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What is the function of NOD2 in colonic epithelial cells?
NOD2 is a cytosolic pattern recognition receptor similar in structure and function to Toll like receptors (TLRs). It can recognize and respond to a component found in the cell wall of bacteria, muramyl dipeptide (MDP), and has been shown to play an important role in the innate immune response of macrophages to bacterial infections.   view more (2008-10-23)

The new source of islet cells
The shortage of islet cells limits the development of islet transplantation. One new approach was reported in the October 21 issue of the World Journal of Gastroenterology because of its great significance in enhancing the output of islet cells. This article will undoubtedly bring benefit to diabetic patients.   view more (2007-10-25)

Scientists identify new role for lung epithelial cells in sensing allergens in the air
Researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and at Ghent University in Ghent, Belgium, have identified a new role for certain lung cells in the immune response to airborne allergens.   view more (2009-03-31)

Master regulatory gene of epithelial stem cells identified
The skin's ability to replace the tissue it sloughs off is controlled by a variety of genes. A new study from Harvard Medical School published in the May 4 issue of Cell, however, identifies a "master regulator" of this regeneration process not only for skin, but for many epithelial tissues including breast, prostate, and urogenital... view more... (2007-05-04)

iNOS expression may links chronic biliary inflammation to malignant transformation
It is well known that chronic biliary inflammation is a risk factor for biliary carcinogenesis. However, the molecular mechanisms of biliary carcinogenesis as a consequence of chronic biliary inflammation remain unclear.   view more (2007-12-20)

Cells united against cancer
Sheets of highly organized epithelial cells line all the cavities and free surfaces of the body, forming barriers that control the movement of liquids and cells in the body organs.   view more (2007-08-28)

Alcohol activates cellular changes that make tumor cells spread
Alcohol consumption has long been linked to cancer and its spread, but the underlying mechanism has never been clear.    view more (2009-10-27)

Study shows how disruption of spectrin-actin network causes lens cells in the eye to lose shape
A network of proteins underlying the plasma membrane keeps epithelial cells in shape and maintains their orderly hexagonal packing in the mouse lens, say Nowak et al.   view more (2009-09-14)

Histochemistry is the golden standard in the diagnosis of carcinosarcomas
A case study of carcinosarcoma has been published in the World Journal of Gastroenterology on November 7, 2007. The patient in the study was the first case of gastric carcinosarcoma obtained in this part of the world.   view more (2007-11-15)

UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs
New research from UC Davis Cancer Center shows that a protein called Muc4 may be the essential ingredient that allows breast cancer to spread to other organs and resist therapeutic treatment.   view more (2009-04-02)

Stomach receptor for H. pylori discovered
Scientists have determined that decay-accelerating factor (DAF), a protein found in epithelial cells in the stomach, acts as a receptor for the bacteria Helicobacter pylori.   view more (2006-05-05)

Low cholesterol cues cataract development
Cataracts are a leading cause of blindness worldwide. Using a rat model of cataract formation, Masayuki Mori and researchers at Shinshu University Graduate School of Medicine in Japan have now found a link between cataracts and cholesterol.   view more (2006-01-27)

Mayo researchers discover mechanism of cell type-specific signaling in tumor development
Mayo Clinic researchers have discovered the mechanisms behind two key checkpoints in cell growth and development - factors that may ultimately allow investigators to benchmark progression of tumor cells or stop them from further development. The findings appear in the current online issue of Developmental Cell.   view more (2009-04-08)

Newly discovered behavior in cancer cells signals dangerous metastasis
The most aggressively malignant cancer cells have a "toggle switch" that enables them to morph into highly mobile cells that invade other tissues and then nest comfortably in their new surroundings, a new study in rats suggests.   view more (2006-09-18)

Gaps in intestinal barrier could cause Crohn's disease
Scientists at the University of Liverpool believe gaps in the intestinal barrier could be a cause of inflammatory diseases of the gut such as Crohn's Disease.   view more (2005-09-16)

Fibroblasts invade at a snail's pace
A transcription factor known to drive the formation of fibroblasts during development also promotes their ability to invade and remodel surrounding tissues, report Rowe et al. in the February 9, 2009 issue of the Journal of Cell Biology.   view more (2009-02-02)

Research elucidates way lungs fight bacteria and prevent infection
Actor and pancreatic cancer patient Patrick Swayze's recent hospitalization with pneumonia as a result of his compromised immune system underscores the sensitivity of the lungs: many patients die from lung complications of a disease, rather than the disease itself.   view more (2009-01-23)

Master Molecular Switch May Prevent the Spread of Cancer Cells to Distant Sites in the Body, According to Penn Study
Researchers at the University of Pennsylvania School of Medicine have identified a master switch that might prevent cancer cells from metastasizing from a primary tumor to other organs. The switch is a protein that, when in the "on" position, maintains the normal character of cells that line the surface of organs and body cavities.   view more (2009-03-17)

Lung cancer suppresses miR-200 to invade and spread
Primary lung cancer shifts to metastatic disease by suppressing a family of small molecules that normally locks the tumor in a noninvasive state, researchers at The University of Texas M. D. Anderson Cancer Center report in the Sept. 15 edition of Genes and Development.   view more (2009-09-15)

Promising cell protein may play role in infection and dry eye
Plasminogen Activator Inhibitor Type 2 (PAI-2), a protein found in various cell types including the skin, has been discovered in the tissue covering the eye and may have future clinical implications in various pathologies of the ocular surface such as eye infection or dry eye.   view more (2006-05-17)
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