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UC Davis researchers shed new light on how chemotherapy-induced leukemia develops
Topoisomerase II inhibitors are among the most successful chemotherapy drugs used to treat human cancer. view more (2005-11-16)
Gene therapy protocol at UCSD activates immune system in patients with leukemia
A research team at the Moores Cancer Center at University of California, San Diego (UCSD) reports that patients with chronic lymphocytic leukemia (CLL) who were treated with a gene therapy protocol began making antibodies that reacted against their own leukemia cells. view more (2008-02-12)
Mouse study reveals human X-SCID gene therapy poses substantial cancer risk
New animal studies conducted at the Salk Institute for Biological Studies show that the only human gene therapy treatment to date considered to be largely successful, is, in fact, riskier than realized. view more (2006-04-27)
Study finds BRAF mutations in colorectal cancer cause resistance to anti-EGFR therapy
European researchers have found that metastatic colorectal cancer patients with a mutation in the BRAF gene do not respond to anti-EGFR therapy with cetuximab and panitumumab. view more (2008-10-23)
Study identifies biomarker that safely monitors tumor response to new brain cancer treatment
A specific biomarker, a protein released by dying tumor cells, has been identified as an effective tool in an animal model to gauge the response to a novel gene therapy treatment for glioblastoma mulitforme. view more (2009-07-01)
Pioneers in field of functional genomics work toward gene therapy for vision defects
"Primates and humans have three photoreceptors and can only see four basic colors, red, green, blue and yellow," says Jay Neitz, Ph.D. "Birds, fish and reptiles have four photoreceptors, allowing them to see things we cannot. They must see an entire dimension of color, including ultraviolet, infrared and all the combinations... view more... (2006-12-12)
Abnormal overexpression of p53 is a predictive molecular biomarker
A common laboratory test that predicted poor outcome from traditional radiation and chemotherapy treatment for head and neck cancers now has been found to predict a good prognosis with treatment of p53 tumor suppressor gene therapy-making it potentially the first predictive biomarker test for a gene-based drug. view more (2006-09-15)
In blood vessel stents, innovative materials allow better control, delivery of gene therapy
Before gene therapy becomes practical for treating human diseases, researchers must master the details of safe and effective delivery. view more (2008-04-16)
Discovery in 'Bubble Boy' disease gene therapy
Scientists at St. Jude Children's Research Hospital have developed a mouse model of a severe disease of the immune system that helps explain why gene therapy used to treat children with this disease at an institution in Europe caused some of them to develop leukemia. view more (2006-08-02)
Researchers discover mechanism of insulin production that can lead to better treatment for diabetes
How a specific gene within the pancreas affects secretion of insulin has been discovered by researchers from the Hebrew University of Jerusalem, in collaboration with Japanese and American universities. view more (2009-11-13)
UF makes gene therapy advance in severe genetic disorder
A dog born with a deadly disease that prevents the body from using stored sugar has survived 20 months and is still healthy after receiving gene therapy at the University of Florida - putting scientists a step closer to finding a cure for the disorder in children. view more (2009-05-29)
Microarray technology could help predict patient response to adjuvant therapy for breast cancer
Microarray technology could be used to tailor therapy according to the individual, and prevent breast cancer patients from having to undergo painful unsuccessful therapies. view more (2005-10-03)
Ancient DNA helps UF researchers unearth potential hemophilia therapy
A cut can be life-threatening for people with hemophilia, whose bodies don't produce enough of a protein that prevents prolonged bleeding. view more (2006-02-28)
Gene Therapy Studies Show First Successes
Within the third international conference of the "Euregenethy" held at the Paul-Ehrlich-Institut in Langen near Frankfurt on Thursday, 15th April, and Friday, 16th April 2004, international experts reported on success and side effects of clinical gene therapy. Euregenethy, coordinated by Odile Cohen-Haguenauer from the "Ecole... view more... (2004-04-16)
HIV inserts into human genome using a DNA-associated protein
A human DNA-associated protein called LEDGF is the first such molecule found to control the location of HIV integration in human cells. view more (2005-11-28)
Gene patenting -- steep cost for health care and patients
The drug trastuzumab (Herceptin) is used to treat HER2-positive breast cancer (a type of breast cancer that overexpresses the HER2 gene and accounts for about 25% of all breast cancers). view more (2007-05-08)
New target for cancer therapy identified
A new target for cancer therapy has been identified by Monash University scientists investigating the cell signalling pathways that turn on a gene involved in cancer development. view more (2006-09-22)
Gene variants linked with increased risk of death among heart patients treated with beta-blockers
Patients with certain gene variants who were prescribed beta-blocker drugs after acute coronary syndrome (ACS) had an increased risk of death over the next three years, according to a study in the September 28 issue of JAMA. view more (2005-09-28)
MIT works toward safer gene therapy
In work that could lead to safe and effective techniques for gene therapy, MIT researchers have found a way to fine-tune the ability of biodegradable polymers to deliver genes. view more (2007-09-10)
Skin flaps deliver cancer-fighting therapy, ASPS study reveals
Using gene therapy, plastic surgeons have delivered cancer fighting proteins through skin flaps placed on cancerous tumors on rats with a 79 percent reduction in tumor volume. view more (2008-05-09)
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