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Evolution is driven by gene regulation
It is not just what's in your genes, it's how you turn them on that accounts for the difference between species - at least in yeast - according to a report by Yale researchers in this week's issue of Science. view more (2007-08-10)
Lithium and bone healing
Researchers have described a novel molecular pathway that may have a critical role in bone healing and have suggested that lithium, which affects this pathway, has the potential to improve fracture healing. view more (2007-07-31)
Scientists synthesize memory in yeast cells
Harvard Medical School researchers have successfully synthesized a DNA-based memory loop in yeast cells, findings that mark a significant step forward in the emerging field of synthetic biology. view more (2007-09-17)
Research elucidates mechanism by which gene expression may be altered in drug addiction
Dr. Judith A. Potashkin, Ph.D. and her colleagues at Rosalind Franklin University of Medicine and Science recently completed a study investigating one of the changes in gene expression that occurs when individuals take addictive drugs. view more (2007-09-05)
UCLA researchers unravel a mystery about DNA
UCLA researchers in collaboration with researchers at Rutgers University have solved longstanding mysteries surrounding DNA transcription, the first step in carrying out instructions contained in our genes. view more (2006-11-17)
Early-stage gene transcription creates access to DNA
A gene contained in laboratory yeast has helped an international team of researchers uncover new findings about the process by which protein molecules bind to control sequences in genes in order to initiate gene expression, according to findings reported in the journal Nature. view more (2008-10-07)
Mouse protein points to memory pill for the old
A drug to aid learning and memory in the elderly may be possible as a result of work being carried out at the Wolfson Institute for Biomedical Research at University College London. A team led by Dr Karl Peter Giese, of the department of learning and memory, is looking at the molecular and cellular mechanisms underlying memory - not so much the... view more... (2000-04-10)
Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
Virginia Commonwealth University researchers studying hemoglobin genes, mutations of which play a role in genetic blood disorders like sickle cell anemia and beta-thalassemia, have identified two proteins that are responsible for regulating overlapping groups of genes during the development of red blood cells. view more (2007-08-07)
Model unravels rules that govern how genes are switched on and off
For years, scientists have struggled to decipher the genetic instruction book that details where and when the 20,000 genes in a human cell will be turned on or off. Different genes operate in each cell type at different times, and this careful orchestration is what ultimately distinguishes a brain cell from a liver or skin cell. view more (2008-12-05)
Gene-transcription machinery seen poised for action, held in check until needed
For some time, scientists have been tracking down the sequence of biochemical steps required to attract and assemble at the head end of a gene the molecular machinery needed to transcribe that gene to put to work the information it encodes. view more (2007-07-26)
CSHL scientists discover new way in which ubiquitin modifies transcriptional machinery to regulate gene activity
During gene transcription - the process inside the nucleus of cells by which DNA, the genetic material, is copied into RNA - a large, ever-changing multiprotein complex is enlisted to assist the DNA-copying enzyme in its challenging job. view more (2008-12-19)
Gene regulates immune cells' ability to harm the body
A recently identified gene allows immune cells to start the self-destructive processes thought to underlie autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis. view more (2009-07-17)
Conaway Lab Demonstrates Mechanism by which Transcription Factor Controls Gene Expression
The Conaway Lab - led by Joan Conaway, Ph.D., and Ron Conaway, Ph.D., Investigators - has published findings that shed light on the role of the much-studied transcription factor YY1 in gene expression. Yong Cai, Ph.D., Research Specialist I, and Jingji Jin, Ph.D., Senior Research Associate, are the paper's coequal first authors. view more (2007-08-28)
Bacteria control how infectious they become, study finds
The results of a new study suggest that bacteria that cause diseases like bubonic plague and serious gastric illness can turn the genes that make them infectious on or off. view more (2007-04-13)
Genetic 'tag team' keeps cells on cycle
By surveying the activity of thousands of genes at several different time points, researchers at the Duke Institute for Genome Sciences & Policy have uncovered new evidence that a network of influential genes act as a kind of genetic tag team to orchestrate one of the most fundamental aspects of all life: the cell cycle. view more (2008-05-08)
Scientists reveal structure of gateways to gene control
Scientists at Penn State University will reveal in the 29 March 2007 issue of the journal Nature the first complete high-resolution map of important structures that control how genes are packaged and regulated throughout an entire genome. view more (2007-03-29)
Molecular alliance that sustains embryonic stem cell state
One of the four ingredients in the genetic recipe that scientists in Japan and the U.S. followed last year to persuade human skin cells to revert to an embryonic stem cell state, is dispensable in ES cells, thanks to the presence of a molecular alliance between a specific group of key proteins known as transcription factors. view more (2008-03-05)
Suicide Gene Combination Targets Breast Cancer
A new 'mix and match' cancer therapy is being unveiled at the British Endocrine Societies meeting in Birmingham today. view more (2000-03-07)
Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
During muscle regeneration, which is a natural response to injury and disease, environmental cues cause adult muscle stem cells (satellite cells) to shift from dormancy to actively building new muscle tissue. view more (2007-12-10)
Scientists Identify Key Roadblock to Gene Expression
A team of scientists has provided, for the first time, a detailed map of how the building blocks of chromosomes, the cellular structures that contain genes, are organized in the fruit fly Drosophila melanogaster. view more (2008-05-09)
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