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The structure of a key enzyme for infectious diseases solved at ESRF
A European team of scientists from the University of Dundee (UK), the Technical University of Munich (Germany) and the European Synchrotron Radiation Facility, ESRF, (France) have determined the structure of a key target enzyme for novel drug development to treat infectious diseases including malaria, tuberculosis and sexually transmitted... view more... (2003-08-12)
New theory from University of Leicester scientists underpins drug development and food processing
Scientists at the University of Leicester have shown that the textbook explanation of how enzymes work is wrong - at least for some enzymes. view more (2004-10-05)
Novel fungal enzyme reduces tumour progression
We need oxygen to survive, but ironically oxygen also speeds up aging and can cause cancer! Highly reactive forms of oxygen known as oxygen radicals are produced in our bodies, and this leads to tissue damage and disease. A paper in the June issue of Microbiology reports on a novel enzyme produced by a fungus that can mop up these rogue chemicals... view more... (2001-05-30)
New Piece Found in the Puzzle of Epigenetics
A team of scientists led by Professor Dirk Eick of Helmholtz Zentrum München has identified the enzyme TFIIH kinase as an important factor in the epigenetic regulation of the cell nucleus enzyme RNA polymerase II. view more (2009-06-17)
Body's anti-HIV drug explained
Humans have a built-in weapon against HIV, but until recently no one knew how to unlock its potential. view more (2008-10-13)
Affibody ligands to Finnzymes
Affibody AB and Finnzymes Oy today announce that they have established a collaboration. The scope of the collaboration is to develop Affibody® affinity ligands for use in amplification of genetic material. Under the agreement, Affibody will develop specific affinity ligands, Affibody® molecules, to be used in kits for HotStart polymerase... view more... (2004-03-24)
Penn researchers determine structure of smallpox virus protein bound to DNA
Researchers at the University of Pennsylvania School of Medicine have determined the structure of an important smallpox virus enzyme and how it binds to DNA. view more (2006-08-07)
Cellular self-eating promotes pancreatitis
To survive tough times, cells sometimes resort to a form of self-cannibalism called autophagy. But as Hashimoto et al. reveal, autophagy can have a down side, destroying the pancreas by prematurely activating a digestive enzyme. view more (2008-06-30)
Genetic Testing For Cell-Proliferation Enzyme Could Improve Treatment Of Acute Lymphoblastic Leukaemia (p 1033)
Authors of a Canadian research letter in this week's issue of THE LANCET describe how genetic testing for an enzyme involved in cancer-cell proliferation could identify patients at an increased risk of poor outcome from acute lymphoblastic leukaemia. The enzyme thymidylate synthase is associated with cell proliferation, and is therefore an... view more... (2002-03-20)
Neutrophils in rheumatoid arthritis: How to lessen inflammation but still fight infection
Neutrophils, which quickly congregate at the sites of infection and inflammation, are capable of ingesting microorganisms or other particles. view more (2006-06-16)
UT Southwestern: Killing bacteria isn't enough to restore immune function after infection
A bacterial molecule that initially signals to animals that they have been invaded must be wiped out by a special enzyme before an infected animal can regain full health, researchers at UT Southwestern Medical Center have found. view more (2008-09-11)
Hopkins researchers discover new link to schizophrenia
Neuroscientists at Johns Hopkins have discovered that mice lacking an enzyme that contributes to Alzheimer disease exhibit a number of schizophrenia-like behaviors. view more (2008-05-09)
Cow stomach holds key to turning corn into biofuel
An enzyme from a microbe that lives inside a cow's stomach is the key to turning corn plants into fuel, according to Michigan State University scientists. view more (2008-04-08)
Scientists Develop Method to Track Immune System Enzyme in Live Animals
Scientists supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) at the National Institutes of Health have created two mouse strains that will permit researchers to trace, in a live animal, the activity of an enzyme believed to play a crucial role both in the normal immune response as well as autoimmunity... view more... (2007-05-18)
New discovery: if it weren't for this enzyme, decomposing pesticide would take millennia
An enzyme inside a bacterium that grows in the soil of potato fields can - in a split second - break down residues of a common powerful pesticide used for killing worms on potatoes, researchers have found. view more (2005-10-25)
Developing enzymes to clean up pollution by explosives
Scientists at the University of York have uncovered the structure of an unusual enzyme which can be used to reverse the contamination of land by explosives. view more (2009-10-09)
Molecular partners required for appropriate neuronal gene repression
In their efforts to understand the complex biology of life, scientists often seek to isolate individual elements of the puzzle for study, to break the problem down to a more manageable size. Single genes and molecules are closely analyzed to better understand their specific interactions with other single entities within larger systems. view more (2005-08-04)
Mechanisms that prevent Alzheimer's Disease: Enzymatic activity plays key role
In a project involving the collaboration of several institutes, research scientists of the Johannes Gutenberg University Mainz have succeeded in gaining further insight in the functioning of endogenous mechanisms that protect against the development of Alzheimer's disease. view more (2009-02-24)
Typhoid carriers: a Salmonella gene mutation?
Salmonella enterica causes approximately 16 million cases of typhoid fever worldwide, killing around 500,000 per year. One in thirty of the survivors, however, become carriers, such as Typhoid Mary who caused several typhoid outbreaks in New York City at the beginning of the last century. In carriers the bacteria remain hidden inside cells and the... view more... (2002-06-25)
Gene test determines risk of heart surgery complications
Genetic differences can explain why some patients undergoing heart surgery later experience shock and kidney complications. view more (2009-05-01)
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