Endothelial Current Events | Endothelial News | 5
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Therapeutic role found for carbon monoxide
In a medical case of Jekyll and Hyde, carbon monoxide - the highly toxic gas emitted from auto exhausts and faulty heating systems - has proven effective in treating the symptoms of pulmonary arterial hypertension (PAH), an extremely debilitating condition that typically leads to right heart failure and eventual death. view more (2006-09-19)
Study shows direct link between leptin and obesity-related cardiovascular disease
Obese people who don't have high cholesterol or diabetes might think they're healthy - despite the extra pounds. view more (2008-11-11)
Schepens scientists are first to discover angiogenesis switch inside blood vessel cells
Scientists at Schepens Eye Research Institute, an affiliate of Harvard Medical School, are the first to discover a switch inside blood vessel cells that controls angiogenesis (new blood vessel growth). view more (2006-05-19)
Model tissue system reveals cellular communication via amino acids
A team of researchers from the Massachusetts General Hospital Center for Engineering in Medicine (MGH-CEM) has found the first evidence of cell-to-cell communication by amino acids, the building blocks of proteins, rather than by known protein signaling agents such as growth factors or cytokines. view more (2009-04-06)
Pulmonary hypertension in children may result from reduced activity of gene regulator
Too little activity by gene regulators called PPARs appears to be a major player in the irreversible lung damage that can occur in children with heart defects, researchers say. view more (2009-03-06)
A new measure for the malignancy of melanoma
Every tumor, starting from a size of a few millimeters, depends on a supply of nutrients and oxygen. Therefore, using special growth factors, it induces vascular wall cells of neighboring blood vessels to sprout new capillaries in order to get connected to the blood circulation. view more (2009-03-12)
GEN reports on strategies to overcome blood-brain barrier
The blood-brain barrier (BBB) remains a major obstacle to the successful delivery of drugs to treat central nervous system (CNS) disorders, reports Genetic Engineering and Biotechnology News (GEN). view more (2009-02-06)
Study identifies another strategy for normalizing tumor blood supply
Manipulating levels of nitric oxide (NO), a gas involved in many biological processes, may improve the disorganized network of blood vessels supplying tumors, potentially improving the effectiveness of radiation and chemotherapy. view more (2008-02-21)
Biomarkers predict brain tumor's response to therapy
A report in Cancer Research, a journal of the American Association for Cancer Research, highlights a new biomarker that may be useful in identifying patients with recurrent glioblastoma, or brain tumors, who would respond better to anti-vascular endothelial growth factor therapy, specifically cediranib. view more (2009-06-24)
Nocturnal dialysis improves heart disease in patients with end-stage kidney failure
Night-time hemodialysis patients may have a greater capacity to repair their hearts and blood vessels compared to those on conventional dialysis three times a week. view more (2005-10-03)
Researchers discover 'sticky' proteins fuse adult stem cells to cardiac muscle, repairing hearts
Cardiologists are increasingly using adult stem cells in clinical trials to repair hearts following heart attacks, but no one has understood how the therapy actually works. view more (2007-02-16)
Researchers identify how binge drinking may drive heart disease
As the holidays arrive, a group of researchers has identified the precise mechanisms by which binge drinking contributes to clogs in arteries that lead to heart attack and stroke, according to a study published today in the journal Atherosclerosis. view more (2008-11-26)
Study reveals how blood flow force prevents clogged arteries
Machines on cell surfaces, mechanical and lifeless as bed springs, protect blood vessels by responding to blood flow force, according to research published today in the Journal of Cell Biology. view more (2008-08-26)
Farnesoid X receptor regulates cystathionase
The expression and activity of Cystathionase is reduced in rodent models of liver injury, leading to hyper-homocysteinemia and impaired generation of hydrogen sulphide, two factors that contribute to endothelial dysfunction and increased intrahepatic resistance. view more (2009-05-13)
Cancer drugs my build and not tear down blood vessels
Scientists have thought that one way to foil a tumor from generating blood vessels to feed its growth - a process called angiogenesis - was by creating drugs aimed at stopping a key vessel growth-promoting protein. But now the opposite seems to be true. view more (2008-11-10)
Ancient DNA helps UF researchers unearth potential hemophilia therapy
A cut can be life-threatening for people with hemophilia, whose bodies don't produce enough of a protein that prevents prolonged bleeding. view more (2006-02-28)
Protein controls blood vessel formation, offers new drug target
After an injury, the body grows new blood vessels to repair damaged tissue. But sometimes too much growth causes problems, as when new blood vessels in the eyes leak, causing diabetic retinopathy and blindness if not treated. view more (2007-12-05)
Study helps explain origins of cardiac fibrosis in patients with heart disease
A report led by researchers at Beth Israel Deaconess Medical Center (BIDMC) helps explain the origins of cardiac fibrosis, a stiffening of the heart muscle that leads to a variety of cardiac diseases, most notably heart failure. view more (2007-07-30)
A consistent decline in heart attack rates following the implementation of smoking bans
Strongly enforced legislation to restrict smoking produces rapid and substantial reductions in community rates of heart attack, according to a meta-analysis published today in Circulation, the journal of the American Heart Association. view more (2009-09-22)
Ambati study published in PNAS
The side effects of an experimental "gene-silencing" treatment that is currently being investigated for a variety of diseases are even more wide-ranging than previously discovered, according to a study by a University of Kentucky researcher. view more (2009-04-07)
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