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Protein sensor for fatty acid buildup in mitochondria
Just as homes have smoke detectors, cells have an enzyme that responds to a buildup of fatty acids by triggering the production of a key molecule in the biochemical pathway that breaks down these fatty acids, according to investigators at St. Jude Children's Research Hospital. view more (2007-02-15)
Sleep Apnea Increases Heart Disease Risk
Obstructive sleep apnea, or periodic interruptions in breathing throughout the night, thickens sufferers' blood vessels. Moreover, it increases the risk of several forms of heart and vascular disease. view more (2009-05-05)
Structure of enzyme offers treatment clues for diabetes, Alzheimer's
Researchers from the University of Chicago and Argonne National Laboratory have deciphered the three-dimensional structure of insulin-degrading enzyme, a promising target for new drugs because it breaks down not only insulin but also the amyloid-beta protein, which has been linked to the cognitive decline of Alzheimer's disease. view more (2006-10-12)
Viagra®, unlikely tool for vision research, slows the visual response to flickering light
Therapeutic doses of Viagra® have been shown to influence the rate at which visual signals are integrated by the brain, affecting the way quick, repeated events, such as flickering light, are perceived. view more (2006-01-24)
MGH researchers describe new way to identify, evolve novel enzymes
The intricate interplay of proteins and other chemicals that underlies most biological activities requires the participation of enzymes, specialized molecules that accelerate chemical reactions between molecules. view more (2007-08-16)
'Super' enzyme may lead way to better tumor vaccines
A "super" form of the enzyme Akt1 could provide the key to boosting the effect of tumor vaccines by extending the lives of dendritic cells, the immune-system master switches that promote the response of T-cells, which attack tumors, said researchers at Baylor College of Medicine in a report that appears in the "advance online... view more... (2006-12-04)
Structure of cog at the hub of metabolism reveals anti-ageing function
The structure of a key energy-releasing enzyme found in all animals is designed to minimise free radical production, an international team of researchers report in the journal Science today. In a startling feat of structural biology, the team visualised the entire molecular structure of succinate dehydrogenase in the bacterium E. coli, allowing... view more... (2003-01-30)
Common Ancestry of Bacterium and Plants Could be Key to an Effective New Treatment for Chlamydia
Rutgers researchers have discovered that the Chlamydia bacterium, which causes a sexually transmitted disease (STD), shares an evolutionary heritage with plants. view more (2006-11-08)
Cholera pathogen reveals how bacteria generate energy to live
Researchers at Rensselaer Polytechnic Institute have discovered new details about how bacteria generate energy to live. In two recently published papers, the scientists add key specifics to the molecular mechanism behind the pathogen that causes cholera. view more (2007-01-30)
University of Minnesota research leads to new technology to protect human health
Larry Wackett and Michael Sadowsky, members of the University of Minnesota's BioTechnology Institute, developed an enzyme that is used in Bioo Scientific's new MaxDiscovery™ Melamine Test kit, which simplifies the detection of melamine contamination in food. view more (2009-07-22)
Cancer-causing protein may heal damaged spinal cord and brain cells
Cancer researchers at Columbia University Medical Center have found that a protein known for driving the growth of cancer also plays a surprising role in restoring the ability of neurons to regenerate, making it an important target for addressing spinal cord damage or neurological diseases like Alzheimer's. view more (2006-06-29)
University of Minnesota researchers take new look at cellular suicide
Like a bodyguard turned traitor, a protein whose regular job is to help repair severed DNA molecules will, in some cases, join forces with another protein to do the opposite and chop the DNA to bits. view more (2006-07-07)
ENZYME CONCENTRATIONS AND SKIN DISEASE MAY PREDICT SEVERITY OF REACTIONS TO BEE AND WASP STINGS (p 361)
Raised concentrations of the enzyme tryptase, associated with previously undiagnosed skin disease, may be a predictor of how people will react to bee and wasp stings, reports a study in this week’s issue of THE LANCET. 5% of adults in Europe and the USA have anaphylactic (hypersensitive) reactions to bee and wasp stings. The severity of... view more... (2001-01-31)
Researchers describe 'implausible' chemistry that produces herbicidal compound
A soil microbe that uses chemical warfare to fight off competitors employs an unusual chemical pathway in the manufacture of its arsenal, researchers report, making use of an enzyme that can do what no other enzyme is known to do: break a non-activated carbon-carbon bond in a single step. view more (2009-06-11)
Short sugar chains--a future drug for Alzheimer's?
Heparansulfate, which is needed for normal fetal development among other things, is also important for the build-up of amyloid, morbid protein deposits that appear in several serious diseases. This is shown by Uppsala scientists in an article published in today's Net edition of the U.S. journal Proceedings of the National Academy of Science.... view more... (2005-04-19)
Carb synthesis sheds light on promising tuberculosis drug target
A fundamental question about how sugar units are strung together into long carbohydrate chains has also pinpointed a promising way to target new medicines against tuberculosis. view more (2009-06-23)
Kamchatka Crabs Help Heal Burns
Recoverying from third and fourth degree burns, the most damaging types, is a slow and painful process that inevitably leaves excessive scar tissue. Russian researchers have developed a pharmacological enzyme preparation to accelerate the debridement process and wound healing, which reduces the preparation time for grafting and diminishes... view more... (2003-09-02)
Researchers find pathway and enzyme unique to tularemia organism
Researchers are closer to developing therapies to combat the deadly tularemia infection, according to a study published this week in the Proceedings of the National Academy of Sciences' online Early Edition. view more (2009-02-04)
Scientists discover that three molecules may be developed into new Alzheimer's drugs
A team of scientists has discovered three molecules -- from a search of 58,000 compounds -- that appear to inhibit a key perpetrator of Alzheimer's disease. view more (2005-07-25)
Scientists discover new chemical reaction for DNA production in bacteria and viruses
A team of researchers has discovered a new chemical reaction for producing one of the four nucleotides, or building blocks, needed to build DNA. view more (2009-04-17)
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