Gene Mutation Current Events | Gene Mutation News | 11
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Suppression of FOXO1a gene might kill resistant ARMS tumors
The loss of function of a gene called FOXO1a plays an important role in the development of the most common cancer of soft tissues in children, and restoring the function of that gene in cancer cells suppresses that cancer. view more (2005-09-22)
Making Blind Zebrafish See
Scientists in the Conway Institute of Biomolecular & Biomedical Research have restored the sight of blind zebrafish whose eyes failed to develop due to a genetic mutation. The findings, published this week in Developmental Biology, are exciting first steps on a long road to understanding eye diseases in humans. Dr. Breandan Kennedy and his... view more... (2004-07-01)
New evidence of radiation risk in childhood leukaemia
Ionising radiation has long been recognised as a cause of leukaemia in exposed children. But delegates at a conference in London today (Tuesday 7 September) will hear how ground-breaking research is now providing evidence that the children of men exposed to radiation may also be at increased risk of developing leukaemia. view more (2004-09-05)
Therapeutic cloning gets a boost with new research findings
Germ cells, the cells which give rise to a mammal's sperm or eggs, exhibit a five to ten-fold lower rate of spontaneous point mutations than adult somatic cells, which give rise to the body's remaining cell types, tissues and organs. Despite their comparatively higher mutation rates, however, adult somatic cells are used as the donor cells in a... view more... (2009-03-25)
Zinc finger proteins put personalized HIV therapy within reach
Researchers at the University of Pennsylvania School of Medicine and collaborators are using minute, naturally occurring proteins called zinc fingers to engineer T cells to one day treat AIDS in humans. view more (2008-07-01)
Discovery of Genetic Mutation in Florida Beach Mice
Biologists at the University of California, San Diego have found that the main color differences among Florida's mice—which are darker on the mainland, but lighter on the barrier islands to blend in with the white sand dunes—are largely due to a simple genetic mutation. view more (2006-07-10)
Study on origin of mutation that causes Fatal Familiar Insomnia
A PhD thesis at the University of the Basque Country (UPV/EHU) has studied the origin of the mutation that causes Fatal Familiar Insomnia (FFI). In the Autonomous Community of the Basque Country there is a high rate of carriers of this mutation - 50%of all the cases registered in the whole of Spain. view more (2009-01-07)
Genetics and lifestyle interact to increase risk for age-related blindness
The interplay between genetic predisposition and exposure to modifiable risk factors can multiply the risk for age-related macular degeneration. view more (2007-01-09)
U of MN researchers develop mouse model for muscle disease
Researchers from the University of Minnesota have identified the importance of a gene critical to normal muscle function, resulting in a new mouse model for a poorly understood muscle disease in humans. view more (2006-09-06)
UK researchers shed new light on a cause of recurrent miscarriages
Women who carry a particular genetic mutation that predisposes them to blood clots have a significantly higher chance of miscarrying, according to UK researchers in a report (Wednesday 30 January) in Europe's leading reproductive medicine journal Human Reproduction.* The first prospective study into the outcome of untreated pregnancies in a group... view more... (2002-01-26)
Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants
Screening for mutations in a gene that helps the body metabolize a kidney transplant anti-rejection drug may predict which children are at higher risk for side effects, including compromised white blood cell count or organ rejection, according to new research. view more (2009-02-18)
Scientists discover gene mutation responsible for hereditary neuroendocrine tumor
University of Utah researchers and their colleagues have identified the gene that is mutated in a hereditary form of a rare neuroendocrine tumor called paraganglioma (PGL). view more (2009-07-24)
New test can detect both genetic and chromosomal abnormalities in embryos
One-step screening for both genetic and chromosomal abnormalities has come a stage closer as scientists announced that an embryo test they have been developing has successfully screened cells taken from spare embryos that were known to have cystic fibrosis. view more (2009-06-30)
Fragile X retardation syndrome corrected in mice
Researchers working with mice have significantly alleviated a wide range of abnormalities due to fragile X syndrome by altering only a single gene, countering the effects of the fragile X mutation. view more (2007-12-20)
Cystic fibrosis testing -- next steps
Three reports describing advances in cystic fibrosis genetic testing appear in the May 2009 issue of The Journal of Molecular Diagnostics. view more (2009-04-28)
Toxic molecule may cause most common type of muscular dystrophy
Doctors at the University of Virginia Health System have shown for the first time that getting rid of poisonous RNA (ribonucleic acid) in muscle cells can reverse myotonic dystrophy, the most common type of muscular dystrophy in adults. view more (2006-08-25)
Getting down to cancer basics
Researchers have identified a new cancer gene - one that is common to many cancers and affects the most basic regulation of our genes. The new example - a gene on the X chromosome called UTX - is found in 10% of cases of multiple myeloma and 8% of esophageal cancers. view more (2009-03-30)
Hormones increase frequency of inherited form of migraine in women
Familial hemiplegic migraine (FHM) is an inherited form of severe migraine that is accompanied by visual disturbances known as aura. As with other types of migraine, it affects women more frequently than men. view more (2008-12-23)
Cellular traffic backups implicated in skeletal malformations
A defective link in the intracellular protein "transit system" may lie at the heart of some craniofacial defects, new research in zebrafish suggests. view more (2006-09-19)
New view of cancer: 'Epigenetic' changes come before mutations
A Johns Hopkins researcher, with colleagues in Sweden and at the Fred Hutchinson Cancer Research Center, suggests that the traditional view of cancer as a group of diseases with markedly different biological properties arising from a series of alterations within a cell's nuclear DNA may have to give way to a more complicated view. view more (2005-12-22)
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