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New understanding of COX-1 and COX-2 enzymes could lead to revised classification of pain meds, Queen's study shows COX-1 and COX-2 enzymes may be blocked by pain medications such as Advil and Vioxx in a more complex manner than was previously understood, a Queen's University study has found. view more (2006-05-30)
Catalyst mystery unlocked Different keys are not supposed to fit the same lock, but in biological systems multiple versions of a catalyst all make a reaction go, according to a new study that explains the phenomenon. view more (2008-08-19)
Researcher working on destruction of chemical weapons America's war on terror includes fighting the dark side of deadly chemical agents, and Texas A&M University chemist Dr. Frank Raushel is helping with the fight by developing an enzyme that might neutralize one such chemical agent, the organophosphates. view more (2008-09-25)
Purdue researcher invents molecule that stops SARS A Purdue University researcher has created a compound that prevents replication of the virus that causes SARS and could lead to a treatment for the disease. view more (2008-11-12)
Possible safer target for anti-clotting drugs found Researchers at the University of Illinois at Chicago College of Medicine have identified a new molecular target in blood clot formation, which seems to reduce clotting without excessive bleeding, the common side-effect of anti-clotting agents. view more (2007-09-27)
Newly discovered molecule promises better treatments for heart attacks, heart surgery Scientists have discovered a compound that could lead to new treatments for heart attacks as well as methods to protect hearts during open heart surgery and other situations in which blood flow to the heart is interrupted. view more (2008-09-12)
Lowering of Blood Pressure Reduces Risk of Recurrent Stroke (pp 1026, 1033) Combination drug treatment to lower blood pressure could substantially reduce the risk of recurrent stroke, conclude authors of a fast-track study published in this week's issue of The Lancet. Each year stroke effects 20 million people worldwide, kills 5 million people, and a third of 15 million non-fatal strokes result in severe disability. For... view more... (2001-09-26)
Study identifies potential drug target for Huntington's disease An enzyme known to be critical for the repair of damaged cells and the maintenance of cellular energy may be a useful target for new strategies to treat Huntington's disease (HD) and other disorders characterized by low cellular energy levels. view more (2006-07-31)
Structure of key enzyme in plague bacterium found Researchers at the National Institute of Standards and Technology (NIST) have solved the structure of a key enzyme from the bacterium responsible for plague, finding that it has a highly unusual configuration. The results may shed light both on how the bacterium kills and on fundamental cell signaling processes. view more (2006-08-21)
Alzheimer's disease therapeutic prevents long-term damage from TBI in pre-clinical studies A class of Alzheimer's disease drugs currently studied in clinical trials appears to reduce damage caused by traumatic brain injury in animals, researchers at Georgetown University Medical Center report in an upcoming advance online publication of Nature Medicine. view more (2009-03-16)
Researchers identify new weapon to fight deadly bacterial sepsis One of the most dangerous risks of contracting a serious bacterial infection is that the victim may develop sepsis-an overreaction by the immune system causing destructive inflammation throughout the body, often leading to heart and other organ failure and death. view more (2006-10-10)
Treating SSRI-Resistant Depression When your antidepressant medication does not work, should you switch to a different medication from the same class or should you try an antidepressant medication that has a different mechanism of action? This is the question asked by researchers in a new report scheduled for publication in Biological Psychiatry on April 1st. view more (2008-03-26)
Drug Offers New Options for Leukemia Patients Dasatinib, an experimental drug under development by Bristol-Myers Squibb, reverses the signs and symptoms of patients whose chronic myeloid leukemia has failed to respond to Gleevec, which is considered the standard of treatment for the disorder. view more (2006-06-15)
Rutgers researchers find fat gene Rutgers researchers have identified a gene - and the molecular function of its protein product - that provides an important clue to further understanding obesity and may point the way to new drugs to control fat metabolism. view more (2006-03-21)
Study shows vitamin C is essential for plant growth Scientists from the University of Exeter and Shimane University in Japan have proved for the first time that vitamin C is essential for plant growth. This discovery could have implications for agriculture and for the production of vitamin C dietary supplements. view more (2007-09-24)
Enzyme defect leads to hyperinsulinism A recent study in the Journal of Biological Chemistry confirms that mutations in an enzyme called glutamate dehydrogenase can cause congenital hyperinsulinism. view more (2006-05-25)
NEW THERAPEUTIC APPROACH TO CORONARY STENTING (p 2037) Patients given stent implantation to treat coronary heart disease could benefit from a new therapeutic approach with the platelet glycoprotein IIb/IIIa inhibitor eptifibatide, concludes research published in this week's issue of THE LANCET. The platelet glycoprotein IIb/IIIa inhibitors are potent inhibitors of blood clotting. They have previously... view more... (2000-12-13)
Computers worldwide speed search for anti-smallpox drugs A major computer project has been launched today to analyse millions of different chemicals in the search for drugs to combat the bioterrorist threat of smallpox. The smallpox research project will use the 'screensaver downtime' donated by up to two million computer users worldwide to screen 35 million compounds and identify those most likely to... view more... (2003-02-04)
Folate mystery finally solved Some biochemical processes, especially those in bacteria, have been so well studied it's assumed that no discoveries are left to be made. view more (2007-08-23)
Scientists identify possible cause of endometriosis Endometriosis is a condition whereby patches of the inner lining of the womb appear in parts of the body other than the womb cavity. It can cause severe pain and affects approximately 15% of women of reproductive age. Endometriosis is also associated with infertility, with 50% of infertile women affected by the condition. view more (2008-08-06)
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