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Study shows enzyme builds neurotransmitters via newly discovered pathway
The new study describes a pathway-different than the one previously suggested-for the biosynthesis of neurotransmitter lipids, N-acyl ethanolamines (NAEs), which include the endogenous cannabinoid ("endocannabinoid") anandamide.   view more (2006-09-12)

Pre-clinical studies identify novel ways to enhance effect of chemotherapy
Results call for clinical trials with Glivec in combination with other chemotherapy Frankfurt, Germany: Researchers have found that blocking the action of a growth factor on tumour stroma cells[1] increases the uptake of cancer drugs by the tumour. The findings could be crucial for efforts to make... view more (2002-11-17)

Neuronal Receptor Response May Help Explain Alzheimer's Memory Loss
Based on laboratory research, scientists at Georgetown University Medical Center have a new theory as to why people with Alzheimer's disease have trouble performing even the simplest memory tasks, such as remembering a family member's name.   view more (2006-02-13)

Joslin-led study reveals findings on how insulin-producing beta cells grow and function
Joslin-led study reveals findings on how insulin-producing beta cells grow and function   view more (2006-04-24)

Contribution of cholesterol transporter to vascular disease
Low-density lipoprotein (LDL), a transporter of cholesterol, may also contribute to vascular diseases by a previously unidentified mechanism, according to a report published online this week in EMBO reports.   view more (2007-10-26)

Global view shows link between endometrial cancer and vitamin D status
Using newly available data on worldwide cancer incidence, researchers at the Moores Cancer Center at University of California, San Diego (UCSD) have shown a clear association between deficiency in exposure to sunlight, specifically ultraviolet B (UVB), and endometrial cancer.   view more (2007-11-15)

Study shows drug effective in treating, preventing breast cancer
A new study of an estrogen-derived drug shows promise as a treatment for breast cancer and breast cancer metastases to bone.   view more (2007-11-01)

Gene against bacterial attack unravelled
Dutch researcher Joost Wiersinga from AMC Medical Centre in Amsterdam has unravelled a genetic defence mechanism against the lethal bacteria Burkholderia pseudomallei. The research is the next step towards a vaccine against this bacterium suitable for bioweapons.   view more (2008-10-29)

Protein Plays Critical Role in Heart Failure in Both the Heart and Adrenal Gland
A protein that plays an important regulatory role in heart failure in the heart also exerts powerful effects on the adrenal gland, Jefferson Medical College researchers have found.   view more (2005-11-16)

EARLY PROMISE FOR TREATMENT OF PULMONARY HYPERTENSION (pp 1113, 1119)
Encouraging results of a randomised trial in this week’s issue of THE LANCET suggest that the drug bosentan could play an important future role in the treatment of pulmonary hypertension. Pulmonary hypertension (raised pressure in the blood vessels supplying the lungs) causes thickening of... view more (2001-10-03)

Older breast cancer patients may be under-diagnosed and under-treated
Elderly patients with breast cancer who received care in a community hospital setting may have been under-diagnosed, under-staged and under-treated.   view more (2006-10-17)

Opioids and cannabinoids influence mobility of spermatozoids
A PhD thesis from the University of the Basque Country has concluded that there are opioid and cannabinoid receptors in human sperm and that these influence the mobility of spermatozoid.   view more (2008-06-23)

Cocaine: How addiction develops
Permanent drug seeking and relapse after renewed drug administration are typical behavioral patterns of addiction. Molecular changes at the connection points in the brain's reward center are directly responsible for this.   view more (2008-08-22)

UK researcher finds 'switching' compound for angiogenesis
For the second time in a week Dr. Jayakrishna Ambati, UK HealthCare physician and associate professor and vice chair of the Department of Ophthalmology and Visual Sciences, announced a discovery from his lab that will affect the future of macular degeneration treatment and research.   view more (2006-02-03)

Research suggests aspirin helps combat cataracts
Ongoing research in the School of Animal and Microbial Sciences (AMS) at the University of Reading has helped to clarify the process of cataract, the largest cause of blindness in the world. Professor James Crabbe and his team in AMS have targeted the importance of non-steroidal anti-inflammatory... view more (2004-06-03)

Researchers find docking sites for glucocorticoid receptor and Hsp90
University of Oregon researchers have identified protein interactions that regulate the response of cells to steroid hormones. The discovery, they say, could lead to new ways to boost the effectiveness and reduce undesired side effects of steroid-hormone treatments and cancer drugs.   view more (2006-11-21)

New research: Soy germ isoflavones reduce bone loss
A new study published in this month's European Journal of Nutrition demonstrates a strong correlation between reducing bone loss in non-obese postmenopausal women and the dose-dependent effect of soy germ isoflavones.   view more (2006-07-07)

EGF receptor activation prevents microbes from going more than skin deep
Our skin not only serves as a physical barrier against infection but skin cells themselves can mount an immune response to kill invading microbes by producing antimicrobial polypeptides (AMPs).   view more (2006-06-16)

New clues to how major weight-loss drugs work
Some of the most important weight-loss drugs work by enhancing the effect of the brain chemical serotonin. These include sibutramine (trade name Meridia) and fenfluramine, which was recalled after the combination with dexfenfluramine, called fen-phen, was linked to potentially fatal heart valve... view more (2006-07-20)

Tendency to hair loss inherited from the mother
The male sex hormones really do seem to play a decisive role in causing hair loss in men. This has been confirmed by scientists from the universities of Bonn and Düsseldorf. Their studies show that specific changes in the genetic 'construction manual' of the androgen receptor may result in... view more (2005-05-20)

“Shooting the messenger” to tackle autoimmune diseases
AIDS and other autoimmune diseases could be tackled with a range of new drugs that stop cells recognising certain chemical messages in blood, says Dr Gerry Graham from the Glasgow-based Institute for Cancer Research speaking at the BA Festival of Science today [3 September 2001]. Autoimmune... view more (2001-08-30)

Depression diversity: Brain studies reveal big differences among individuals
Depressed people may have far fewer of the receptors for some of the brain's "feel good" stress-response chemicals than non-depressed people, new University of Michigan Depression Center research shows.   view more (2008-05-08)

Study raises questions about prostate cancer therapies targeting IGF-1
Therapies under development to treat prostate cancer by inhibiting the ability of insulin-like growth factor (IGF-1) to activate its target receptor could have unexpected results especially if a major tumor suppressor gene - p53 - is already compromised, according to new research by investigators... view more (2008-05-01)

High blood pressure, low energy -- a recipe for heart failure
Many people with long-standing high blood pressure develop heart failure. But some don't. Daniel P. Kelly, M.D., and colleagues at Washington University School of Medicine in St. Louis and other institutions are trying to figure out what could explain that difference.   view more (2007-08-10)

Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer
Like tuning a violin to produce strong, elegant notes, researchers at The Wistar Institute have found multiple receptors on the outside of the body's killer immune system cells which they believe can be selectively targeted to keep the cells in superb infection- and disease-fighting condition.   view more (2008-12-01)
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