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Epigenetic Silencing Current Events | Epigenetic Silencing News
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Linking DNA and histone methylation
In the May 15th issue of G&D, Dr. Michael Carey (UCLA's Jonsson Comprehensive Cancer Center) and colleagues lend new insight into the mechanism of epigenetic silencing of euchromatic genes. view more (2007-04-30)
Plants display 'molecular amnesia'
Plant researchers from McGill University and the University of California, Berkeley, have announced a major breakthrough in a developmental process called epigenetics. They have demonstrated for the first time the reversal of what is called epigenetic silencing in plants. view more (2008-12-03)
Silence please
Researchers at Cambridge University have been studying the process of gene silencing in transgenic plants, and have cloned a genetic modifier that could reduce transgene instability. Dr Ian Furner will be presenting the results of the study at the Society for Experimental Biology conference on Monday 8 April. view more (2002-04-04)
Protein protects anti-cancer gene from chemical shutdown
A protein that is largely absent in one type of skin cancer protects an important gene in a cell's defense against harmful mutations from being silenced. view more (2007-07-20)
CSHL scientists discover how 'companion' cells to sperm protect them from genetic damage
In plant pollen grains, sperm cells, which carry the genetic material to be passed on to progeny, are cocooned within larger "companion" cells that are called pollen vegetative cells. These companions provide sperm with energy and nourishment, and push them towards their targets during fertilization. view more (2009-02-06)
Epigenetic changes discovered in major psychosis
Scientists have discovered epigenetic changes (i.e. chemical changes to a gene that do not alter the DNA sequence) in individuals with schizophrenia and bipolar disorder. This is the first epigenome-wide investigation in psychiatric research, and this groundbreaking data may be a significant step on the journey to fully understanding major... view more... (2008-03-12)
Non-coding RNAs help silence the mammalian transcription
Dr. Shirley Tilghman and colleagues (Princeton University) lend new insight into the mechanism of genomic imprinting, demonstrating a necessary role for a non-coding RNA transcript in the silencing of an imprinted gene cluster in mice. view more (2006-05-15)
USC study in Nature Genetics supports a stem cell origin of cancer
Researchers at the University of Southern California (USC) recently made significant strides toward settling a decades-old debate centering on the role played by stem cells in cancer development. view more (2007-01-10)
USC researchers explore genetic causes for male infertility
Researchers at the University of Southern California (USC) suggest epigenetics, or the way DNA is processed and expressed, may be the underlying cause for male infertility. The study will be published in the Dec. 12 issue of Public Library of Science One. view more (2007-12-12)
In lung cancer, silencing one crucial gene disrupts normal functioning of genome
While examining patterns of DNA modification in lung cancer, a team of international researchers has discovered what they say is a surprising new mechanism. view more (2009-01-05)
Gene shut-down may offer early warning of chronic leukemia
A new study shows that certain genes are turned off early, before clinical signs of the disease appear, in the development of chronic leukemia. view more (2009-08-06)
Silencing the cause of mad cow disease
BSE (more commonly known as mad cow disease) and CJD, which is a related disease in humans that can occur spontaneously, be inherited, or be acquired (in some cases probably from cows with BSE), are fatal neurodegenerative diseases. view more (2006-12-04)
Human embryonic stem cells remain embryonic because of epigenetic factors
A human embryonic stem cell is reined in - prevented from giving up its unique characteristics of self-renewal and pluripotency - by the presence of a protein modification that stifles any genes that would prematurely instruct the cell to develop into heart or other specialized tissue. view more (2007-10-05)
Epigenetics to shape stem cell future
Everyone hopes that one day stem cell-based regenerative medicine will help repair diseased tissue. view more (2007-02-20)
New genes involved in Acute Lymphoblastic Leukemia play fundamental role in prognosis of the disease
The inactivity or "silence" of certain genes plays a fundamental role in the prognosis of acute lymphoblastic leukemia (ALL) as well as in response to treatment, according to the results of research involving a team made up of specialists from the University Hospital of Navarra and the Centre for Applied Medical Research (CIMA) at the... view more... (2009-02-09)
Cancer cells suppress large regions of DNA by a reversible process that can be tackled
Cancer researchers at Sydney's Garvan Institute, in collaboration with Spanish scientists, have formulated a new concept for how cancer cells can escape normal growth controls, which may have far-reaching implications for the new generation of cancer therapies. view more (2006-04-24)
Researchers may have unlocked the mechanisms that silence the estrogen receptor gene alpha during breast cancer
The mechanisms that silence the estrogen receptor gene alpha (ER-α) in certain breast cancer cell lines may be closer to being unlocked. view more (2007-08-20)
Identified mechanism in the malaria parasite to help it adapt to infected individuals
Plasmodium falciparum is responsible for the most severe forms of human malaria. Invasion of host red blood cells is an essential step of the complex life cycle of this parasite. view more (2007-08-03)
Ali Shilatifard and Colleagues Aim to Clarify the Definition of "Epigenetics"
Ali Shilatifard, Ph.D., Investigator, has joined with a team of colleagues to propose an operational definition of "Epigenetics" - a rapidly growing research field that investigates heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence. view more (2009-04-02)
Norwich scientist receives prestigious international science prize
"I am very pleased that the work of my group has been recognised by this award", said Professor David Baulcombe. "I am also delighted to see that research into plants has been acknowledged. It is often forgotten that plants are excellent models for many types of genetic and biochemical research. Beijerincks discovery of viruses in... view more... (2004-10-28)
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