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St. Jude gene study reveals basis of anticancer drug resistance in childhood leukemia
The first analysis of the genetic determinants of resistance to the anti-cancer drug methotrexate in childhood acute lymphoblastic leukemia (ALL) could offer a pathway to predicting such resistance and treatments to overcome it, according to a St. Jude Children's Research Hospital study. view more (2008-04-16)
USC researchers identify 'regulatory' genetic sequences that may predict risk for prostate cancer
Researchers at the Keck School of Medicine of the University of Southern California (USC) have identified a novel genetic mechanism that may govern an individual's risk of developing prostate cancer. view more (2009-08-17)
Search for the 'on' switches may reveal genetic role in development and disease
A new resource that identifies regions of the human genome that regulate gene expression may help scientists learn about and develop treatments for a number of human diseases, according to researchers at Duke's Institute for Genome Sciences & Policy (IGSP). view more (2008-01-25)
Epigenetic research uncovers new targets for modification enzymes
Enzymes regulating genetic expression can be just as important as the genome itself, increasing evidence shows. The expanding field of epigenetics focuses on the multiple influences on DNA and surrounding molecules that determine whether genes are turned on or off during development and disease processes. view more (2008-04-28)
Specific Genotype Could Increase Resistance To HIV Drug Therapy (p 383)
A specific mutation of a gene which influences the expression of a glycoprotein transporter protein involved in the body's resistance to drugs and other toxins is detailed in a research letter in this week's issue of THE LANCET. Results of the study suggest that drug therapies used in treating HIV-1 infection (notably protease inhibitors ) may not... view more... (2001-08-01)
Systems biology approach identifies nutrient regulation of biological clock in plants
Using a systems biological analysis of genome-scale data from the model plant Arabidopsis, an international team of researchers identified that the master gene controlling the biological clock is sensitive to nutrient status. view more (2008-03-17)
Short RNAs show a long history
MicroRNAs, the tiny molecules that fine-tune gene expression, were first discovered in 1993. But it turns out they've been around for a billion years. view more (2008-10-02)
Most human-chimp differences due to gene regulation - not genes
The vast differences between humans and chimpanzees are due more to changes in gene regulation than differences in individual genes themselves, researchers from Yale, the University of Chicago, and the Hall Institute in Parkville, Victoria, Australia, argue in the 9 March 2006 issue of the journal Nature. view more (2006-03-09)
A potential targeting gene therapy for developing HCV
Gene therapy has emerged as a novel approach to combat HCV infection in the last few years. view more (2009-07-16)
Jefferson researchers uncover genetic signature that predicts colon cancer
Researchers at Jefferson Medical College in Philadelphia have uncovered a genetic "signature" that accurately identifies colon cancer-a key, they hope, to better understand how the cancer develops. view more (2006-04-05)
Interactive gene 'networks' may predict if leukemia is aggressive or slow-growing
Rather than testing for individual marker genes or proteins, researchers at the University of California, San Diego (UC San Diego) and the Moores UCSD Cancer Center have evidence that groups, or networks, of interactive genes may be more reliable in determining the likelihood that a form of leukemia is fast-moving or slow-growing. view more (2008-12-09)
A potential route for human tumor gene therapy
The type 1 Na+/H+ exchanger (NHE1) is a transmembrane protein found in all eukaryotic cells. One of its functions is to evacuate excessive H+ in the cytoplasm by means of Na+-H+ exchange, resulting in stable intracellular pH value. view more (2008-05-21)
Unique pattern of gene expression can indicate acetaminophen overdose
In a new study, researchers found they could detect toxic levels of acetaminophen in laboratory animals by analyzing gene expression in the blood. view more (2007-11-01)
Chemical genomic screening identifies novel therapeutic strategies for cancer
A sophisticated new chemical genetic screening strategy that serves as a tool for identifying anticancer compounds may significantly enhance the drug discovery process. view more (2006-09-29)
Loss of caspase-8 makes neuroblastoma more aggressive
The caspase-8 gene plays a critical role in suppressing metastasis (spread) of neuroblastoma, and the expression of this gene is frequently absent in cancer cells that are aggressively metastasizing. view more (2006-01-06)
Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs
Researchers at Columbia University Medical Center have illuminated a window into how abnormalities in microRNAs, a family of molecules that regulate expression of numerous genes, may contribute to the behavioral and neuronal deficits associated with schizophrenia and possibly other brain disorders. view more (2008-05-12)
Synthetic Gene Circuit Allows Precise Dosing of Gene Expression
Researchers have crafted a gene circuit that permits precise tuning of a gene's expression in a cell, an advance that should allow for more accurate analysis of the gene's role in normal and abnormal cellular function. view more (2009-03-11)
'Master regulator' of skin formation discovered
Researchers at Oregon State University have found one gene in the human body that appears to be a master regulator for skin development, in research that could help address everything from skin diseases such as eczema or psoriasis to the wrinkling of skin as people age. view more (2009-03-25)
Bacteria control how infectious they become, study finds
The results of a new study suggest that bacteria that cause diseases like bubonic plague and serious gastric illness can turn the genes that make them infectious on or off. view more (2007-04-13)
Il-22 gene delivers the goods and decreases intestinal inflammation
There are two major types of inflammatory bowel disease (IBD), Crohn disease (CD) and ulcerative colitis (UC). view more (2008-01-03)
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