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Molds for Molecules
Molecular imprints in polymers as reaction vessels for pharmaceuticals research Materials with the tiniest of cavities, which can take up other molecules as "guests", play a meaningful role in science and technology. A particularly interesting process for the synthesis of materials with precisely fitted cavities is known as molecular imprinting.... view more... (2002-11-28)
New inhibitor has potential as cancer drug
Laboratory experiments have previously shown that cancer cells overproduce an enzyme, heparanase, which splits the body's own polysaccharide heparan sulfate into shorter fragments. view more (2007-10-23)
Aspirin Does Not Reduce Effectiveness Of ACE Inhibitors
A systematic review in this week's issue of THE LANCET provides clarification for the debate about the use of angiotensin-converting-enzyme (ACE) inhibitors in combination with aspirin for the treatment of cardiovascular disease-combination therapy does not reduce the effect of ACE inhibition. Previous research has suggested that ACE inhibitors... view more... (2002-10-02)
Pancreatic cancer: Researchers find drug that reverses resistance to chemotherapy
For the first time researchers have shown that by inhibiting the action of an enzyme called TAK-1, it is possible to make pancreatic cancer cells sensitive to chemotherapy, opening the way for the development of a new drug to treat the disease. view more (2009-09-24)
Downstate researchers target multiple sclerosis
Researchers at SUNY Downstate Medical Center have developed a substance that inhibits the progress of multiple sclerosis (MS) in an animal model. The agent, a novel calpain inhibitor, can be administered orally. view more (2006-11-22)
Researchers Discover New Enzyme in Cancer Growth
While studying the mechanics of blood clots, researchers at the University of Oklahoma Health Sciences Center discovered a new enzyme that not only affects the blood, but seems to play a primary role in how cancer tumors expand and spread throughout the body. view more (2008-12-04)
Enzyme inhibitor may provide strategy to treat some GI disorders, Jefferson researchers find
Drugs that block the activity of an enzyme might hold a key to treating chronic and severe disorders such as certain forms of constipation, hemorrhoids, anal fissures, Hirschsprung's disease and other similar gastrointestinal problems. view more (2006-07-19)
Scientists stop autoimmune disease without shutting off immune system
Skin is our first line of defense against infection. But people with a rare, life-threatening autoimmune disease called pemphigus vulgaris lack that protection because their immune system attacks the proteins that hold skin cells together. view more (2006-08-23)
UAB research could improve the prognosis and treatment of lung cancer
A group of scientists led by Professor Xavier Parés of the Department of Biochemistry and Molecular Biology at Universitat Autònoma de Barcelona, has published a research on AKR1B10, an enzyme that is detected in large quantities only in lung cancers, particularly those caused by smoking. view more (2008-01-08)
Enzyme inhibitor takes an unexpected approach toward blocking cancer-promoting protein
Scientists at Fox Chase Cancer Center have discovered a unique method of attack that may be used to inhibit signaling enzymes called kinases, which often have a role in sustaining drug-resistant cancerous cells. They have confirmed that IPA-3, a small molecular inhibitor of a kinase called PAK1, targets the enzyme's regulatory domain, mimicking... view more... (2009-09-08)
U of I scientist develops enzyme inhibitor that may slow cancer growth
University of Illinois scientist Tim Garrow, in collaboration with Jiri Jiracek of the Czech Academy of Sciences, has applied for a provisional patent on a class of chemicals that has future therapeutic uses in medicine, specifically cancer treatment. view more (2006-07-07)
Inhibition of iron-metabolizing enzyme reduces tumor growth
A report in the Journal of Biological Chemistry shows that inhibition of heme oxygenase-1, an enzyme involved in iron metabolism, reduces Kaposi sarcoma tumor growth. view more (2006-04-21)
Alzheimer's drug based on Purdue-designed inhibitor begins clinical trials
A drug based on the design of a Purdue University researcher to treat Alzheimer's disease began the first phase of human clinical trials this week. view more (2007-06-25)
Enzyme is key to clogged arteries
Scientists at Queen Mary, University of London have made an important discovery in understanding what causes arteries to clog up. view more (2009-09-24)
p53, tumor suppression and aging
In the January 1 issue of Genes & Development, Dr. Mary Ellen Perry and colleagues validate the p53 inhibitor, Mdm2, as a promising target for cancer therapies. view more (2006-01-03)
Defeating the 'superpests'
Scientists have developed a new technique that makes pesticides more effective by removing insects' ability to exhibit resistance. view more (2005-10-10)
Insulin Pills
The issue of insulin-dependent diabetes has long been discussed. No wonder, as the problem concerns more than 5% of the world population. However, despite the enormous efforts and funds spent on its solution, the scientists so far have failed to replace the injections with pills. The difficulty is that insulin (like any other polypeptide) gets... view more... (2002-02-26)
New Weapon for Fighting Antibiotic Drug Resistance
The most important antibiotics in general use today are the b-lactam family of products, but the medical community faces a serious problem with these antibiotics: the increasing development of drug resistance. The resistance is caused by hydrolysis of the b-lactam by a bacterial lactamase enzyme, but fortunately it can often be overcome by the use... view more... (2003-08-11)
UCL study shows beans beat cancer
Scientists have discovered a new and potent anti-cancer compound in everyday food. The collaborative study led by UCL (University College London) shows that the compound-inositol pentakisphosphate-found in beans, nuts and cereals inhibits a key enzyme (phosphoinositide 3-kinase) involved in tumour growth. view more (2005-09-16)
Blood pressure drugs associated with reduced risk of esophageal, pancreatic and colon cancers
Thousands of individuals currently taking angiotension converting enzyme (ACE) inhibitors, a type of medication commonly used to lower blood pressure, may be doing more than treating their hypertension. view more (2006-05-24)
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