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Moving gene therapy forward with mobile DNA
Gene therapy is the introduction of genetic material into a patient's cells resulting in a cure or a therapeutic effect. In recent years, it has been shown that gene therapy is a promising technology to treat or even cure several fatal diseases for which there is no attractive alternative therapy. view more (2009-05-04)
Getting more from whole-transcript microarrays
The widely-used Affymetrix Whole-Transcript Gene 1.0 ST (sense target) microarray platform, normally used to assay gene expression, can also be utilized to interrogate exon-specific splicing. view more (2009-05-22)
Early-stage gene transcription creates access to DNA
A gene contained in laboratory yeast has helped an international team of researchers uncover new findings about the process by which protein molecules bind to control sequences in genes in order to initiate gene expression, according to findings reported in the journal Nature. view more (2008-10-07)
Longevity gene also protects memory, cognitive function
A gene variation that helps people live into their 90s and beyond also protects their memories and ability to think and learn new information, according to a study published in the December 26, 2006, issue of Neurology, the scientific journal of the American Academy of Neurology. view more (2006-12-26)
UVa researchers restore genes in human inner ear cells
Researchers at the University of Virginia Health System have discovered a way to transfer genes, which they hope will restore hearing, into diseased tissue of the human inner ear. view more (2007-06-14)
"Suicide gene" injection shrinks cancer growth
Injectable "suicide gene" therapy may be a highly effective way of preventing colon cancer from spreading (metastasising), finds research in Gut. Human colon cancer carries a high risk of death because it is often not found in the early stages and readily spreads to the liver, but also the lungs and throughout the abdominal cavity (peritoneum). view more (2002-02-08)
A new kind of mutation could explain numerous phenotypic variations in various species
The authors describe the discovery of a novel class of mutations that disrupt the function of a gene and thereby cause a specific phenotype. The mutation created the appearance of an "illegitimate" microRNA (miRNA) recognition site in a gene that did not have it in its normal form. view more (2006-06-06)
Fly with brain tumor may shed light on cancer causing genes
A study showing how the expression of genes changes when the brain tissue of fruit flies becomes cancerous is published this week in BMC Genomics. As the function of many of these genes is conserved across evolution, the researchers expect their results will help us to understand why human brain tumors develop. The causes of brain tumor... view more... (2004-04-14)
No test needed for hand-foot genital syndrome in women without HOXA13 gene mutation
Hugh S. Taylor, M.D., professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale, and colleagues have found that women without mutations of the HOXA13 gene do not need to be subjected to x-rays and other tests for a rare condition called hand-foot genital syndrome. view more (2009-10-20)
Different but equal: Settling the dosage compensation debate
Independent research papers from Dr. Peter Becker (Munich, Germany) and Dr. Mitzi Kuroda (Boston, MA) in the October 1 issue of Genes & Development delineate the mechanism of X-chromosome dosage compensation in Drosophila. view more (2005-10-03)
MRC Research Offers Hope of Treatment for People with Duchenne Muscular Dystrophy
A new approach which effectively patches over genetic defects offers hope of treatment to people with the terminal illness, Duchenne muscular dystrophy. This is the conclusion of research led by Dr Qi Long Lu and Professor Terence Partridge at the Medical Research Council's Clinical Sciences Centre. Most cases of Duchenne muscular dystrophy are... view more... (2003-07-04)
Did the gene for ADHD help our nomadic ancestors?
An ADHD-associated version of the human gene DRD4 is linked to better health among nomadic tribesmen, but may cause malnourishment in their settled cousins, according to new research by a team directed by an anthropologist at the University of Wisconsin-Milwaukee (UWM). view more (2008-06-17)
Common cold virus efficiently delivers corrected gene to cystic fibrosis cells
Scientists have worked for 20 years to perfect gene therapy for the treatment of cystic fibrosis, which causes the body to produce dehydrated, thicker-than-normal mucus that clogs the lungs and leads to life threatening infections. view more (2009-07-21)
Gene therapy slows progression of fatal neurodegenerative disease in children
Gene therapy to replace the faulty CLN2 gene, which causes a neurodegenerative disease that is fatal by age 8-12 years, was able to slow significantly the rate of neurologic decline in treated children. view more (2008-05-14)
Junk DNA may prove invaluable in quest for gene therapies
Scientists have identified how a protein enables sections of so-called junk DNA to be cut and pasted within genetic code - a finding which could speed development of gene therapies. view more (2009-09-22)
Researchers develop new, more-sensitive assay for detecting DNA methylation in colon cancer
A study published in this week's online issue of Nature Biotechnology, demonstrates a unique and highly sensitive method for detecting methylation-associated cancers. view more (2009-08-17)
Core needle biopsy gives an accurate picture of gene expression in whole tumor
The gene expression profile detected in the core needle biopsy of a breast tumour is representative of gene expression in the whole tumour. view more (2006-08-21)
Does missing gene point to nocturnal existence for early mammals?
A gene that makes cells in the eye receptive to light is missing in humans, researchers have discovered. view more (2006-10-13)
Cranberries can treat herpes
Alpine cranberries have significant biological activity that can help to combat herpes virus type II (HSV-2) infection, one of the most common viral infections in humans, writes Emma Dorey in Chemistry & Industry. view more (2004-10-15)
The genetic basis for autoimmunity discovered
Researchers from the Basque University have discovered the relationship between E2F2 gene and autoimmunity. The Science Faculty team, leaded by Ana Zubiaga has published the results of its researches in the fifteenth issue of the Immunity magazine. The team began analysing E2F2 gene and its family. This gene family is responsible for the cell... view more... (2002-03-01)
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