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Prediction of gene function in mammals
Gene function in mammals can be quickly and reliably predicted using a high-throughput analysis of patterns of RNA expression, according to an article published today in Journal of Biology. This challenges the conventional view that tissue-specificity is the best predictor of function, and could speed up the quest to understand whole genomes, in... view more... (2004-12-02)
Computation to unravel how genes are regulated and shed light on how cells become different
A closer alliance between computational and experimental researchers is needed to make progress towards one of biology's most challenging goals, understanding how epigenetic marks contribute to regulation of gene expression. view more (2008-04-11)
Tool developed to silence genes in specific tissues using RNAi
Researchers at The University of Texas M. D. Anderson Cancer Center say they have jumped a significant hurdle in the use of RNA interference (RNAi), believed by many to be the ultimate tool to both decode the function of individual genes in the human genome and to treat disease. view more (2006-01-17)
Fibroblasts invade at a snail's pace
A transcription factor known to drive the formation of fibroblasts during development also promotes their ability to invade and remodel surrounding tissues, report Rowe et al. in the February 9, 2009 issue of the Journal of Cell Biology. view more (2009-02-02)
Cancer researchers found a new mechanism potentially explaining evolution of signalling pathways
Cancer researchers at the University of Helsinki, in trying to find a novel tumor suppressor gene, instead found an important evolutionary change that occurred in a key developmental signalling pathway. view more (2006-02-08)
An ancient protein balances gene activity and silences foreign DNA in bacteria
Compared to humans, bacteria have a much tidier genome. The tiny microorganisms pack their genes closely together, and don't carry around a lot of extraneous DNA, so-called junk DNA that fills in the gaps between genes. view more (2008-05-16)
Fly with brain tumor may shed light on cancer causing genes
A study showing how the expression of genes changes when the brain tissue of fruit flies becomes cancerous is published this week in BMC Genomics. As the function of many of these genes is conserved across evolution, the researchers expect their results will help us to understand why human brain tumors develop. The causes of brain tumor... view more... (2004-04-14)
Location, location, location: Transcriptional activity and nuclear position
Dr. Mark Groudine (FHCRC) and colleagues report on their surprising characterization of changes in intranuclear organization during murine erythropoiesis. view more (2006-05-18)
FOXO factor promotes survival of oxygen-deprived cancer cells
Scientists report that an evolutionarily conserved transcription factor may have both positive and negative effects on the growth of tumors, depending on whether or not the tumor cells have enough oxygen. view more (2007-12-28)
Study will explore genetics of congenital limb and heart malformations
New research published in the August issue of the Journal of Cell Biology explains for the first time why congenital heart defects so often occur with limb deformities. view more (2006-08-21)
Making sense of antisense microRNAs
Three independent papers in the January 1st issue of G&D report on the discovery of a bidirectionally transcribed microRNA (miRNA) locus in Drosophila. view more (2008-01-02)
Scientists map key landmarks in human genome
Dana-Farber Cancer Institute researchers have developed a powerful method for charting the positions of key gene-regulating molecules called nucleosomes throughout the human genome. view more (2007-01-17)
Genetic variation helps to understand predisposition to schizophrenia
Scientists have provided new insight into how a gene is related to schizophrenia. view more (2007-08-10)
Different but equal: Settling the dosage compensation debate
Independent research papers from Dr. Peter Becker (Munich, Germany) and Dr. Mitzi Kuroda (Boston, MA) in the October 1 issue of Genes & Development delineate the mechanism of X-chromosome dosage compensation in Drosophila. view more (2005-10-03)
New gene silencing pathway found in plants
Biologists at Washington University in St. Louis have made major headway in explaining a mechanism by which plant cells silence potentially harmful genes. view more (2008-11-18)
Pigeons provide clue to solving common problem in heart patients
Through studying pigeons with genetic heart disease, researchers at Wake Forest University School of Medicine have discovered a clue about why some patients' heart vessels are prone to close back up after angioplasty. view more (2006-07-31)
Fox Chase Researchers Uncover One Force Behind the MYC Oncogene in Many Cancers
DLX5, a gene crucial for embryonic development, promotes cancer by activating the expression of the known oncogene, MYC, according to researchers from Fox Chase Cancer Center. view more (2009-07-29)
Jefferson researchers uncover new way nature turns genes on and off
Peering deep within the cells of fruit flies, developmental biologists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia may have discovered a new way that genes are turned on and off during development. view more (2006-12-28)
Enzyme alerts cell's powerful army to repair DNA damage
Scientists know that inside each cell, a little engine called RNA polymerase II does one essential job: It copies instructions from genes in the nucleus that get carried to production units in the rest of the cell to support our daily needs. view more (2007-09-06)
Location matters, even for genes
Moving an active gene from the interior of the nucleus to its periphery can inactivate that gene report scientists from the University of Chicago Medical Center in an article to be published early online Feb.13, 2008, in the journal Nature. view more (2008-02-14)
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