Gene Mutations Current Events | Gene Mutations News | 11
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Study uncovers mechanism of drug resistance in form of lung cancer
Dana-Farber Cancer Institute researchers and their colleagues have demonstrated that a genetic error so scarce it can't be detected with some standard screening equipment is often responsible for the loss of effectiveness of front-line drugs against non-small cell lung cancer. view more (2006-09-07)
Mutation may cause inherited neuropathy
Mutations in a protein called dynein, required for the proper functioning of sensory nerve cells, can cause defects in mice that may provide crucial clues leading to better treatments for a human nerve disorder known as peripheral neuropathy, which affects about three percent of all those over age 60. view more (2007-12-26)
Advanced-stage ovarian cancer patients with BRCA live longer, may respond better to treatment
Two abstracts underscoring the importance of testing for BRCA1/2 mutations in women with ovarian cancer were presented at this week's Society of Gynecologic Oncologists 39th Annual Meeting on Women's Cancers, by researchers from The University of Texas M. D. Anderson Cancer Center. view more (2008-03-11)
Heart rhythm genes possible factors in SIDS
Nearly 10 percent of sudden infant death syndrome (SIDS) victims have mutations or variations in genes associated with potentially lethal heart rhythms (arrhythmias), according to two newly published studies involving Vanderbilt researchers. view more (2007-01-16)
Theory shows mechanism behind delayed development of antibiotic resistance
Inhibiting the "drug efflux pumps" in bacteria, which function as their defence mechanisms against antibiotics, can mask the effect of mutations that have led to resistance in the form of low-affinity drug binding to target molecules in the cell. view more (2009-05-06)
Yale study offers insight into possible cause of lymphoma
The immune system's powerful cellular mutation and repair processes appear to offer important clues as to how lymphatic cancer develops, Yale School of Medicine researchers report this week in Nature. view more (2008-02-15)
Mayo Clinic Cancer Center finds possible genetic link to pancreatic cancer
Mayo Clinic researchers have found the risk of developing pancreatic cancer at a young age (under 60) to be twice as high for people who carry a mutation of the gene that causes cystic fibrosis, compared to noncarriers. view more (2005-10-21)
Researchers find the mechanism by which cells resist chemotherapy
In his paper, to be published in The EMBO Jorunal, Dr Surrallés describes how proteins of the Fanconi/BRCA pathway recognise the presence of genetic mutations in order to repair them. view more (2007-03-05)
University of Pittsburgh discovers genetic 'shut down' trigger in healthy immune cells
A fundamental genetic mechanism that shuts down an important gene in healthy immune system cells has been discovered that could one day lead to new therapies against infections, leukemia and other cancers. view more (2007-05-10)
Jefferson Scientists Uncover Lethal Gene Mutation Key to Blocking Cholesterol Processing
When Jefferson Medical College researcher Shiu-Ying Ho, Ph.D., and her colleagues first created a mutation that limited the absorption of lipids and cholesterol into the bloodstream in zebrafish, the possibilities seemed endless. view more (2006-04-20)
Landmark studies assess risk of exposure to elevated levels of EMS confirm clear toxicity threshold
New data from studies presented at the XVII International AIDS Conference in Mexico City have provided unprecedented insight into the toxicity of an impurity called ethyl methanesulfonate (EMS). The formation of the EMS impurity is a potential by-product of the manufacturing of mesylate salts, which are contained in over 40 drugs currently... view more... (2008-08-05)
Why does aspirin increase the susceptibility of Helicobacter pylori to antimicrobials?
Resent studies reported that aspirin inhibited the growth of H. pylori in a dose-dependent manner and significantly affected the activity of virulence factors of H. pylori. view more (2009-03-03)
200,000 rice mutants available worldwide for scientific investigation
Scientists across the world are building an extensive repository of genetically modified rice plants in the hope of understanding the function of the approximately 57,000 genes that make up the genome of Oryza sativa. view more (2009-03-05)
'Smothered' genes combine with mutations to yield poor outcome in cancer patients
Johns Hopkins Kimmel Cancer Center researchers have identified a set of genes in breast and colon cancers with a deadly combination of traditional mutations and "smothered" gene activity that may result in poor outcomes for patients. view more (2008-07-16)
Wake up and smell the sweat
Some people are oblivious to the odor in the locker room after a game, while others wrinkle their noses at the slightest whiff of sweat. view more (2007-11-26)
Vaccine to cope with viral diversity in HIV
The ability of HIV-1 to develop high levels of genetic diversity and acquire mutations to escape immune pressures contributes to our difficulties in producing a vaccine. view more (2007-04-27)
Gene thought to assist chemo may help cancer thrive
A gene thought to be essential in helping chemotherapy kill cancer cells, may actually help them thrive. view more (2007-05-16)
Does evolution select for faster evolvers?
It's a mystery why the speed and complexity of evolution appear to increase with time. For example, the fossil record indicates that single-celled life first appeared about 3.5 billion years ago, and it then took about 2.5 billion more years for multi-cellular life to evolve. view more (2007-01-30)
Effectiveness of mouse breeds that mimic Alzheimer's disease symptoms questioned
Scientists have shown that recently developed mouse breeds that mimic the symptoms of Alzheimer's disease (AD) may not be as effective as previously assumed. view more (2007-08-17)
More gene mutations linked to autism risk
More pieces in the complex autism inheritance puzzle are emerging in the latest study from a research team including geneticists from The Children's Hospital of Philadelphia, the University of Pennsylvania School of Medicine and several collaborating institutions. view more (2009-06-26)
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