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Study helps explain why botulinum toxin is so deadly
A pilot without a map can locate an airport by first finding a nearby landmark, like a big river, and then searching for the airport.   view more (2006-12-14)

Analysis reveals extent of DNA repair army
Cells have the remarkable ability to keep track of their genetic contents and -- when things go wrong " to step in and repair the damage before cancer or another life-threatening condition develops.   view more (2007-05-25)

Cell surface receptors are all 'talk' in T cell stimulation
Understanding the mechanisms that drive healthy immune responses is important when it comes to combating autoimmune diseases, which occur when cells that should attack invading organisms turn on the body instead.   view more (2008-06-13)

Immune system discovery could aid fight against TB
A key aspect of how the body kicks the immune system into action against tuberculosis is revealed in research published today.   view more (2006-10-23)

DNA highly-promising predictor for successful treatment of alcoholics
According to Dutch researcher Wendy Ooteman, the biological and genetic characteristics of alcoholics can predict which drugs will best suppress the desire to drink.    view more (2006-10-05)

Alteration of brain protein regulates learning
Researchers at UT Southwestern Medical Center have identified a biochemical switch that affects how neurons fire in a part of the brain associated with learning, findings that may aid in understanding schizophrenia and Alzheimer's disease.   view more (2005-08-18)

Cancer Researchers at the University of Pennsylvania Discover What Makes Lymphomas Tick
University of Pennsylvania researchers and their colleagues at the Wistar Institute and University of Oxford have discovered the molecular process by which the PAX5 protein, necessary for lymphocyte development, promotes the growth of common lymphomas, thereby unveiling a potential new target in... view more (2007-08-30)

Gene variation affects tamoxifen's benefit for breast cancer
One of the most commonly prescribed drugs for breast cancer, tamoxifen, may not be as effective for women who inherit a common genetic variation, according to researchers at the University of Michigan and the Mayo Clinic.   view more (2005-12-19)

Novel enzyme offers new look at male hormone regulation
For the second time in less than a year, University of North Carolina at Chapel Hill scientists have purified a novel protein and have shown it can alter gene activity by reversing a molecular modification previously thought permanent.   view more (2006-05-08)

New weapon in battle against osteoporosis
Medical researchers at the University of Bonn, working in collaboration with scientists from Israel, the USA and Britain, have identified a previously unknown regulatory mechanism in the process of bone loss. Their findings could open up new approaches to the treatment of osteoporosis.   view more (2006-01-03)

Researchers reveal how long-term use of anti-inflammatory medication can cause osteoporosis
The steroid hormones glucocorticoids (GCs) are used at high doses to treat inflammatory and immune disorders, however they prompt bone loss and can cause osteoporosis, particularly when administered for prolonged periods.   view more (2006-07-28)

Gene profiling predicts resistance to breast cancer drug Herceptin
Using gene chips to profile tumors before treatment, researchers at Harvard and Yale Universities found markers that identified breast cancer subtypes resistant to Herceptin, the primary treatment for HER2-positive breast cancer.   view more (2007-02-21)

Nicotine rush hinges on sugar in neurons
When nicotine binds to a neuron, how does the cell know to send the signal that announces a smoker's high"   view more (2007-07-23)

Zinc plays important role in brain circuitry
To the multitude of substances that regulate neuronal signaling in the brain and spinal cord add a new key player: zinc. By engineering a mouse with a mutation affecting a neuronal zinc target, researchers have demonstrated a central role for zinc in modulating signaling among the neurons.   view more (2006-11-27)

Biologists visualize protein interaction that may initiate viral infection
Biologists at Purdue University have taken a "snapshot" of a Velcro-like protein on a cell's surface just after it attached to the dengue virus, a linkup thought to initiate the early stages of infection.   view more (2006-02-10)

New target for obesity and related metabolic disorders
A new study reveals an attractive new target for therapies aimed at the treatment of obesity and related metabolic disorders, researchers report in the March Cell Metabolism.   view more (2006-03-08)

Scientists identify fundamental brain defect, probable drug target in fragile X syndrome
Scientists have discovered how the gene mutation responsible for fragile X syndrome--the most common inherited form of mental retardation--alters the way brain cells communicate.   view more (2007-09-18)

Carnegie Mellon, USDA report that Fe-TAML® catalysts degrade estrogenic compounds
Scientists from Carnegie Mellon University and the U.S. Department of Agriculture (USDA) have found that a rapid, environmentally friendly catalytic process involving Fe-TAML® activators and hydrogen peroxide breaks down two types of estrogenic compounds.   view more (2006-06-27)

Genetic variant linked to odor perception
Why the same sweaty man smells pleasant to one person and repellant to another comes down to the smeller's genes.   view more (2007-09-17)

Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer link noted
Being obese increases the risk of breast cancer in post-menopausal women, shortens the time between return of the disease and lowers overall survival rates.   view more (2007-04-30)

Study Demonstrates Safety of Oral Contraceptives in Women with Lupus
In a major study, women with either inactive or stable systemic lupus erythematosus (lupus) - a disease in which the body's immune system mistakenly attacks and damages healthy tissues of the skin, joints and internal organs - were able to take oral contraceptives without increased risk of flares,... view more (2005-12-23)

Stopping a receptor called 'nogo' boosts the synapses
New findings about a protein called the nogo receptor are offering fresh ways to think about keeping the brain sharp.   view more (2008-03-19)

Research uncovers signaling pathways related to brain-immune system links
New research on signaling pathways in immune cells bolsters evidence of connections between the central nervous system and the immune system.   view more (2006-05-16)

The tachykinin receptor 3 gene has been linked to alcohol and cocaine dependence
The search for genes associated with alcohol dependence has recently been extended to the tachykinin receptor 3 gene, located within a broad region on chromosome 4q. Researchers have found that seven of the nine single nucleotide polymorphisms -- DNA sequence variations -- in the 3' region of TACR3... view more (2008-05-06)

Manipulating Cell Receptor Alters Animal Behavior
Researchers at the University at Buffalo and the University of Pennsylvania were the first to demonstrate that two intracellular events, both stimulated by the same cell receptor, can provoke different behaviors in mammals.   view more (2006-03-22)
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