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Gene Silencing Current Events | Gene Silencing News
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Silence please
Researchers at Cambridge University have been studying the process of gene silencing in transgenic plants, and have cloned a genetic modifier that could reduce transgene instability. Dr Ian Furner will be presenting the results of the study at the Society for Experimental Biology conference on Monday 8 April. view more (2002-04-04)
Linking DNA and histone methylation
In the May 15th issue of G&D, Dr. Michael Carey (UCLA's Jonsson Comprehensive Cancer Center) and colleagues lend new insight into the mechanism of epigenetic silencing of euchromatic genes. view more (2007-04-30)
Non-coding RNAs help silence the mammalian transcription
Dr. Shirley Tilghman and colleagues (Princeton University) lend new insight into the mechanism of genomic imprinting, demonstrating a necessary role for a non-coding RNA transcript in the silencing of an imprinted gene cluster in mice. view more (2006-05-15)
Silencing the cause of mad cow disease
BSE (more commonly known as mad cow disease) and CJD, which is a related disease in humans that can occur spontaneously, be inherited, or be acquired (in some cases probably from cows with BSE), are fatal neurodegenerative diseases. view more (2006-12-04)
Norwich scientist receives prestigious international science prize
"I am very pleased that the work of my group has been recognised by this award", said Professor David Baulcombe. "I am also delighted to see that research into plants has been acknowledged. It is often forgotten that plants are excellent models for many types of genetic and biochemical research. Beijerincks discovery of viruses in... view more... (2004-10-28)
A new gene silencing platform -- silence is golden
A team of researchers led by Rutgers' Samuel Gunderson has developed a novel gene silencing platform with very significant improvements over existing RNAi approaches. view more (2009-02-09)
Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome
Researchers from Uppsala University have discovered a mechanism that silences several genes in a chromosome domain. The findings, published in today's on-line issue of Molecular Cell, have implications in understanding the human disorder Beckwith-Wiedemann syndrome. view more (2008-10-27)
Bread mold may hold secret to eliminating disease-causing genes
When most people discover mold on their bread, they immediately throw it out. Others see a world of possibilities in the tiny fungus. A University of Missouri scientist, along with a collaborative research team, has examined a new mechanism in the reproductive cycle of a certain species of mold. view more (2008-05-09)
Protein protects anti-cancer gene from chemical shutdown
A protein that is largely absent in one type of skin cancer protects an important gene in a cell's defense against harmful mutations from being silenced. view more (2007-07-20)
Gene shut-down may offer early warning of chronic leukemia
A new study shows that certain genes are turned off early, before clinical signs of the disease appear, in the development of chronic leukemia. view more (2009-08-06)
An effective target of biological therapy for hepatocellular carcinoma
It has been shown that constitutively activated STAT3 is detected in many HCC cell lines and tissues. This suggests that STAT3 is a promising molecular target for HCC gene therapy. view more (2009-06-15)
Plants display 'molecular amnesia'
Plant researchers from McGill University and the University of California, Berkeley, have announced a major breakthrough in a developmental process called epigenetics. They have demonstrated for the first time the reversal of what is called epigenetic silencing in plants. view more (2008-12-03)
In lung cancer, silencing one crucial gene disrupts normal functioning of genome
While examining patterns of DNA modification in lung cancer, a team of international researchers has discovered what they say is a surprising new mechanism. view more (2009-01-05)
New gene silencing pathway found in plants
Biologists at Washington University in St. Louis have made major headway in explaining a mechanism by which plant cells silence potentially harmful genes. view more (2008-11-18)
Turn-ons and turn-offs for neurons
Our brain consists of billions of nerve cells enabling to learn, remember and reason. Every time we think and experience, touch, smell or fear, millions of neurons in our brain becomes active. view more (2007-06-20)
Silence the gene, save the cell: RNA interference as promising therapy for ALS
Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland have used RNA interference in transgenic mice to silence a mutated gene that causes inherited cases of amytrophic lateral sclerosis (ALS), substantially delaying both the onset and the progression rate of the fatal motor neuron disease. Their results... view more... (2005-03-09)
Less can be more, for plant breeders too
Imagine you are a rice breeder and one day within a large field you discover a plant that has just the characteristics you have been looking for. You happily take your special plant to the laboratory where you find out that the spontaneous, beneficial event was due to inactivation of a single gene. view more (2008-03-20)
New method for gene expression experiments akin to watercolor painting in water
Like oil and water, two water-based liquids can mingle without mixing in a new University of Michigan technology developed for biological experiments. view more (2009-08-19)
Targeted nanoparticles incorporating siRNA offer promise for cancer treatment
The use of targeted nanoparticles offers promising techniques for cancer treatment. Researchers in the laboratory of Mark E. Davis at the California Institute of Technology have been using small interfering RNA (siRNA), sometimes known as silencing RNA, to "silence" specific genes that are implicated in certain malignancies. view more (2007-05-21)
Molecular steps involved in the creation of gene-silencing MicroRNAs identified
First discovered only a few brief years ago, microRNAs are small, remarkably powerful molecules that appear to play a pivotal role in gene silencing, one of the body's main strategies for regulating its genome. A scant 22 nucleotides in length, miRNAs appear to work by binding to and somehow interfering with messenger RNA, itself responsible for... view more... (2005-06-23)
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