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Epigenetic changes discovered in major psychosis
Scientists have discovered epigenetic changes (i.e. chemical changes to a gene that do not alter the DNA sequence) in individuals with schizophrenia and bipolar disorder. This is the first epigenome-wide investigation in psychiatric research, and this groundbreaking data may be a significant step... view more (2008-03-12)

USC researchers explore genetic causes for male infertility
Researchers at the University of Southern California (USC) suggest epigenetics, or the way DNA is processed and expressed, may be the underlying cause for male infertility. The study will be published in the Dec. 12 issue of Public Library of Science One.   view more (2007-12-12)

Epigenetics to shape stem cell future
Everyone hopes that one day stem cell-based regenerative medicine will help repair diseased tissue.   view more (2007-02-20)

First evidence that prenatal exposure to famine may lead to persistent epigenetic changes
A study initiated by researchers at Columbia University Mailman School of Public Health and the Leiden University Medical Center in the Netherlands suggests that prenatal exposure to famine can lead to epigenetic changes that may affect a person's health into midlife.   view more (2008-10-31)

Linking DNA and histone methylation
In the May 15th issue of G&D, Dr. Michael Carey (UCLA's Jonsson Comprehensive Cancer Center) and colleagues lend new insight into the mechanism of epigenetic silencing of euchromatic genes.   view more (2007-04-30)

Human embryonic stem cells remain embryonic because of epigenetic factors
A human embryonic stem cell is reined in - prevented from giving up its unique characteristics of self-renewal and pluripotency - by the presence of a protein modification that stifles any genes that would prematurely instruct the cell to develop into heart or other specialized tissue.   view more (2007-10-05)

New view of cancer: 'Epigenetic' changes come before mutations
A Johns Hopkins researcher, with colleagues in Sweden and at the Fred Hutchinson Cancer Research Center, suggests that the traditional view of cancer as a group of diseases with markedly different biological properties arising from a series of alterations within a cell's nuclear DNA may have to... view more (2005-12-22)

Computation to unravel how genes are regulated and shed light on how cells become different
A closer alliance between computational and experimental researchers is needed to make progress towards one of biology's most challenging goals, understanding how epigenetic marks contribute to regulation of gene expression.   view more (2008-04-11)

Our genome changes over lifetime, Johns Hopkins experts say
Researchers at Johns Hopkins have found that epigenetic marks on DNA-chemical marks other than the DNA sequence-do indeed change over a person's lifetime, and that the degree of change is similar among family members.   view more (2008-06-25)

Study links breast cancer risk to epigenetic changes related to race, smoking and birth size
Women can encounter environmental factors that increase their risk of breast cancer at various periods of their physical development, beginning before birth and extending until menopause.   view more (2007-04-16)

'Smothered' genes combine with mutations to yield poor outcome in cancer patients
Johns Hopkins Kimmel Cancer Center researchers have identified a set of genes in breast and colon cancers with a deadly combination of traditional mutations and "smothered" gene activity that may result in poor outcomes for patients.   view more (2008-07-16)

Child abuse may 'mark' genes in the brains of suicide victims
A team of McGill University scientists has discovered important differences between the brains of suicide victims and so-called normal brains. Although the genetic sequence was identical in the suicide and non-suicide brains, there were differences in their epigenetic marking - a chemical coating... view more (2008-05-07)

New prostate cancer marker helps identify men whose cancer is likely to spread
Prostate cancer researchers at Sydney's Garvan Institute, supported by the Cancer Institute NSW, have found a new marker for identifying aggressive prostate cancers.   view more (2006-10-04)

Liposuctioned fat stem cells to repair bodies
Expanding waistlines, unsightly bulges: people will gladly remove excess body fat to improve their looks. But unwanted fat also contains stem cells with the potential to repair defects and heal injuries in the body.   view more (2007-02-23)

Epigenetic research uncovers new targets for modification enzymes
Enzymes regulating genetic expression can be just as important as the genome itself, increasing evidence shows. The expanding field of epigenetics focuses on the multiple influences on DNA and surrounding molecules that determine whether genes are turned on or off during development and disease... view more (2008-04-28)

How schizophrenia develops: Major clues discovered
Schizophrenia may occur, in part, because of a problem in an intermittent on/off switch for a gene involved in making a key chemical messenger in the brain, scientists have found in a study of human brain tissue.   view more (2007-10-17)

Height has been linked to long life for many centuries
It is now well known that tall people tend to live longer, but has this always been the case? A study of skeletal remains dating back to the 9th century published in the Journal of Epidemiology and Community Health concludes that short bones have always been a marker of a short life, despite... view more (2001-06-12)

Study finds genomic changes in the brains of people who commit suicide
Are genes destiny? Alternatively, are we simply the products of our environment? There is a growing sense that neither of these two possibilities fully captures the essence of the risk for psychiatric disorders.   view more (2008-10-23)

Subtle changes in normal genes implicated in breast cancer
Using a super-efficient method they invented to search for a type of cancer-related change in all genes of a cell, Dana-Farber Cancer Institute researchers have discovered new evidence about how the "microenvironment" of breast cancers helps drive the cancers' growth and migration.   view more (2005-07-14)

Protein marker for schizophrenia risk
A protein found in immune cells may be a reliable marker for schizophrenia risk, report researchers in a new proteomics study appearing in the July issue of Molecular and Cellular proteomics.    view more (2008-07-09)

Human embryonic stem cells display a unique pattern of chemical modification to DNA
Scientists from the Burnham Institute for Medical Research (BIMR) and Illumina Inc., in collaboration with stem cell researchers around the world, have found that the DNA of human embryonic stem cells is chemically modified in a characteristic, predictable pattern.   view more (2006-08-07)

Breast cancer : Discovery of a new tumor marker
At the Curie Institute in Paris, CNRS researchers have discovered a new proliferation marker : the CAF-1 complex. Since deregulated cell proliferation is one of the most characteristic features of tumor cells, this discovery represents a breakthrough in the cancer field. The researchers from the... view more (2004-03-30)

Cancer scientists call for a large-scale human epigenome project
A vast code, invisible to the DNA sequencing effort that constituted the Human Genome Project, is rapidly being shown to play a direct role in human health. This "epigenome"-from the Greek epi, meaning "in addition to"-consists of chemical "amendments" that dangle like... view more (2005-12-15)

USC study in Nature Genetics supports a stem cell origin of cancer
Researchers at the University of Southern California (USC) recently made significant strides toward settling a decades-old debate centering on the role played by stem cells in cancer development.   view more (2007-01-10)

High circulating D-dimers are associated with presence of ascites
The liver is the production site of most of the proteins which favour and inhibit the process of coagulation and fibrinolysis.   view more (2008-04-30)
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