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Experimental treatment halts hypoxic-ischemic brain injury in newborns
Inhibiting an enzyme in the brains of newborns suffering from oxygen and blood flow deprivation stops a type of brain damage that is a leading cause of cerebral palsy, mental retardation and death, according to researchers at Cincinnati Children's Hospital Medical Center. view more (2009-07-29)
New discovery may improve treatment of one of the world's leading causes of blindness
An inflammatory eye condition that is one of the world's leading causes of blindness could be treated much more effectively and easily thanks to a new discovery here. view more (2007-10-01)
Discovery of new protein could provide new understanding of male fertility
Scientists have discovered a new enzyme involved in the degradation of proteins inside cells, a process that helps eliminate or recycle proteins that are no longer needed. view more (2007-08-03)
Welcome Alternative To Warfarin For People At High Risk Of Stroke (pp 1686, 1691)
Results of an international study in this week's issue of THE LANCET provide strong evidence that the oral direct thrombin-inhibitor ximelagatran could be a safe and effective alternative to warfarin in reducing stroke among people with atrial fibrillation. Atrial fibrillation (irregular and rapidly beating atria) increases the risk of cardiac... view more... (2003-11-19)
'Corrective genes' closer thanks to enzyme modification
Scientists from the Université de Montréal and McGill University have re-engineered a human enzyme, a protein that accelerates chemical reactions within the human body, to become highly resistant to harmful agents such as chemotherapy, according to a new study published in The Journal of Biological Chemistry. view more (2009-07-29)
Cholera pathogen reveals how bacteria generate energy to live
Researchers at Rensselaer Polytechnic Institute have discovered new details about how bacteria generate energy to live. In two recently published papers, the scientists add key specifics to the molecular mechanism behind the pathogen that causes cholera. view more (2007-01-30)
Drug combo may reduce protease inhibitor-related hardening of the arteries
Physiologists may have found a way to decrease the risk of hardening of the arteries that accompanies the long-term use of protease inhibitors, a class of drugs that has emerged as the most effective treatment against HIV and AIDS. view more (2006-09-05)
Pazopanib shrinks lung cancers before surgery
Pazopanib, a new oral angiogenesis inhibitor, has demonstrated interesting activity in difficult to treat non-small-cell lung cancer, US researchers report. view more (2008-09-17)
New anthrax inhibitor could combat antibiotic-resistant strains
In a new approach to treating anthrax exposure, a team of scientists has created an inhibitor designed to tackle the growing threat of antibiotic-resistant strains. view more (2006-08-29)
Worth a thousand words: Hopkins researchers paint picture of cancer-promoting culprit
They say that a picture can be worth a thousand words. This especially is true for describing the structures of molecules that function to promote cancer. Researchers at Johns Hopkins have built a three-dimensional picture of an enzyme often mutated in many types of cancers. view more (2008-01-07)
Building memories with actin
Memories aren't made of actin filaments. But their assembly is crucial for long-term potentiation (LTP), an increase in synapse sensitivity that researchers think helps to lay down memories. view more (2009-07-13)
McGill researchers link enzyme to breast cancer malignancy
McGill University researchers have uncovered the crucial role played by the enzyme focal adhesion kinase (FAK) in the onset of breast cancer. view more (2007-11-30)
PET scan can non invasively measure early assessment of treatment for common type of breast cancer
Non-invasive imaging can measure how well patients with the most common form of breast cancer - estrogen receptor positive type - respond to standard aromatase inhibitor therapy after only two weeks and shows similar findings that more invasive needle sampling identifies, according to a poster presentation to be presented at the ASCO annual... view more... (2009-05-27)
UCSF study shows suppression of telomerase enzyme can inhibit spread of melanoma
UCSF researchers have found that the spread of melanoma can be inhibited by suppressing telomerase, the enzyme active in cancer cell growth. view more (2006-07-11)
What is the pathogenesis of liver damage induced by ethanol?
They investigated the effects of ethanol on the IGF-I system with the involvement of JNK1/2 activity and ADH by using each chemical inhibitor in primary cultured rat hepatocytes. The results indicate that ethanol inducedp-JNK1/2 activation is associated with the IGF-I system and cell viability in hepatocytes. view more (2008-10-08)
UCLA researchers reconstitute enzyme that synthesizes cholesterol drug lovastatin
Researchers from the UCLA Henry Samueli School of Engineering and Applied Science have for the first time successfully reconstituted in the laboratory the enzyme responsible for producing the blockbuster cholesterol-lowering drug lovastatin. view more (2009-11-04)
Blocking previously unrecognized links between inflammatory systems could make COX-2 inhibitors safe
A recently identified path of inflammation once thought to be wholly independent of other inflammatory systems has now been linked to another major pathway. view more (2005-12-23)
Frog molecule could provide drug treatment for brain tumours
Known as Amphinase, the molecule recognises the sugary coating found on a tumour cell and binds to its surface before invading the cell and inactivating the RNA it contains, causing the tumour to die. view more (2007-06-27)
Gladstone scientists reveal key enzyme in fat absorption
Scientists at the Gladstone Institutes of Cardiovascular Disease (GICD) have found that a key enzyme involved in absorbing fat may also be a key to reducing it. view more (2009-03-16)
UC Davis researchers shed new light on how chemotherapy-induced leukemia develops
Topoisomerase II inhibitors are among the most successful chemotherapy drugs used to treat human cancer. view more (2005-11-16)
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