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Model unravels rules that govern how genes are switched on and off
For years, scientists have struggled to decipher the genetic instruction book that details where and when the 20,000 genes in a human cell will be turned on or off. Different genes operate in each cell type at different times, and this careful orchestration is what ultimately distinguishes a brain cell from a liver or skin cell. view more (2008-12-05)
MicroRNAs play a big part in gene regulation-and evolution
egulating when and where certain proteins are made is crucial to the normal functioning of living things. To make proteins, information from DNA is transcribed into RNA molecules and then translated into the amino acids building blocks of proteins. view more (2005-06-24)
First trial of gene therapy for advanced heart failure shows promising results
Phase I results of the first clinical trial of gene therapy for patients with advanced heart failure show the approach to be promising, with improvements in several measures of the condition's severity. view more (2008-11-11)
Study finds genomic changes in the brains of people who commit suicide
Are genes destiny? Alternatively, are we simply the products of our environment? There is a growing sense that neither of these two possibilities fully captures the essence of the risk for psychiatric disorders. view more (2008-10-23)
URI scientists reveal mechanism that regulates cancer-causing gene
Two University of Rhode Island scientists have revealed how a cancer causing protein is regulated by reactive oxygen species (ROS) -- a type of stress signal. Their findings provide new insight into how this protein normally behaves in human cells and may help in the design of drugs targeting specific cancers. view more (2009-03-27)
The most important candidate genes for pancreatic stone formation
Stone formation is an important feature of chronic pancreatitis, especially tropical calcific pancreatitis (TCP), where the stones are large in size, highly irregular in shape and cause enormous tissue destruction. view more (2007-11-14)
New gene linked to bipolar disorder
A new gene linked to both depression and bipolar disorder has been identified by UCL (University College London) and Danish researchers. view more (2006-10-04)
A potential targeting gene therapy for developing HCV
Gene therapy has emerged as a novel approach to combat HCV infection in the last few years. view more (2009-07-16)
Researchers see evidence of memory in the songbird brain
When a zebra finch hears a new song from a member of its own species, the experience changes gene expression in its brain in unexpected ways, researchers report. view more (2009-06-29)
Molecule discovered to be key to pain sensitivity
Sensitivity to pain and the risk of developing chronic pain appear to be influenced by levels of a molecule known to be required for the production of major neurotransmitters. view more (2006-10-23)
Jefferson researchers uncover new way nature turns genes on and off
Peering deep within the cells of fruit flies, developmental biologists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia may have discovered a new way that genes are turned on and off during development. view more (2006-12-28)
Systems biology approach identifies nutrient regulation of biological clock in plants
Using a systems biological analysis of genome-scale data from the model plant Arabidopsis, an international team of researchers identified that the master gene controlling the biological clock is sensitive to nutrient status. view more (2008-03-17)
First Parkinson's Gene Therapy Patient Passes One Year
The first ever patient to have undergone gene therapy for Parkinson's appears to have come through phase I without a hitch, suggesting that the therapy is safe and effective, reports Marina Murphy in Chemistry & Industry. view more (2004-09-02)
CSHL scientists discover new details of a gene-regulatory network governing metabolism
Metabolism is a central feature of life - a myriad of biochemical processes that, together, enable organisms to nourish and sustain themselves. Scientists at Cold Spring Harbor Laboratory (CSHL) are in the forefront of efforts to demonstrate how the regulation of genes governs fundamental life processes, including metabolism. view more (2008-02-25)
Overeating and obesity triggered by lack of BDNF
According to the Centers for Disease Control and Prevention, close to one-third of the population in the United States is obese and another third is overweight. view more (2007-12-28)
Dardarina, the Basque gene for Parkinson's
Research began when doctors discovered that various members of the same family had Parkinson's. There are many kinds of Parkinson's and some are hereditary. Now, a group of scientists have identified the gene which produces the hereditary Park8 variant of Parkinson's in four Basque families and another in the UK. The gene is called dardarina; a... view more... (2004-11-04)
Polymers are promising tools for gene therapy
New methods are being developed to cure illnesses with the aid of gene therapy. Polymer technology provides new and versatile possibilities for administering gene doses. "Polymers are used to pack the gene to be transferred into particles of the size of a ten thousandth of a millimetre. These polymers effectively transport the transferable... view more... (2002-04-24)
LSUSHC researchers find potential new target for hypertension treatment
Huijing Xia, PhD, a postdoctoral research associate in the lab of Eric Lazartigues, PhD, Assistant Professor of Pharmacology at LSU Health Sciences Center New Orleans, is the lead author on a paper reporting that a recently identified enzyme in the brain plays a critically important role in the central regulation of blood pressure. view more (2009-02-02)
Bats add their voice to the FOXP2 story
When it comes to the FOXP2 gene, humans have had most to shout about. Discoveries that mutations in this gene lead to speech defects and that the gene underwent changes around the time language evolved both implicate FOXP2 in the evolution of human language. view more (2007-09-19)
How Rett Syndrome mutation targets the brain
Researchers have pinpointed why mutations that cause Rett Syndrome (RTT)-among the leading causes of mental retardation in females-specifically target the brain rather than other body tissues. view more (2006-10-19)
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