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Building the blood-brain barrier
Construction of the brain's border fence is supervised by Wnt/b-catenin signaling, report Liebner et al. in The Journal of Cell Biology.    view more (2008-10-27)

UIC researchers make promising finding in severe lung disease
Researchers at the University of Illinois at Chicago have identified a novel function for an enzyme that plays a role in the tissue injury in acute respiratory distress syndrome, also known as ARDS.   view more (2008-06-30)

Molecule helps cells plug leaks following lung injury
Researchers at the University of Illinois at Chicago College of Medicine have identified a molecule that plays a critical role in the recovery of lung tissue following severe injury.   view more (2006-09-15)

Hemangioma arteriovenous malformations or how endothelial cells escape apoptosis (programmed cell death).
Hemangiomas included several types of vascular abnormalities. The first classification of vascular abnormalities was proposed in 1982. Since angiography is becoming a common investigation, a better identification of the vascular abnormalities was possible. Hemangiomas are frequent in children and... view more (1999-09-14)

ABC-transporters expressed on endothelial cell membranes efflux anti-HIV drugs
Researchers at Tulane University Medical Center in New Orleans (USA) have discovered that drug-efflux pumps, belonging to the ATP-binding cassette (ABC) transporter family, are constitutively expressed on vascular endothelial cells.   view more (2008-08-27)

Increased risk of coronary heart disease among UK Indian Asians may be genetic
The increased rates of premature coronary heart disease among UK Indian Asians may be due to genetic or other as yet undiscovered risk factors, rather than the usual suspects, suggests research in Heart.   view more (1999-04-26)

Study supports reason for concern in childhood and adolescent obesity
Study findings presented at the May 2008 Pediatric Academic Societies and Asian Society for Pediatric Research Joint Meeting indicate that childhood and adolescent obesity negatively impacts vascular endothelial function, which relates to cardiac health.   view more (2008-05-12)

ESC Congress 2004: Embryonic endothelial progenitor cells help overcome myocardial infarction in pigs
Myocardial infarction, caused by coronary artery occlusion, can lead up to loss of muscle tissue of the heart and functional detriment, even at times where rapid reperfusion strategies like PTCA or thrombolysis are at hand. In the study presented here, we investigated embryonic endothelial... view more (2004-08-30)

Healthy blood vessels may prevent fat growth
The cells lining blood vessels are known to be important for maintaining health, but researchers at the Indiana University School of Medicine believe these cells may perform an unsuspected task - controlling the development of fat cells.   view more (2008-09-22)

Use of statins shows improvement in erectile performance of some men
Researchers at the University of Pennsylvania School of Medicine say preliminary results of a small study show promise in improving erectile dysfunction (ED) in men who had shown minimal reaction to Viagra.   view more (2006-02-22)

Latex means environmentally friendly packaging
For several years, Caisa Andersoon has been trying to create a better barrier against moisture and oxygen in our food packaging. On December 20, she will submit her doctoral dissertation at Karlstad University in Sweden. Latex has long been used for various types of surface treatment of paper. In... view more (2002-12-17)

A Possible Mechanism For Pre-eclampsia? (p 1511)
Results of a preliminary study in this week's issue of THE LANCET suggest that there may be future tests to determine whether pregnant women are at risk of developing pre-eclampsia, a serious disorder of late pregnancy. Up to 8% of pregnant women develop pre-eclampsia (pregnancy-induced high blood... view more (2003-04-30)

Human vascular system in mice
The formation of new blood vessels, or angiogenesis, is an Achilles' heel of tumor growth, because tumors depend on the supply of oxygen and nutrients for survival.   view more (2008-04-15)

New Developments in Angiogenic Therapy Emerging from Oxford
Angiogenesis, the growth of new blood vessels, is important in the healthy body for healing wounds and, in females, for the monthly reproductive cycle and during pregnancy. It is controlled in the body through the use of the body’s own angiogenesis inhibitors and stimulators. In certain... view more (2002-08-23)

Potential diagnostic marker indicates effectiveness of anti-angiogenic drugs
If an anti-angiogenic drug is successfully starving a cancer patient's tumor to death, the number of endothelial cells circulating in the individual's bloodstream will decrease, thus providing a potential biomarker for gauging the medication's effectiveness.   view more (2006-09-18)

A novel mechanism of action for anti-tumor agent, CA4P
Anti-angiogenic agents have been successful in the clinic for blocking the growth of solid tumors. However, these agents used in combination with chemotherapy have improved the survival of patients with cancers by only several months.   view more (2005-10-07)

A stem cell type supposed to be crucial for angiogenesis and cancer growth does not exist?
Angiogenesis, the growth of new blood vessels, is a central process in diverse physiological and pathological situations such as healing of wounds and traumas, cardiovascular disorders, inflammatory conditions such as rheumatoid arthritis, and in cancer growth.   view more (2008-04-23)

Possible new compound for treatment of cerebral malaria
In a paper published online in PLoS Medicine researchers from Marseille describe the effects of a new compound that may be a future treatment for patients with cerebral malaria.   view more (2005-08-23)

Bio-engineering of blood vessels
Blood vessel prostheses work best when the biochemical and mechanical properties match reality as much as possible and when they are made of biodegradable material. To this end tissue technologists grow natural vascular wall cells, endothelial cells, in a biodegradable tube made of collagen.... view more (2002-04-16)

A few squares of dark chocolate a day may stave off artery hardening in smokers
Dark chocolate may stave off artery hardening in smokers, and a few squares every day could potentially cut the risk of serious heart disease.   view more (2005-12-20)

The benefits of green tea in reducing an important risk factor for heart disease
More evidence for the beneficial effect of green tea on risk factors for heart disease has emerged in a new study reported in the latest issue of European Journal of Cardiovascular Prevention and Rehabilitation.   view more (2008-07-02)

New study finds key role for VEGF in onset of sepsis
A study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) has found that the vascular endothelial growth factor (VEGF) protein is a key biomarker for sepsis, a severe inflammatory response that develops following a bacterial infection.   view more (2006-05-22)

Ultra-low-dose aspirin might decrease bleeding severity in portal hypertension
In rats with portal hypertension, ultra-low-dose aspirin has shown a normalizing effect of platelet-endothelial cell alterations and bleeding time. Further, this effect is mediated by Cyclooxygenase 2 inhibition.   view more (2007-10-10)

Slipping past the blood brain barrier: Research shows potential treatment for brain cancer
A compound that kills cancer can sneak past the blood brain barrier, which protects the brain from foreign substances, to do its work in fighting a particularly invasive brain cancer.   view more (2005-08-23)

How Bacteria get into Brains to Cause Meningitis
An international collaboration between medical researchers may have identified how meningitis causing bacteria cross from the blood into the brain, paving the way for new strategies to prevent this fatal disease, the Society for General Microbiology's Spring Meeting in Edinburgh heard today,... view more (2003-04-02)
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