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What are your odds of surviving into your hundreds?
A genetic factor that protects you against heart disease during middle age could reduce the odds that you'll celebrate your hundredth birthday. Research published in BMC Medical Genetics shows that a genetic trait, which is rarely found in centenarians, is associated with lower cholesterol levels.... view more (2004-02-18)

St. Jude discovery offers new avenues to understanding an aggressive form of leukemia
Researchers at St. Jude Childrenˇ¦s Research Hospital have discovered evidence that a series of genetic mutations work together to initiate most cases of an aggressive and often-fatal form of acute lymphoblastic leukemia (ALL).   view more (2008-04-15)

Enzyme complex thought to promote cancer development can also help prevent it
In a case of basic science detective work, researchers at The University of Texas M. D. Anderson Cancer Center have solved the puzzle of the "inconsistent biomarker" and, in the process, may have discovered an agent that can suppress cancer development.    view more (2005-10-14)

Honey bee genome holds clues to social behavior
By studying the humble honey bee, researchers at the University of Illinois at Urbana-Champaign have come a step closer to understanding the molecular basis of social behavior in humans.   view more (2006-10-24)

Glypican-3 gene function in regulating body size helps inform novel cancer treatments
In a leading study that has implications for the development of novel therapies for a number of breast, lung and ovarian cancers that have lost the expression of a gene called glypican-3 (GPC3), Sunnybrook researchers have discovered how the loss of the GPC3 gene induces overgrowth through certain... view more (2008-05-13)

Both alcoholism and chronic smoking can damage the brain's prefrontal cortex
Alcoholism is commonly associated with chronic smoking, and both alcohol and nicotine are believed to act on the same brain region.   view more (2006-04-24)

Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration
Although repeating sequences of three nucleotides encoding some of the bodies' 20 amino acids are a normal part of protein composition, abnormal expansion of trinucleotide repeats is the known cause of multiple inherited neurodegenerative disorders, including Huntington disease.   view more (2007-11-14)

Interfering RNA silences genes in 'slippery' immune cells
A technical advance in laboratory techniques may provide biology researchers broader access to RNA interference, a process of blocking the activity of targeted genes.   view more (2006-05-09)

Thumbs up -- a tiny ancestral remnant lends developmental edge to humans
Subtle genetic changes that confer an evolutionary advantage upon a species, such as the dexterity characteristic of the human hand, while difficult to detect and even harder to reproduce in a model system, have nevertheless generated keen interest amongst evolutionary biologists.   view more (2008-09-05)

Insight into our sight: A new view on the evolution of the eye lens
The critical component in focusing is the eye lens, and the physical properties that underlie the transparency of the lens, as well as its ability to precisely refract light, arise from the high concentrations of special proteins called crystallins found in lens cells.   view more (2005-09-23)

U of MN researchers link early brain development to adult-onset neurodegenerative disease
Researchers at the University of Minnesota's Institute for Human Genetics have shown for the first time that the severity of an adult neurodegenerative disease is tied to how well the brain developed shortly after birth.   view more (2006-11-17)

A gene for metastasis
Colorectal cancer is one of the most prevalent cancers in the Western world. The tumor starts off as a polyp but then turns into an invasive and violent cancer, which often spreads to the liver.   view more (2007-08-28)

Ewing's sarcoma : Discovery of a "link" in tumor growth
To develop new therapeutic approaches to cancer, it is essential to understand the long and extremely complex process that underlies it, in other words the various stages of cancer development from the initial mutation to the tumor. Having already identified the alteration that leads to Ewing's... view more (2004-09-23)

Bits of 'junk' RNA aid master tumor-suppressor gene
Little-known bits of RNA help master tumor-suppressor gene do its job, U-M cancer researchers find. Three micro RNA genes appear to be key partners of protective gene p53; their loss is linked to common type of lung cancer.   view more (2007-08-24)

Genetic analysis predicts whether liver cancer likely to recur
Researchers are poised to unlock the genetic secrets stored in hundreds of thousands of cancer biopsy samples locked in long-term storage and previously thought to be useless for modern genetic research.   view more (2008-10-16)

Herceptin gives disappointing results in lung cancer trial
Trastuzumab (Herceptin) - a treatment that has increased survival in many breast cancer patients - has failed to live up to hopes that it might also help lung cancer patients.   view more (2004-01-08)

Studies find general mechanism of cellular aging
Three separate studies confirm a gene that suppresses tumor cell growth also plays a key role in aging.   view more (2006-09-07)

Can the tonsils influence oral HIV transmission?
Current research demonstrates that the tonsils may possess the necessary factors to act as a transmission site for the spread of HIV.   view more (2007-07-26)

Umbilical cord gene expression signals premature babies' lung disease risk
Diagnosing a risk of fatal lung disorders may be possible by analysing the umbilical cords of premature babies, according to research published in the online open access journal Genome Biology.   view more (2007-10-04)

Vascular biologists make a significant discovery in neurobiology
Researchers investigating blood vessels at Barts and The London School of Medicine have hit upon a new discovery in neurobiology that could have implications for patients experiencing peripheral nerve disorders.   view more (2007-11-30)

Lungs try to repair damaged elastic fibers
The lungs of patients suffering chronic obstructive pulmonary disease (COPD) attempt to repair damaged elastic fibers, a new finding that contradicts the conventional wisdom on the capabilities of the adult lung.   view more (2006-11-03)

Biologists develop genome-wide map of miRNA-mRNA interactions
Researchers at New York University's Center for Comparative Functional Genomics and the University of California, Berkeley have used computational analyses to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans).   view more (2006-03-09)

Clue found as to why small babies have increased risk of heart disease as adults
The reason why small babies have an increased risk of heart disease as adults may lie in abnormal parental gene transfer, suggests preliminary research in the Journal of Medical Genetics.   view more (2003-08-14)

Gene therapy breakthrough offers hope to patients with inherited high cholesterol levels
New research published in BMC Molecular Biology explains how a new technique for introducing genes into mammalian cells using the virus responsible for warts could be a major step forward in developing gene therapy treatments for people with familial hypercholesterolemia (FH), a genetic disease... view more (2002-05-14)

Gene therapy eradicates pancreatic cancer in preclinical trial
A molecularly engineered therapy selectively embeds a gene in pancreatic cancer that shrinks or eradicates tumors, inhibits metastasis, and prolongs survival with virtually no toxicity.   view more (2007-07-10)
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