Enzyme Inhibitor Current Events | Enzyme Inhibitor News | 10
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Study details structural changes of a key catalytic enzyme
Enzymes are complex proteins capable of catalyzing specific biochemical reactions in cells. view more (2006-09-21)
Biochemical 'on-switch' could solve protein purification challenge
Drugs based on engineered proteins represent a new frontier for pharmaceutical makers. Even after they discover a protein that may form the basis of the next wonder drug, however, they have to confront a long-standing problem: how to produce large quantities of the protein in a highly pure state. view more (2009-10-23)
Cathepsin B increases apoptosis in fulminant hepatic failure
The traditional view is that hepatocyte necrosis is the main feature of fulminant hepatic failure, but increasing evidence implicates a dominant role for hepatocyte apoptosis in this pathogenesis. view more (2009-03-20)
UT Knoxville and ORNL researchers reveal key to how bacteria clear mercury pollution
Mercury pollution is a persistent problem in the environment. Human activity has lead to increasingly large accumulations of the toxic chemical, especially in waterways, where fish and shellfish tend to act as sponges for the heavy metal. view more (2009-10-02)
Texas A&M Researchers Examine How Viruses Destroy Bacteria
Viruses are well known for attacking humans and animals, but some viruses instead attack bacteria. Texas A&M University researchers are exploring how hungry viruses, armed with transformer-like weapons, attack bacteria, which may aid in the treatment of bacterial infections. view more (2009-11-19)
Using evolution, UW team creates a template for many new therapeutic agents
By guiding an enzyme down a new evolutionary pathway, a team of University of Wisconsin-Madison researchers has created a new form of an enzyme capable of producing a range of potential new therapeutic agents with anticancer and antibiotic properties. view more (2007-09-10)
Scientists discover way to block growth of prostate cancer cells
Scientists have discovered for the first time a specific biochemical pathway by which the sex hormone, androgen, increases levels of harmful chemicals called reactive oxygen species (ROS) in the prostate gland that play a role in the development of prostate cancer. view more (2006-11-08)
HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection
Researchers at the Tulane University School of Medicine, New Orleans, Louisiana have discovered that the HIV-1 protease inhibitors (PIs), such as nelfinavir included in highly active antiretroviral therapy (HAART) regimen for the treatment of HIV-1 patients, induce deleterious effects on insulin secretion mediated through the oxidative stress... view more... (2009-03-26)
Scientists develop new treatments for Alzheimer's disease
Scientists at the University of Liverpool have created a new chemical compound that could be developed into a drug treatment for Alzheimer's disease. view more (2006-10-27)
DNA size a crucial factor in genetic mutations, study finds
Researchers at Stanford University have created a larger-than-normal DNA molecule that is copied almost as efficiently as natural DNA. view more (2005-10-27)
Multiple sclerosis research charges ahead with new mouse model of disease
A new study highlights the role of a charge-switching enzyme in nervous system deficits characteristic of multiple sclerosis and other related neurological illness. view more (2008-11-06)
Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
Working with human colorectal cancer cells, a University of Minnesota team, led by cancer biologists Zigang Dong and Ann Bode, has found the potential culprit among a network of enzymes that relay signals inside cells to regulate such functions as cell growth, cancer development and programmed cell death. view more (2007-08-01)
Outsmarting cancer - new results from novel enzyme inhibitors
Smart drugs that can break the chain of command between enzymes and the genes involved in cell division and cell death are a new way forward in tackling breast cancer, according to Dr Stephen Johnston, a consultant oncologist from The Royal Marsden Hospital, London, UK. He was speaking at a news briefing on Thursday (21 March) at the 3rd European... view more... (2002-03-19)
Atomic-resolution views suggest function of enzyme that regulates light-detecting signals in eye
An atomic-resolution view of an enzyme found only in the eye has given researchers at the University of Washington (UW) clues about how this enzyme, essential to vision, is activated. view more (2008-10-08)
"Bad" Enzymes May Wear White Hats After Stroke
Enzymes that can harm the brain immediately after a stroke may actually be beneficial days later, according to new research. view more (2006-03-29)
New UW study offers strategy for treatment of fatal nervous system disorder
Working with mice, University of Wisconsin-Madison researchers have developed the basis for a therapeutic strategy that could provide hope for children afflicted with Krabbe's disease, a fatal nervous system disorder. view more (2005-12-13)
New therapy may mean less dietary restrictions for celiac sufferers
Scientists have discovered what may be a successful non-dietary therapy for celiac sprue, an inherited inflammatory disorder of the small intestine that impacts an estimated 1 in 200 people around the world. view more (2006-06-26)
Toxin detection as close as an inkjet printer
If that office inkjet printer has become just another fixture, it's time to take a fresh look at it. Similar technology may soon be used to develop paper-based biosensors that can detect certain harmful toxins that can cause food poisoning or be used as bioterrorism agents. view more (2009-07-14)
New use for a cell toxin found to inhibit survival proteins in cancer cells
A chemically-modified version of a mitochondrial toxin long used to control species of invasive fish in lakes has been found to selectively inhibit two "survival proteins" in cancer cells. view more (2007-07-12)
Hopkins researchers develop new tool to watch real-time chemical activity in cells
Attempts to identify potential drugs that interfere with the action of one particular enzyme linked to heart disease and similar health problems led scientists at Johns Hopkins to create a new tool and new experimental approach that allow them to see multiple, real-time chemical reactions in living cells. view more (2006-07-24)
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