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'Smart' mice teach scientists about learning process, brain disorders
Mice genetically engineered to lack a single enzyme in their brains are more adept at learning than their normal cousins, and are quicker to figure out that their environment has changed, a team led by researchers at UT Southwestern Medical Center has found. view more (2007-05-29)
Gene makes muscles in the obese store more fat
The gene encoding an enzyme that hinders muscle from burning fat manufactures three times more enzyme in the muscle of obese people than lean people. view more (2005-10-12)
Novel approach strips staph of virulence
An international team of researchers supported by the National Institutes of Health (NIH) has blocked staph infections in mice using a drug previously tested in clinical trials as a cholesterol-lowering agent. view more (2008-02-15)
Rare disease provides clues about enzyme role in arrhythmias
A University of Iowa study provides insight into a calcium-sensing enzyme already known to play a role in irregular heartbeats and other critical functions. view more (2008-12-12)
UCLA physicists report advance toward nanotechy approach to protein engineering
UCLA physicists report a significant step toward a new approach to protein engineering in the June 8 online edition, and in the July print issue, of the Journal of the American Chemical Society. view more (2006-06-12)
Scientists map steps to block key enzyme action in heart failure
Taking a cue from the way drugs like Viagra put the biological brakes on a key enzyme involved in heart failure, scientists at Johns Hopkins have mapped out a key chemical step involved in blocking the enzyme. view more (2008-11-12)
Stunning finding: Compounds protect against cerebral palsy
Two compounds developed by Northwestern University chemists have been shown to be effective in pre-clinical trials in protecting against cerebral palsy, a condition caused by neurodegeneration that affects body movement and muscle coordination. view more (2009-02-25)
Reversing effects of altered enzyme may fight brain tumor growth
An international team of scientists from the Moores Cancer Center at the University of California, San Diego, the University of North Carolina and several institutions in China have explained how a gene alteration can lead to the development of a type of brain cancer, and they have identified a compound that could staunch the cancer's growth. view more (2009-04-14)
Gene linked to rare disease activates fat breakdown
A gene earlier linked to a rare disease plays a critical role in the body's "finely tuned balance" of fat storage and break down, new evidence reported in the May Cell Metabolism reveals. view more (2006-05-10)
New telomere discovery could help explain why cancer cells never stop dividing
A group working at the Swiss Institute for Experimental Cancer Research (ISREC) in collaboration with the University of Pavia has discovered that telomeres, the repeated DNA-protein complexes at the end of chromosomes that progressively shorten every time a cell divides, also contain RNA. view more (2007-10-05)
Revealing the long-awaited atomic structure of a well-known enzyme
A Boston University-led research team has identified the structural underpinnings of a widely-known enzyme -- acetoacetate decarboxylase (AADase) -- that was first described correctly more than 43 years ago including how it accelerates its target reaction. view more (2009-05-21)
Knockout broccoli fights cancer
EATING your greens could be even better for you than anyone thought. Macerated raw broccoli turns out to contain small amounts of a potent chemical that inhibits the oxidising enzymes that damage DNA and potentially cause cancer. When you chew broccoli, its cells rupture, releasing an enzyme that produces a class of chemicals called... view more... (2003-04-05)
Promising target for new atherosclerosis therapies linked to leukemia
In recent years, scientists studying inflammation and atherosclerosis have seen their respective fields converging. Inflammation is an aspect of the immune response to injury and disease; atherosclerosis, with its characteristic lesions in the blood vessel walls, underlies most cardiovascular disease, including heart attacks and strokes. view more (2006-11-02)
Study shows enzyme builds neurotransmitters via newly discovered pathway
The new study describes a pathway-different than the one previously suggested-for the biosynthesis of neurotransmitter lipids, N-acyl ethanolamines (NAEs), which include the endogenous cannabinoid ("endocannabinoid") anandamide. view more (2006-09-12)
UCL study shows beans beat cancer
Scientists have discovered a new and potent anti-cancer compound in everyday food. The collaborative study led by UCL (University College London) shows that the compound-inositol pentakisphosphate-found in beans, nuts and cereals inhibits a key enzyme (phosphoinositide 3-kinase) involved in tumour growth. view more (2005-09-16)
Engineers build DNA 'nanotowers' with enzyme tools
Duke engineers have added a new construction tool to their bio-nanofabrication toolbox. Using an enzyme called TdTase, engineers can vertically extend short DNA chains attached to nanometer-sized gold plates. This advance adds new capability to the field of bio-nanomanufacturing. view more (2005-10-13)
Popping the cork on biofuel agriculture
Scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory have identified a novel enzyme responsible for the formation of suberin - the woody, waxy, cell-wall substance found in cork. view more (2009-10-20)
Enzyme action creates protein linked to Alzheimer's disease
Researchers at UT Southwestern Medical Center have defined a key step in the production of beta-amyloid, a short protein that is thought to be responsible for the development of Alzheimer's disease. view more (2005-08-15)
Computer-designed molecule to clean up fluorocarbons?
The chemical bond between carbon and fluorine is one of the strongest in nature, and has been both a blessing and a curse in the complex history of fluorocarbons. Now, in a powerful demonstration of the relatively new field of "computational chemistry". view more (2007-03-05)
New biomarker may predict leukemia aggressiveness
Scientists at the University of California, San Diego and the Moores UCSD Cancer Center have evidence of a potential new biomarker to predict the aggressiveness of an often difficult-to-treat form of leukemia. view more (2009-04-20)
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