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3-D forms link antibiotic resistance and brain disease
The story of what makes certain types of bacteria resistant to a specific antibiotic has a sub-plot that gives insight into the cause of a rare form of brain degeneration among children, according to investigators at St. Jude Children's Research Hospital. view more (2006-08-21)
Researchers discover how acid reflux leads to esophageal cancer
A particular enzyme is significantly higher in cancer cells that have been exposed to acid, leading to the overproduction of hydrogen peroxide, and offering a possible explanation for how acid reflux may lead to cancer of the esophagus, according to a recent study in the Journal of Biological Chemistry. view more (2006-08-17)
Scientists reveal fine detail of cell`s energy machinery
A molecular pump that helps to keep cells flush with energy has been visualised by scientists at Imperial College, London. The structure of the pump, a key enzyme in bacterial respiration, reveals for the first time one of the molecular mechanisms that underpins cellular respiration, and confirms a Nobel Prize-winning theory proposed over 40... view more... (2002-03-05)
Naturally occurring enzyme can break down key part of Alzheimer's plaques
Scientists have identified a naturally occurring enzyme that can break down a key component of the brain plaques characteristic of Alzheimer's disease. view more (2006-10-25)
Animal research raises possibility of end to fat-free diets
A new study in mice raises a tantalizing possibility - that humans may one day be able to eat any kind of fat they want without raising their risk of heart disease. view more (2007-05-08)
The microbial hydrocarbon diet
Bioremediation of industrial sites and petrochemical spillages often involves finding microbes that can gorge themselves on the toxic chemicals. This leaves behind a non-toxic residue or mineralized material. view more (2009-06-12)
Fat cells send message that aids insulin secretion
The body's fat cells help the pancreas do its job of secreting insulin, according to research at Washington University School of Medicine in St. Louis. view more (2007-11-07)
Researchers reveal basis for debilitating hereditary disease
A research team led by scientists at The University of Texas Medical School at Houston has determined the structure of an enzyme that when defective causes an inherited disease that afflicts sufferers with severe abdominal pain, psychiatric symptoms, skin fragility, and light sensitivity. view more (2005-10-10)
Inhibition of iron-metabolizing enzyme reduces tumor growth
A report in the Journal of Biological Chemistry shows that inhibition of heme oxygenase-1, an enzyme involved in iron metabolism, reduces Kaposi sarcoma tumor growth. view more (2006-04-21)
Upside-down world: DNA protecting protein helps cancer drug to kill cells
Some DNA repair enzymes can become double-edged swords - If they work too slowly, they can block necessary cell maintenance and contribute to cell death. view more (2009-04-28)
Why does an anti-anthrax drug kill plants too?
Scientists at the John Innes Centre (JIC), Norwich (1) have today reported that a very successful antibiotic, which is harmless to humans but lethal to most bacteria, also kills plants. They have found that an enzyme, which is an important target for several families of antibiotics and was thought to exist only in bacteria, is also present in... view more... (2004-05-12)
UCSD researchers discover variants of natural tumor suppressor
Building on their 2005 discovery of an enzyme that is a natural tumor suppressor, researchers at the University of California, San Diego (UCSD) School of Medicine have now identified two variants of that enzyme which could provide new targets for therapies to treat diabetes, heart and neurological disease. view more (2007-04-10)
A new control mechanism for genetic code translation discovered in bacteria
Almost all organisms, from bacteria to human beings, share the same genetic code, a group of universal instructions used to convert DNA or RNA sequences into proteins, the "building blocks" of life. view more (2008-02-15)
Plague agent helps UT Southwestern researchers find novel signaling system in cells
The bacterium that causes bubonic plague would seem unlikely to help medical scientists, but researchers at UT Southwestern Medical Center have harnessed it to uncover a new regulatory mechanism that inhibits the immune system. view more (2006-05-26)
MSU 'green chemistry' could ease manufacture, boost usefulness of cancer drug
Research by Michigan State University chemist Kevin Walker is paving the way for potentially cleaner, more efficient production of cancer-fighting paclitaxel - better known as the blockbuster drug Taxol. view more (2009-04-03)
Enzyme inhibitor takes an unexpected approach toward blocking cancer-promoting protein
Scientists at Fox Chase Cancer Center have discovered a unique method of attack that may be used to inhibit signaling enzymes called kinases, which often have a role in sustaining drug-resistant cancerous cells. They have confirmed that IPA-3, a small molecular inhibitor of a kinase called PAK1, targets the enzyme's regulatory domain, mimicking... view more... (2009-09-08)
New clues to stroke role in Alzheimer's
Researchers have discovered key details of how stroke or traumatic brain injury can trigger Alzheimer's disease (AD) by enhancing formation of brain-clogging amyloid plaques. view more (2007-06-07)
Lack of key enzyme associated with development of rare tumor
Researchers at the National Institutes of Health have discovered that a rare tumor of the adrenal glands appears to result from a genetic deficiency of an important enzyme. The enzyme is one of a class of enzymes involved in halting a cell's response to hormones and appears to stop cells from dividing. view more (2006-06-12)
Enzyme inhibitors block replication Of SARS virus
Researchers have known since 2003 that a site on the virus is responsible for mediating proteases that allow the virus to replicate. Since then researchers have been testing protease inhibitors to lock up this site, known as SARS 3CLpro, and effectively stop the virus from infecting additional cells in the body. view more (2006-03-28)
Finding protection from tumor growth in unexpected places
Researchers have discovered that an enzyme commonly involved in regulating blood pressure also provides protection from tumor growth when strongly expressed in immune cells. view more (2007-06-06)
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