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A new molecular marker of gastric cancer
Gastric cancer (GC) is one of the most common malignancies in the world with a high incidence and death rate. TNM staging system is used worldwide to predict prognosis and direct therapeutic decisions of patients with GC. view more (2009-03-31)
Scientists unlock solid tumor treatment genetic secrets
A biochemical mechanism that cells use to cope with hypoxia (lack of oxygen) actually cooperates with a less well-known mechanism that helps increase the expression of those hypoxia-sensitive genes. view more (2005-12-02)
UC San Diego researchers improve accuracy of breast cancer prognoses
One of the many unknowns facing women who are diagnosed with breast cancer is predicting the likelihood that the cancer will spread to other parts of the body - metastasize. view more (2007-10-16)
Targeting the more lethal form of the cancer rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is an aggressive muscle cancer that mostly affects children. The most common forms of RMS are embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS). view more (2009-05-26)
Standard treatment for prostate cancer may encourage spread of disease
A popular prostate cancer treatment called androgen deprivation therapy may encourage prostate cancer cells to produce a protein that makes them more likely to spread throughout the body, a new study by Johns Hopkins researchers suggests. view more (2007-10-01)
Brain DNA 'remodeled' in alcoholism
Reshaping of the DNA scaffolding that supports and controls the expression of genes in the brain may play a major role in the alcohol withdrawal symptoms, particularly anxiety, that make it so difficult for alcoholics to stop using alcohol. view more (2008-04-02)
Study identifies glucose 'sensor' that plays dual role in glucose metabolism and fat synthesis
In the study, glucose is shown to stimulate the activity of the Liver X Receptors (LXR) a and b, The LXRs act as sensors of dietary components, orchestrating the body's response to nutrients such as oxysterols (short-lived derivatives of cholesterol) and controlling gene expression linked to cholesterol and fat metabolism. view more (2006-12-27)
Effects of aging in stem cells
There is little disagreement that the body's maintenance and repair systems deteriorate with age, even as there is plenty of disagreement as to why. view more (2007-07-24)
U-M researchers discover gene switched off in cancer can be turned on
A gene implicated in the development of cancer cells can be switched on using drugs, report researchers from the University of Michigan Comprehensive Cancer Center. view more (2007-06-12)
Mouse model for schizophrenia has genetic on-off switch
Scientists at Johns Hopkins have developed a mouse model for schizophrenia in which a mutated gene linked to schizophrenia can be turned on or off at will. view more (2007-09-11)
Breakthrough in national diseases: Common factor behind myocardial infarction, rheumatism and MS
A common gene variant has been identified as the risk factor behind a number of common diseases by research scientists at Karolinska Institutet and the Centre for Molecular Medicine (CMM), Stockholm, Sweden. Up to a quarter of the population could be affected. view more (2005-04-08)
Genetic vaccine promising against chronic hepatitis C
A potential vaccine candidate against chronic hepatitis C (HCV) infections is presented in a thesis from Karolinska Institutet. The new genetic vaccine can activate immune responses that are needed to clear HCV, a disease that today is difficult to treat effectively. The hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide.... view more... (2004-06-07)
Scientists isolate protein that may be 'boon' to medicine
Scientists at UC Santa Barbara have isolated a unique protein that appears to have a dual function and could lead to a "boon in medicine." view more (2009-08-05)
A common genetic mechanism discovered in nitrogen-fixing plants
Some soil microorganisms are capable of forging associations with plant roots in the form of symbioses. Certain of these relationships play a highly important ecological and agronomic role. view more (2008-03-11)
Neural stem cell gene plays crucial role in eye development
Scientists at the University of North Carolina at Chapel Hill have demonstrated that normal development of the eye requires the right amount of a neural stem cell gene be expressed at the right time and place. view more (2006-05-16)
Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols
Vectors derived from retroviruses are useful tools for long-term gene transfer because they allow stable integration of transgenes and propagation into daughter cells. view more (2009-08-06)
New therapeutic insight into duchenne muscular dystrophy
In the April 1st issue of Genes & Development, Dr. Bruce Spiegelman (Dana Farber Cancer Institute) and colleagues identify a key genetic component of and possible therapeutic target for Duchenne muscular dystrophy. view more (2007-04-02)
Dartmouth researchers discover gene signatures for scleroderma
Distinct genetic profiles can discern different groups of patients with scleroderma, a vexing autoimmune disease in which the body turns against itself, Dartmouth Medical School researchers report. view more (2008-07-16)
Profiling of cancer genes may lead to better and earlier detection
A research team at UT Southwestern Medical Center has for the first time identified several genes whose expression is lost in four of the most common solid human cancers - lung, breast, prostate and colon cancer. view more (2006-12-27)
Nature press release on DiGeorge syndrome paper
[410097] LIFELINES: CATCH 22 (pp97–101) In the 1 March issue of Nature, researchers from Baylor College of Medicine in Texas pinpoint the gene behind one of the most common genetic diseases to affect humans: DiGeorge syndrome. The disease results in a broad spectrum of symptoms, including heart abnormalities, disruption of the immune system... view more... (2001-02-23)
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