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Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
Working with human colorectal cancer cells, a University of Minnesota team, led by cancer biologists Zigang Dong and Ann Bode, has found the potential culprit among a network of enzymes that relay signals inside cells to regulate such functions as cell growth, cancer development and programmed cell death. view more (2007-08-01)
Epigenetic research uncovers new targets for modification enzymes
Enzymes regulating genetic expression can be just as important as the genome itself, increasing evidence shows. The expanding field of epigenetics focuses on the multiple influences on DNA and surrounding molecules that determine whether genes are turned on or off during development and disease processes. view more (2008-04-28)
UCLA researchers reconstitute enzyme that synthesizes cholesterol drug lovastatin
Researchers from the UCLA Henry Samueli School of Engineering and Applied Science have for the first time successfully reconstituted in the laboratory the enzyme responsible for producing the blockbuster cholesterol-lowering drug lovastatin. view more (2009-11-04)
Atomic structure of the mammalian 'fatty acid factory' determined
Mammalian fatty acid synthase is one of the most complex molecular synthetic machines in human cells. It is also a promising target for the development of anti-cancer and anti-obesity drugs and the treatment of metabolic disorders. view more (2008-09-05)
Intelligently Designed Molecular Evolution
Evolutionary paths to new therapeutic drugs, as well as a wide assortment of other enzyme products, have been created through, of all things, intelligent design. A team of researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California at Berkeley have developed a technique in which the evolution of an... view more... (2006-02-24)
New drug agent knocks out multiple enzymes in cancer pathway
A team of 24 researchers from the U.S., Europe, Taiwan and Japan and led by University of Illinois scientists has engineered a new anti-cancer agent that is about 200 times more active in killing tumor cells than similar drugs used in recent clinical trials. view more (2009-03-26)
Phytochemicals may protect cartilage, prevent pain in joints
Johns Hopkins researchers have discovered that plant-derived compounds known for their ability to protect tissue also appear to block the activity of an enzyme that triggers inflammation in joints. view more (2005-10-04)
Dengue and other hemorrhagic fevers: Towards a first potential treatment
Globally, 60 to 100 million people are hit by Dengue, a viral disease transmitted by mosquitoes of the genus Aedes. The most severe form of this disease, which causes blood loss, can lead to a fatal shock-like state (Dengue Shock Syndrome) with or without associated haemorrhage, and is currently increasing in tropical countries. view more (2006-12-26)
Naturally fluorescent molecules may serve as cancer biomarker
Excess amounts of a naturally fluorescent molecule found in all living cells could serve as a natural biomarker for cancer, according to bioengineers. view more (2009-04-03)
A miR boost enables acute leukemia cells to mature
A new study by Ohio State University cancer researchers shows that boosting the level of a molecule called miR-29b in acute myeloid leukemia (AML) cells can reverse gene changes that trap the cells in an immature, fast growing state of development. view more (2009-04-03)
Molecular partners required for appropriate neuronal gene repression
In their efforts to understand the complex biology of life, scientists often seek to isolate individual elements of the puzzle for study, to break the problem down to a more manageable size. Single genes and molecules are closely analyzed to better understand their specific interactions with other single entities within larger systems. view more (2005-08-04)
Intestinal cells surprisingly active in pursuit of nutrition and defense
Every cell lining the small intestine bristles with thousands of tightly packed microvilli that project into the gut lumen, forming a brush border that absorbs nutrients and protects the body from intestinal bacteria. view more (2009-06-29)
Scientists determine structure of enzyme that disrupts bacterial virulence
A team of biomedical researchers from Brandeis University and the University of Texas at Austin has determined the first 3-dimensional structure of an enzyme that may be pivotal in preventing certain bacterial infections in plants, animals and humans. view more (2005-08-31)
The dynamic personalities of proteins reveal key traits
A Brandeis University study published in Nature this week advances fundamental understanding of the dynamic personalities of proteins and proposes that these enzymes are much more mobile, or plastic, than previously thought. view more (2005-11-04)
Scientists find a key culprit in stroke brain cell damage
Researchers have identified a key player in the killing of brain cells after a stroke or a seizure. The protein asparagine endopeptidase (AEP) unleashes enzymes that break down brain cells' DNA, scientists at Emory University School of Medicine have found. view more (2008-03-28)
Resistance to chemotherapy in lung cancer, optimizing flu vaccination strategies
Lung cancer is the most common cause of cancer-related death worldwide, in part because these tumors often are or become resistant to chemotherapy. view more (2006-10-03)
'Green' Plastics Could Help Reduce Carbon Footprint
More than 20 million tons of plastic are placed in U.S. landfills each year. Results from a new University of Missouri study suggest that some of the largely petroleum-based plastic may soon be replaced by a nonpolluting, renewable plastic made from plants. view more (2009-02-12)
£2.5M for research that will underpin the search for new antibiotics
The grants, which are both for periods of 5 years, total £2.5M. New antibiotics are urgently needed to maintain control of disease-causing bacteria, which are becoming resistant to more and more conventional antibiotics. view more (1999-10-12)
Study shows enzyme builds neurotransmitters via newly discovered pathway
The new study describes a pathway-different than the one previously suggested-for the biosynthesis of neurotransmitter lipids, N-acyl ethanolamines (NAEs), which include the endogenous cannabinoid ("endocannabinoid") anandamide. view more (2006-09-12)
Alternatives to the use of nitrate as a fertiliser
In order to develop sustainable agricultural production, what is required is a study of nitrogenated sources as alternatives to the nitrates that predominate in agricultural soils and that have a greater contaminant capacity. view more (2006-04-19)
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