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New genes at work in patients with hereditary lung disease
University of Florida researchers have safely given new, functional genes to patients with a hereditary defect that can lead to fatal lung and liver diseases, according to clinical trial findings slated to appear this week in the online early edition of the Proceedings of the National Academy of Sciences. view more (2009-08-11)
No-entry zones for AIDS virus
The AIDS virus inserts its genetic material into the genome of the infected cell. Scientists of the German Cancer Research Center have now shown for the first time that the virus almost entirely spares particular sites in the human genetic material in this process. This finding may be useful for developing new, specific AIDS drugs. view more (2009-11-13)
Dual gene therapy suppresses lung cancer in preclinical test
Combination gene therapy delivered in lipid-based nanoparticles drastically reduces the number and size of human non-small cell lung cancer tumors in mice. view more (2007-01-15)
Gene therapy corrects sickle cell disease in laboratory study
Using a harmless virus to insert a corrective gene into mouse blood cells, scientists at St. Jude Children's Research Hospital have alleviated sickle cell disease pathology. view more (2008-12-04)
Ethnic differences in response to HIV medicines
Researchers from the University of Massachusetts and the University of Pennsylvania have shown that race/ethnicity is a predictor of plasma lipids in patients with HIV-1 on HAART (highly active antiretroviral therapy). view more (2006-01-24)
Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer
A cancer-suppressing gene has been successfully delivered into the tumors of stage 4 lung cancer patients via an intravenously administered lipid nanoparticle in a phase I clinical trial at The University of Texas M. D. Anderson Cancer Center. view more (2007-04-18)
New approach to gene therapy may shrink brain tumors, prevent their spread
Massachusetts General Hospital (MGH) researchers are investigating a new approach to gene therapy for brain tumors - delivering a cancer-fighting gene to normal brain tissue around the tumor to keep it from spreading. view more (2008-09-26)
New gene silencing therapy for cervical cancer
Researchers at The University of Queensland's (UQ) Centre for Immunology and Cancer Research (CICR), based at the Princess Alexandra Hospital, have pioneered a new approach for the treatment of cervical cancer. view more (2005-11-17)
Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
Virginia Commonwealth University researchers studying hemoglobin genes, mutations of which play a role in genetic blood disorders like sickle cell anemia and beta-thalassemia, have identified two proteins that are responsible for regulating overlapping groups of genes during the development of red blood cells. view more (2007-08-07)
Long-term muscle improvements shown in gene therapy study in mice
Injecting a gene responsible for making a specific protein into a mouse that's used as a model for muscular dystrophy can lead to long-term improvements in the animal's muscle size and strength, a new study shows. view more (2008-03-11)
Researchers identify key gene that may be a marker of breast cancer metastasis
Researchers at Fox Chase Cancer Center have identified an important gene involved in the spread of breast cancer that has developed resistance to long-term estrogen deprivation. view more (2007-04-19)
Treatment to improve degenerating muscle gains strength
A study appearing in Science Translational Medicine puts scientists one step closer to clinical trials to test a gene delivery strategy to improve muscle mass and function in patients with certain degenerative muscle disorders. view more (2009-11-12)
Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model
Rats with erectile dysfunction, or ED, that were injected with a gene therapy vector containing either of two nerve growth factors were able to regain normal function after four weeks. view more (2007-06-04)
Action needed to avoid HIV drug resistance in Africa
We should stop and think about the risks of resistance, and ways of minimising them, before increasing access to antiretroviral therapy in Africa, argue researchers in this week's BMJ. view more (2004-01-29)
AN EYE FOR AN EYE: Using stem cells to treat damaged eyes and a rare skin disorder
Doctors and scientists in Italy have shown how stem cells can be used to treat damaged eyes and, in combination with gene therapy, a rare and debilitating skin disease. view more (2007-10-23)
One shot of gene therapy spreads through brain in animal study
By targeting a site in a mouse brain well connected to other areas, researchers successfully delivered a beneficial gene to the entire brain-after one injection of gene therapy. If these results in animals can be realized in people, researchers may have a potential method for gene therapy to treat a host of rare but devastating congenital human... view more... (2007-10-09)
Research shows promise for potential new gene therapy strategy for muscle-wasting diseases
Investigators in The Research Institute at Nationwide Children's Hospital have identified the role of a protein that could potentially lead to new clinical treatments to combat musculoskeletal diseases, including Duchenne muscular dystrophy (DMD). view more (2008-03-11)
Gene therapy inhibits epilepsy in animals
For the first time, researchers have inhibited the development of epilepsy after a brain insult in animals. By using gene therapy to modify signaling pathways in the brain, neurology researchers found that they could significantly reduce the development of epileptic seizures in rats. view more (2006-11-09)
New genes at work in patients with hereditary lung disease
Researchers at the University of Massachusetts Medical School and the University of Florida in Gainesville have safely given new, functional genes to patients with a hereditary defect that can lead to fatal lung and liver diseases. view more (2009-08-11)
Breathe deep: Which patients could benefit from inhaled steroids in cystic fibrosis?
A specific variation in the glucocorticoid receptor gene is associated with lung disease progression in cystic fibrosis, research published this week in the online open access journal Respiratory Research reveals. view more (2007-11-29)
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