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Abnormal overexpression of p53 is a predictive molecular biomarker
A common laboratory test that predicted poor outcome from traditional radiation and chemotherapy treatment for head and neck cancers now has been found to predict a good prognosis with treatment of p53 tumor suppressor gene therapy-making it potentially the first predictive biomarker test for a gene-based drug. view more (2006-09-15)
U of Minnesota researchers find master gene behind blood vessel development
In a first of its kind discovery, University of Minnesota researchers have identified the "master gene" behind blood vessel development. Better understanding of how this gene operates in the early stages of development may help researchers find better treatments for heart disease and cancer. view more (2009-02-05)
Chronic fatigue syndrome impairs a person's slow wave activity during sleep
Chronic fatigue syndrome (CFS) has been associated with altered amounts of slow wave sleep, which could reflect reduced electroencephalograph (EEG) activity and impaired sleep regulation. view more (2007-05-01)
Supplements even confuse athletes
As winter approaches many of us reach for over-the-counter vitamins and herbal remedies, such as Vitamin C and Echinacea, in a bid to ward off illnesses and improve health. But the vast array of supplements available and lack of industry regulation make it difficult for the average person to make an informed choice about taking supplements. view more (2007-11-08)
The Protein Srebp2 Drives Cholesterol Formation in Prion-Infected Neuronal Cells Which May Promote Prion-Dependent Diseases
The regulating protein Srebp2 drives cholesterol formation, which prions need for their propagation, in prion-infected neuronal cells. view more (2009-11-19)
Masterminding muscle development
Dr. Lizi Wu (Dana Farber Cancer Institute) and colleagues report on a critical role for one of the three mammalian mastermind genes (Maml1) in myogenesis - assigning that first biological function to the mammalian MAML Notch co-activators. view more (2006-02-28)
Honey bee genome holds clues to social behavior
By studying the humble honey bee, researchers at the University of Illinois at Urbana-Champaign have come a step closer to understanding the molecular basis of social behavior in humans. view more (2006-10-24)
Ethical considerations can become an integral part of the European regulation of biotechnology.
A new report, published as part of a project sponsored by the Danish action plan for bio-technology and ethics, concludes that the European Union ought to include ethical principles in the regulation of biotechnology. Until now the regulation of biotechnology in the European Union has primarily been con-cerned with trade, security and... view more... (2002-10-08)
Key brain regulatory gene shows evolution in humans
Researchers have discovered the first brain regulatory gene that shows clear evidence of evolution from lower primates to humans. view more (2005-12-13)
Researchers first to map gene that regulates adult stem cell growth
A new discovery in stem cell research may mean big things for cancer patients in the future. Gary Van Zant, Ph.D., and a research team at the University of Kentucky published their findings today in Nature Genetics, an international scientific journal. view more (2007-01-15)
Would you like gene chips with your salad ?
The first public release of plant gene chip information is being launched at the Society for Experimental Biology conference in Swansea on Friday 12th April. Scientists from the Nottingham Arabidopsis Stock Centre (NASC), part of a multi-million pound resource network, will announce a newly accessible plant gene chip database which is available... view more... (2002-04-11)
Mouse study reveals human X-SCID gene therapy poses substantial cancer risk
New animal studies conducted at the Salk Institute for Biological Studies show that the only human gene therapy treatment to date considered to be largely successful, is, in fact, riskier than realized. view more (2006-04-27)
Fruit flies unlock Methuselah's secrets
New research published in Genome Biology investigates genes that increase the life span of fruit flies in an effort to gain a greater understanding of the ageing process. The researchers from the University of Southern California and Harvard Medical School screened 10,000 fruit fly populations that were mutated. Their results revealed that six... view more... (2003-01-30)
Sleepy fruit flies provide clues to learning and memory
Researchers at the University of Pennsylvania School of Medicine have discovered that a brain region previously known for its role in learning and memory also serves as the location of sleep regulation in fruit flies. view more (2006-06-16)
Researchers identify new risk factor gene for rheumatoid arthritis
Scientists at The Feinstein Institute for Medical Research and a team of collaborators from across the country have identified a new risk factor gene for rheumatoid arthritis. view more (2009-06-10)
Il-22 gene delivers the goods and decreases intestinal inflammation
There are two major types of inflammatory bowel disease (IBD), Crohn disease (CD) and ulcerative colitis (UC). view more (2008-01-03)
First significant genetic finding in severe PMS, or PMDD
The first significant genetic finding in premenstrual dysphoric disorder (PMDD) has now been reported. PMDD is a very severe form of the more commonly known premenstrual syndrome, or PMS. view more (2007-10-03)
Van Andel Institute Study Rules Out Transcriptional Coactivators as Useful Herpes Antiviral Drug Targets
Researchers at Van Andel Research Institute (VARI) have determined that the herpes simplex virus type 1 (HSV-1) does not require transcriptional coactivators for viral gene expression early in the infection process. The finding is significant in determining that, in contradiction to earlier models, chemical inhibitors of these cellular proteins... view more... (2009-03-26)
Killing the messenger RNA — But which one?
Tiny molecules called microRNAs, only 19 to 21 nucleotides in length, are able to effectively silence sometimes large sets of genes. They do this by specifically binding to and neutralizing another form of RNA called messenger RNA, responsible for conveying the information from genes to the cellular machinery that uses that information to create... view more... (2007-02-23)
Calcium may be the key to understanding Alzheimer's disease
Researchers at the University of Pennsylvania School of Medicine have shown that mutations in two proteins associated with familial Alzheimer's disease disrupt the flow of calcium ions within neurons. The two proteins, called PS1 and PS2 (presenilin 1 and 2), interact with a calcium release channel in an intracellular cell compartment. view more (2008-07-21)
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