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Molds for Molecules
Molecular imprints in polymers as reaction vessels for pharmaceuticals research Materials with the tiniest of cavities, which can take up other molecules as "guests", play a meaningful role in science and technology. A particularly interesting process for the synthesis of materials with precisely... view more (2002-11-28)

New inhibitor has potential as cancer drug
Laboratory experiments have previously shown that cancer cells overproduce an enzyme, heparanase, which splits the body's own polysaccharide heparan sulfate into shorter fragments.   view more (2007-10-23)

Aspirin Does Not Reduce Effectiveness Of ACE Inhibitors
A systematic review in this week's issue of THE LANCET provides clarification for the debate about the use of angiotensin-converting-enzyme (ACE) inhibitors in combination with aspirin for the treatment of cardiovascular disease-combination therapy does not reduce the effect of ACE inhibition.... view more (2002-10-02)

Downstate researchers target multiple sclerosis
Researchers at SUNY Downstate Medical Center have developed a substance that inhibits the progress of multiple sclerosis (MS) in an animal model. The agent, a novel calpain inhibitor, can be administered orally.   view more (2006-11-22)

Enzyme inhibitor may provide strategy to treat some GI disorders, Jefferson researchers find
Drugs that block the activity of an enzyme might hold a key to treating chronic and severe disorders such as certain forms of constipation, hemorrhoids, anal fissures, Hirschsprung's disease and other similar gastrointestinal problems.   view more (2006-07-19)

Scientists stop autoimmune disease without shutting off immune system
Skin is our first line of defense against infection. But people with a rare, life-threatening autoimmune disease called pemphigus vulgaris lack that protection because their immune system attacks the proteins that hold skin cells together.   view more (2006-08-23)

UAB research could improve the prognosis and treatment of lung cancer
A group of scientists led by Professor Xavier Parés of the Department of Biochemistry and Molecular Biology at Universitat Autònoma de Barcelona, has published a research on AKR1B10, an enzyme that is detected in large quantities only in lung cancers, particularly those caused by... view more (2008-01-08)

U of I scientist develops enzyme inhibitor that may slow cancer growth
University of Illinois scientist Tim Garrow, in collaboration with Jiri Jiracek of the Czech Academy of Sciences, has applied for a provisional patent on a class of chemicals that has future therapeutic uses in medicine, specifically cancer treatment.   view more (2006-07-07)

Inhibition of iron-metabolizing enzyme reduces tumor growth
A report in the Journal of Biological Chemistry shows that inhibition of heme oxygenase-1, an enzyme involved in iron metabolism, reduces Kaposi sarcoma tumor growth.   view more (2006-04-21)

Alzheimer's drug based on Purdue-designed inhibitor begins clinical trials
A drug based on the design of a Purdue University researcher to treat Alzheimer's disease began the first phase of human clinical trials this week.   view more (2007-06-25)

p53, tumor suppression and aging
In the January 1 issue of Genes & Development, Dr. Mary Ellen Perry and colleagues validate the p53 inhibitor, Mdm2, as a promising target for cancer therapies.   view more (2006-01-03)

Defeating the 'superpests'
Scientists have developed a new technique that makes pesticides more effective by removing insects' ability to exhibit resistance.   view more (2005-10-10)

Insulin Pills
The issue of insulin-dependent diabetes has long been discussed. No wonder, as the problem concerns more than 5% of the world population. However, despite the enormous efforts and funds spent on its solution, the scientists so far have failed to replace the injections with pills. The difficulty is... view more (2002-02-26)

UCL study shows beans beat cancer
Scientists have discovered a new and potent anti-cancer compound in everyday food. The collaborative study led by UCL (University College London) shows that the compound-inositol pentakisphosphate-found in beans, nuts and cereals inhibits a key enzyme (phosphoinositide 3-kinase) involved in tumour... view more (2005-09-16)

New Weapon for Fighting Antibiotic Drug Resistance
The most important antibiotics in general use today are the b-lactam family of products, but the medical community faces a serious problem with these antibiotics: the increasing development of drug resistance. The resistance is caused by hydrolysis of the b-lactam by a bacterial lactamase enzyme,... view more (2003-08-11)

Blood pressure drugs associated with reduced risk of esophageal, pancreatic and colon cancers
Thousands of individuals currently taking angiotension converting enzyme (ACE) inhibitors, a type of medication commonly used to lower blood pressure, may be doing more than treating their hypertension.   view more (2006-05-24)

Research could lead to treatment for Alzheimer's disease
A molecule designed by a Purdue University researcher could lead to the first drug treatment for Alzheimer's disease.   view more (2007-04-19)

Flesh-eating bacteria escape body's safety net
Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered that so-called flesh-eating "Strep" bacteria use a specific enzyme to break free of the body's immune system, a finding which could potentially lead to new treatments for serious infections in... view more (2006-02-21)

Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
UCLA scientists, along with collaborators from Purdue University, have demonstrated that HIV protease inhibitors - crucial drugs for HIV treatment - block a cellular enzyme important for generating the structural scaffolding for the cell nucleus.   view more (2007-07-17)

Enzyme inhibitors block replication Of SARS virus
Researchers have known since 2003 that a site on the virus is responsible for mediating proteases that allow the virus to replicate. Since then researchers have been testing protease inhibitors to lock up this site, known as SARS 3CLpro, and effectively stop the virus from infecting additional... view more (2006-03-28)

Study provides clues to prevent spread of ovarian cancer
A drug that blocks production of an enzyme that enables ovarian cancer to gain a foothold in a new site can slow the spread of the disease and prolong survival in mice, according to a study by researchers from the University of Chicago Medical Center, but only if the drug is given early in the... view more (2008-03-14)

Scientists design potent anthrax toxin inhibitor
Scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), have engineered a powerful inhibitor of anthrax toxin that worked well in small-scale animal tests.   view more (2006-04-25)

Anthrax inhibitor counteracts toxin, may lead to new therapeutics
Researchers from Rensselaer Polytechnic Institute and the University of Toronto have designed a nanoscale assembly of molecules that successfully counteracts and inhibits anthrax toxin in animal and laboratory experiments.   view more (2006-04-24)

Sugar-coated antibiotics
Researchers from the John Innes Centre and the University of East Anglia have recently elucidated the structure and function of an enzyme which is involved in decorating antibiotics with sugar molecules.   view more (2008-05-29)

COX-2 inhibitor could be safest anti-inflammatory drug for older people (p 1751)
A Canadian study involving over 130,000 older people in this week's issue of THE LANCET shows how the anti-inflammatory cyclo-oxygenase-2 (COX-2) inhibitor celecoxib may have a lower risk of congestive heart failure compared with other non-steroidal anti-inflammatory drugs. Non-selective,... view more (2004-05-26)
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