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The new source of islet cells
The shortage of islet cells limits the development of islet transplantation. One new approach was reported in the October 21 issue of the World Journal of Gastroenterology because of its great significance in enhancing the output of islet cells. This article will undoubtedly bring benefit to... view more (2007-10-25)

Master regulatory gene of epithelial stem cells identified
The skin's ability to replace the tissue it sloughs off is controlled by a variety of genes. A new study from Harvard Medical School published in the May 4 issue of Cell, however, identifies a "master regulator" of this regeneration process not only for skin, but for many epithelial... view more (2007-05-04)

iNOS expression may links chronic biliary inflammation to malignant transformation
It is well known that chronic biliary inflammation is a risk factor for biliary carcinogenesis. However, the molecular mechanisms of biliary carcinogenesis as a consequence of chronic biliary inflammation remain unclear.   view more (2007-12-20)

Cells united against cancer
Sheets of highly organized epithelial cells line all the cavities and free surfaces of the body, forming barriers that control the movement of liquids and cells in the body organs.   view more (2007-08-28)

Histochemistry is the golden standard in the diagnosis of carcinosarcomas
A case study of carcinosarcoma has been published in the World Journal of Gastroenterology on November 7, 2007. The patient in the study was the first case of gastric carcinosarcoma obtained in this part of the world.   view more (2007-11-15)

Stomach receptor for H. pylori discovered
Scientists have determined that decay-accelerating factor (DAF), a protein found in epithelial cells in the stomach, acts as a receptor for the bacteria Helicobacter pylori.   view more (2006-05-05)

Low cholesterol cues cataract development
Cataracts are a leading cause of blindness worldwide. Using a rat model of cataract formation, Masayuki Mori and researchers at Shinshu University Graduate School of Medicine in Japan have now found a link between cataracts and cholesterol.   view more (2006-01-27)

Newly discovered behavior in cancer cells signals dangerous metastasis
The most aggressively malignant cancer cells have a "toggle switch" that enables them to morph into highly mobile cells that invade other tissues and then nest comfortably in their new surroundings, a new study in rats suggests.   view more (2006-09-18)

Gaps in intestinal barrier could cause Crohn's disease
Scientists at the University of Liverpool believe gaps in the intestinal barrier could be a cause of inflammatory diseases of the gut such as Crohn's Disease.   view more (2005-09-16)

Promising cell protein may play role in infection and dry eye
Plasminogen Activator Inhibitor Type 2 (PAI-2), a protein found in various cell types including the skin, has been discovered in the tissue covering the eye and may have future clinical implications in various pathologies of the ocular surface such as eye infection or dry eye.   view more (2006-05-17)

Study: Harmless virus kills some cancers
Six days is all it takes for a common, non-disease-causing virus to kill cervical, breast, prostate and squamous cell cancer cells in laboratory cultures, according to Penn State College of Medicine researchers.   view more (2005-06-22)

Selective marker found to indicate aggressive form of breast cancer
Researchers have linked a structural protein called nestin to a particularly deadly form of breast cancer, identifying a new biomarker that could lead to earlier detection and better treatment.   view more (2007-01-15)

Helicobacter pylori - the key behind its recognition is somewhere else
The first step against infection is the detection of microorganisms capable of causing disease. This is done through the recognition of molecular structures not shared by the host, but also present in other harmless or even useful microbes. A question that has puzzled scientists for many years is... view more (2004-10-29)

Gains in the fight against acid aspiration lung injury
Doctors are gaining new leverage in the fight against lung injury caused by acid reflux. The paper by Bonnans et al., "Lipoxin A4 regulates bronchial epithelial cell responses to acid injury," appears in the April issue of The American Journal of Pathology and is accompanied by a... view more (2006-05-03)

Researchers identify molecular basis of inflammatory bowel disease
Inflammatory bowel diseases, such as Crohn's disease and Ulcerative Colitis, severely impair the lives of more than four million people worldwide. The development of effective therapies against these diseases requires an understanding of their underlying molecular mechanisms. Researchers from the... view more (2007-03-15)

Discarded placentas deliver researchers promising cells similar to embryonic stem cells
Routinely discarded as medical waste, placental tissue could feasibly provide an abundant source of cells with the same potential to treat diseases and regenerate tissues as their more controversial counterparts, embryonic stem cells.   view more (2005-08-08)

Research details how a virus hijacks cell signals to cause infection
A common virus that causes meningitis and heart inflammation takes a "back door" approach to evade natural barriers, then exploits biological signals to infect human cells.   view more (2006-01-13)

Stem cells provide clues to cancer spread
Scientists have made a breakthrough in understanding how cancers spread in what could lead to new ways of beating the disease.   view more (2007-05-23)

Protein maintains cross talk between cells that control hair growth
Genes, it turns out, are only as active as the signals that turn them on and off. Now scientists from Rockefeller University and the Howard Hughes Institute have identified the signaling molecule that ratchets up and clamps down the activity of key genes in dermal papilla, a type of skin cell whose... view more (2008-02-15)

Cellular pathway yields potential new weapon in vaccine arsenal
When a cell has to destroy any of its organelles or protein aggregates, it envelopes them in a membrane, forming an autophagosome, and then moves them to another compartment, the lysosome, for digestion. Two years ago, Rockefeller University assistant professor Christian Münz showed that this... view more (2006-12-27)

New developments in biomarkers for epithelial ovarian cancer
With the genomic revolution radical improvement has been made in methods of detection of ovarian cancer.   view more (2007-11-30)

Two-faced protein can stop metastasis or promote it, researchers say
A protein known to be a key component of the glue that holds cells together also is involved in breaking them apart and promoting their movement when tumors begin to spread to other parts of the body, researchers at Mayo Clinic have found.   view more (2006-09-19)

Researchers writing story of the 'alcoholic lung'
Chronic alcohol abuse disrupts the proteins that keep fluids out of the lung, lowers a protective antioxidant, disrupts immune defenses and can lead to a condition known as 'alcoholic lung,' according to research to be presented at the conference, "Physiological Genomics and Proteomics of Lung... view more (2006-11-03)

Cancer support cells may evolve, fuel tumor growth, study shows
University of North Carolina at Chapel Hill scientists have demonstrated in a living organism that cancers may cause surrounding supportive cells to evolve and ultimately promote cancer growth.   view more (2005-12-19)

Protein-Dependent "Switch" Regulates Intracellular Trafficking in Epithelial Cells
With findings highlighted on a recent cover of Developmental Cell, researchers at Weill Cornell Medical College in New York City have shed important new light on key trafficking mechanisms within epithelial cells. Epithelial cells line the outside of nearly all organs.   view more (2007-12-12)
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