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Mouse model reveals that oncoprotein induces abnormal preleukemic blood cell progenitors
Scientists have developed a novel mouse model for leukemia that reveals critical information about the mechanisms involved in leukemia progression and provides a model system for evaluation of new drugs for treatment of leukemia. view more (2006-01-18)
Impaired gene helps nonsmall-cell lung cancer resist drug
Lung cancer cells with a defective version of a potential tumor suppressor gene are highly resistant to attack by a platinum-based drug commonly used to treat the disease. view more (2006-10-02)
REG1A and its receptor EXTL3 are prognostic markers for colorectal cancer recurrence
Two genes, known as REG1A and EXTL3, are overexpressed in colorectal tumors of patients who are at high risk of recurrence, according to a new study from the Max Delbrueck Center in Berlin, Germany. view more (2006-09-14)
Competing proteins influence strength of tooth enamel
A gene critical to tooth formation expresses a protein that is then cleaved into two proteins with seemingly opposite functions, according to a USC-led team of dental researchers. view more (2005-09-01)
Lamin B locks up Oct-1
A large fraction of the transcription factor Oct-1 is associated with the inner nuclear envelope, but how and why it is retained there was unknown. view more (2009-01-12)
In rare disease, a familiar protein disrupts gene function
An international team of scientists studying a rare genetic disease discovered that a bundle of proteins with the long-established function of keeping chromosomes together also plays an important role in regulating genes in humans. view more (2009-05-27)
Remote control for human growth hormone gene expression
Researchers at the University of Pennsylvania School of Medicine recently discovered a novel mechanism that works over an extensive genomic distance and controls the expression of human growth hormone (hGH) in the pituitary gland. view more (2006-08-14)
Molecule by molecule, new assay shows real-time gene activity
Chemists at Harvard University have developed the first technique providing a real-time, molecule-by-molecule "movie" of protein production in live cells. view more (2006-03-16)
Protein holds back growth of head and neck tumors
A protein associated with the growth of head and neck tumors may be a tumor suppressor that could prevent the spread of cancer when it is expressed above normal levels. view more (2006-02-01)
Model unravels rules that govern how genes are switched on and off
For years, scientists have struggled to decipher the genetic instruction book that details where and when the 20,000 genes in a human cell will be turned on or off. Different genes operate in each cell type at different times, and this careful orchestration is what ultimately distinguishes a brain cell from a liver or skin cell. view more (2008-12-05)
Changes in gene may stunt lung development in children
Mutations in a gene may cause poor lung development in children, making them more vulnerable to diseases such as chronic obstructive pulmonary disease (COPD) later in life, say researchers at the University of Pittsburgh Graduate School of Public Health and the German Research Center for Environmental Health. view more (2009-03-27)
New non-viral vector for gene therapy
A research team from the Universitat Autònoma de Barcelona has designed and built a recombinant protein (synthesised from artificially linked DNA segments) which is capable of releasing genes in specific cells. The new protein is ten times more efficient than the synthetic genetic vehicles in use until now and avoids the risks associated... view more... (2000-06-26)
Study raises questions about prostate cancer therapies targeting IGF-1
Therapies under development to treat prostate cancer by inhibiting the ability of insulin-like growth factor (IGF-1) to activate its target receptor could have unexpected results especially if a major tumor suppressor gene - p53 - is already compromised, according to new research by investigators at Fred Hutchinson Cancer Research Center. view more (2008-05-01)
Altered gene can increase risk of schizophrenia
Rutgers geneticist Linda Brzustowicz and her colleagues have identified a specific DNA change that is likely to increase risk for developing schizophrenia in some people. view more (2009-04-08)
Does every camera tell the whole truth?
Moving images make facial expressions easier to recognise, compared to static pictures; but faces shown in still shots have more intense expressions than those in moving images. view more (1998-12-03)
Scientists identify gene that may contribute to improved rice yield
A team of scientists, including Penn State Distinguished Professor of Biology Hong Ma, has identified a gene in rice that controls the size and weight of rice grains. view more (2008-09-29)
The clustering of Hox genes, involved in the determination of body segments, is not necessary for their proper function
The Hox genes (also known as homeotic genes) play a crucial role in the development of animals, being involved in the determination of segment identity along the body axis. These genes were discovered in the fruit fly Drosophila melanogaster 90 years ago and have been found later in all animals, including humans. The Hox genes are arranged in the... view more... (2005-05-02)
Researchers discover a new genetic cause of Alzheimer's disease
Researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to the University of Antwerp are the first to show that the quantity of amyloid protein in brain cells is a major risk factor for Alzheimer's disease. view more (2006-04-20)
Gene chip data improved therapy in some patients with incurable cancer
Like many oncologists, Eric P. Lester, M.D., was faced with a dilemma: seven patients with advanced, incurable cancer, an arsenal of drugs that may or may not help them, and not enough solid proof about treatment efficacy to guide him. view more (2007-09-20)
Rewrite the textbooks: Transcription is bidirectional
Genes that contain instructions for making proteins make up less than 2% of the human genome. Yet, for unknown reasons, most of our genome is transcribed into RNA. view more (2009-01-26)
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