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'Birth control' for centrioles
Like DNA, centrioles need to duplicate only once per cell cycle. Rogers et al. uncover a long-sought mechanism that limits centriole copying, showing that it depends on the timely demolition of a protein that spurs the organelles' replication. view more (2009-01-26)
Phytochemicals may protect cartilage, prevent pain in joints
Johns Hopkins researchers have discovered that plant-derived compounds known for their ability to protect tissue also appear to block the activity of an enzyme that triggers inflammation in joints. view more (2005-10-04)
Scientists reveal DNA-enzyme interaction with first ever real time footage
For the first time scientists have been able to film, in real-time, the nanoscale interaction of an enzyme and a DNA strand from an attacking virus. view more (2007-09-18)
Conaway Lab uncovers function of potential cancer-causing gene product
The Stowers Institute's Conaway Lab has uncovered a previously unknown function of a gene product called Amplified in Liver Cancer 1 (Alc1), which may play a role in the onset of cancer. view more (2009-08-10)
Carnegie Mellon researchers to develop new drug delivery system
Carnegie Mellon University's Stefan F. Zappe is using adult neural stem cells to develop a new stem cell-based drug delivery therapy that may ultimately help treat a variety of inherited genetic disorders like Hunter syndrome. view more (2007-11-05)
Enzyme shreds Alzheimer's protein
An enzyme found naturally in the brain snips apart the protein that forms the sludge called amyloid plaque that is one of the hallmarks of Alzheimer's disease (AD), researchers have found. view more (2006-09-21)
Refusal of suicide order: Why tumor cells become resistant
Cells with irreparable DNA damage normally induce programmed cell death, or apoptosis. However, this mechanism often fails in tumor cells so that transformed cells are able to multiply and spread throughout the body. view more (2008-06-24)
Accelerated evolution converts RNA enzyme to DNA enzyme in vitro
This 'evolutionary conversion' provides a modern-day snapshot of how life as we understand it may have first evolved out of the earliest primordial mix of RNA-like molecules-sometimes referred to as the "pre-RNA world"-into a more complex form of RNA-based life (or the "RNA world") and eventually to cellular life based on DNA... view more... (2006-03-28)
Researchers probe enzyme that may lead to new SARS drugs
Researchers at the University of Illinois at Chicago and two other institutions have unraveled the structure of an important new drug target from the virus that causes SARS, severe acute respiratory syndrome. view more (2006-04-05)
New information points to safer methadone use for treatment of pain and addiction
New findings may significantly improve the safety of methadone, a drug widely used to treat cancer pain and addiction to heroin and other opioid drugs, according to researchers at Washington University School of Medicine in St. Louis and the University of Washington in Seattle. view more (2009-03-03)
Mutant rats resist warfarin
A new series of mutations have been discovered that allow rats to resist the effects of the popular poison warfarin. Research published in the open access journal BMC Genetics describes eighteen new genetic changes found in rats from four continents. view more (2009-02-06)
The link between fasting and acute attacks of porphyria
A team of researchers has discovered a molecular missing link that helps explain why fasting brings on acute attacks of the genetic disease hepatic porphyria. view more (2005-08-26)
Mayo Clinic researchers find agents that speed up destruction of proteins linked to Alzheimer's
Taking a new approach to the treatment and prevention of Alzheimer's disease, a research team led by investigators at the Mayo Clinic campus in Florida has shown that druglike compounds can speed up destruction of the amyloid beta (A-beta) proteins that form plaque in the brains of patients with the disorder. view more (2009-04-22)
Virus product could kill anthrax and beat antibiotic resistance
Researchers from Rockefeller University, New York, have developed a new way of killing dangerous bacteria like the ones which cause anthrax and pneumonia, using products from a virus, according to new research presented today (Tuesday, 07 September 2004) at the Society for General Microbiology's 155th Meeting at Trinity College Dublin. view more (2004-08-23)
WA discovery a key to blood cell development
A West Australian research team has made the world-first discovery a 'pied piper' molecule within blood cells, called Liar, that leads other molecules into the nucleus of the cell, and could offer a key in treating prostate, breast and colon cancers as well as leukemia. view more (2009-04-29)
Important factors involved in the synthesis of starch in plants
The classic model for explaining the biosynthesis of starch in plant leaves has been seriously called in to question. view more (2005-10-24)
Scripps scientists develop first examples of RNA that replicates itself indefinitely
Findings could inform biochemical questions about how life began. Now, a pair of Scripps Research Institute scientists has taken a significant step toward answering that question. The scientists have synthesized for the first time RNA enzymes that can replicate themselves without the help of any proteins or other cellular components, and the... view more... (2009-01-12)
First structure of transporter enzyme family is solved - Finding will aid drug design to combat depression, stroke and diabetes
Scientists are a step closer to understanding how essential nutrients, vitamins and minerals are ferried into cells. For the first time, a member of the Major Facilitator Superfamily (MFS) of transport proteins, found in almost every form of life, has been visualised by researchers from Imperial College London and the University of California, Los... view more... (2003-07-30)
Caught in the act: The dynamic dance of enzymes
In a new study in Nature, Brandeis University Howard Hughes Medical Investigator Dr. Dorothee Kern and collaborators pull back the curtain on the secret lives of enzymes, the ubiquitous proteins that catalyze chemical reactions in the cell. view more (2007-12-12)
Shining sweetness â€" fluorescent sugars shed new light on future TB therapies
The discovery that fluorescent sugar molecules mark important enzymes of the tuberculosis bacillus will facilitate investigation of the potential importance of the enzymes for future tuberculosis (TB) therapies. This insight is a gratifying "by-product" of research at the Institute of Organic Chemistry at the Graz University of... view more... (2003-05-19)
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