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Study shows liver an excellent target for cancer gene therapy using viral vectors
A featured paper in the February 14 issue of Nature Cancer Gene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differences between cancerous and normal liver cells. view more (2007-02-15)
Previous claims of siRNA therapeutic effects called into question by report in human gene therapy
The many recent reports documenting the therapeutic efficacy of short interfering RNAs (siRNAs) in animal models of human disease may actually be describing non-specific therapeutic effects related to the ability of siRNA to activate an immune response, according to a paper in the September 2008 issue (Volume 19, Number 9) of Human Gene Therapy, a... view more... (2008-09-03)
UF, French scientists seek test to detect gene doping in athletes
Gene doping has the potential to spawn athletes capable of out-running, out-jumping and out-cycling the strongest of champions. But research under way at the University of Florida could help level the playing field by detecting the first cases of gene doping in professional athletes before the practice enters the mainstream. view more (2007-08-07)
Impaired gene helps nonsmall-cell lung cancer resist drug
Lung cancer cells with a defective version of a potential tumor suppressor gene are highly resistant to attack by a platinum-based drug commonly used to treat the disease. view more (2006-10-02)
Safety study indicates gene therapy for blindness improves vision
All three people who received gene therapy at the University of Florida to treat a rare, incurable form of blindness have regained some of their vision, according to a paper published online today in Human Gene Therapy. view more (2008-09-09)
Magnetic nanoparticles navigate therapeutic genes through the body
Health professionals send genes and healthy cells on their way through the bloodstream so that they can, for example, repair tissue damage to arteries. view more (2009-03-05)
Gene therapy for hereditary lung disease advances
An experimental gene therapy to combat alpha-1 antitrypsin deficiency, a common hereditary disorder that causes lung and liver disease, has caused no harmful effects in patients and shows signs of being effective, University of Florida researchers say. view more (2006-11-22)
New therapy substitutes missing protein in those with muscular dystrophy
Researchers at the University of Minnesota Medical School have discovered a new therapy that shows potential to treat people with Duchenne muscular dystrophy, a fatal disease and the most common form of muscular dystrophy in children. view more (2009-05-27)
Why don't brain tumors respond to medication?
Malignant brain tumors often fail to respond to promising new medication. Researchers in Heidelberg have discovered a mechanism and a tumor marker for the development of this resistance. view more (2009-09-01)
UF researchers develop improved gene therapy agent
Replacing one amino acid on the surface of a virus that shepherds corrective genes into cells could be the breakthrough scientists have needed to make gene therapy a more viable option for treating genetic diseases such as hemophilia, University of Florida researchers say. view more (2008-05-20)
Automatic slicing system: Ex-vivo culture normal and cancerous pancreatic tissue
Pancreatic cancer is a devastating disease with a very poor prognosis. This warrants the development of novel therapies including gene therapy. Several of these treatments were found to be effective in pre-clinical (animal) models. However, in the subsequent clinical studies in patients the results were disappointing. view more (2009-03-24)
Targeting treatment
The effectiveness of many potentially powerful treatments including drug therapy, gene therapy and cancer chemotherapy is often reduced because it can be difficult to target the treatment exactly where it will be most effective. One of the problems is that it is frequently difficult for drugs, as well as DNA and other biological molecules, to pass... view more... (2002-03-26)
Standard treatment for prostate cancer may encourage spread of disease
A popular prostate cancer treatment called androgen deprivation therapy may encourage prostate cancer cells to produce a protein that makes them more likely to spread throughout the body, a new study by Johns Hopkins researchers suggests. view more (2007-10-01)
Molecular Therapy for Spinal Muscular Atrophy Closer to Clinical Use
Spinal muscular atrophy, a neurodegenerative disorder that causes the weakening of muscles, is the leading cause of infant death and occurs in 1 in 6,000 live births. view more (2008-12-17)
Gene mutation improves leukemia drug's effect
Gene mutations that make cells cancerous can sometimes also make them more sensitive to chemotherapy. A new study led by cancer researchers at Ohio State University shows that a mutation present in some cases of acute leukemia makes the disease more susceptible to high doses of a particular anticancer drug. view more (2008-06-18)
Mayo Clinic researchers invent 'hitchhiking' viruses as cancer drug delivery system
A Mayo Clinic research team has devised a new virus-based gene therapy delivery system to help fight cancer. Researchers say their findings will help overcome hurdles that have hindered gene therapy cancer treatments. view more (2005-09-19)
New paradigm for cell-specific gene delivery
Researchers from Northwestern University and Texas A & M University have discovered a new way to limit gene transfer and expression to specific tissues in animals. view more (2008-06-23)
Inappropriate sepsis therapy leads to fivefold reduction in survival
Patients experiencing septic shock who receive inappropriate therapy may have a fivefold reduction in survival, shows a new study. view more (2009-11-05)
Imitating monkey's 'jumping genes' could lead to new treatments for HIV
UCL (University College London) scientists have taken a significant step in understanding how retroviruses such as HIV can move between species and the biological mechanisms behind the 'jumping genes' which make some monkeys immune. They will now use this knowledge to develop a gene therapy treatment for HIV/AIDS in humans. view more (2008-02-19)
Jumping gene could provide non-viral alternative for gene therapy
A jumping gene first identified in a cabbage-eating moth may one day provide a safer, target-specific alternative to viruses for gene therapy. view more (2006-09-26)
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