers' of genes - that control gene activity and might be important in... view more (2005-12-16)
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