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Huntington's disease study shows animal models on target
An international team of researchers has published a benchmark study showing that gene expression in several animal models of Huntington's Disease (HD) closely resembles that of human HD patients. view more (2007-08-01)
Researchers 'notch' a victory toward new kind of cancer drug
Scientists have devised an innovative way to disarm a key protein considered to be "undruggable," meaning that all previous efforts to develop a drug against it have failed. view more (2009-11-12)
Technique finds gene regulatory sites without knowledge of regulators
A new statistical technique developed by researchers at the University of Illinois allows scientists to scan a genome for specific gene-regulatory regions without requiring prior knowledge of the relevant transcription factors. view more (2009-11-20)
Salk scientists get to the root of plant cell fate
When Robert Burns compared his love to a red, red rose, he definitely wasn't referring to a topless mutant. That's because rather than being topped by a lovely, fragrant bloom, a rose mutant in the gene known as TOPLESS would be crowned by a homely second root. view more (2006-06-09)
Dying of excitement
For neurons, overexcitement is deadly. To avoid this, brain cells must sop up unneeded neurotransmitters from the synapse through membrane-bound transporters. If these transporters fail, neurons and other brain cells get excited to death- a phenomenon that may contribute to brain damage during stroke and Alzheimer's disease. view more (2006-03-06)
When it comes to gene transcription, random pauses aren't quite so random, study finds
Of the thousands of proteins produced in our cells, few are as important as the enzyme RNA polymerase (RNAP), which has the unique ability to faithfully copy genetic information from DNA. view more (2006-06-16)
MIT researcher presents new view of how the cortex forms
A leading neuroscientist at MIT and one from the University of California at San Francisco (UCSF) report in the Nov. 4 special issue of Science dedicated to the brain that the controversy is over: The "protomap" and "protocortex" theories of brain development are dead. view more (2005-11-14)
MicroRNA may have fail-safe role in limb development
A tiny strand of molecules plays a role in how our arms and legs develop and grow-a finding that sheds light on perplexing bits of material once dismissed as genetic "junk," say scientists at the University of Florida and Harvard University. view more (2005-12-02)
Researchers discover new form of cancer gene regulation
The Quaking gene, first described as a mutation in mice that causes rapid tremor, is thought to suppress tumor formation and protect humans from cancer. view more (2005-11-08)
Genes that both extend life and protect against cancer identified
A person is 100 times more likely to get cancer at age 65 than at age 35. But new research reported today in the journal "Nature Genetics" identifies naturally occurring processes that allow many genes to both slow aging and protect against cancer in the much-studied C. elegans roundworm. view more (2007-10-15)
Neural stem cell gene plays crucial role in eye development
Scientists at the University of North Carolina at Chapel Hill have demonstrated that normal development of the eye requires the right amount of a neural stem cell gene be expressed at the right time and place. view more (2006-05-16)
'Junk' DNA proves functional
In a paper published in Genome Research on Nov. 4, scientists at the Genome Institute of Singapore (GIS) report that what was previously believed to be "junk" DNA is one of the important ingredients distinguishing humans from other species. view more (2008-11-05)
A tiny protein plays a big role in DNA repair
Two of DNA's worst enemies, ultraviolet light and chemical carcinogens, can wreak havoc on the molecule by mutating individual nucleotides or changing its physical structure. view more (2006-05-09)
Mean new microRNA data analysis method gives sharper results
Our understanding of the importance of microRNAs in regulating gene expression is expanding, and with it our requirement for robust methods to measure their expression levels. view more (2009-06-16)
Researchers discover gene for branchio-oculo-facial syndrome
In a collaborative effort, researchers from Boston University School of Medicine (BUSM) have discovered that deletions or mutations within the TFAP2A gene (Activating Enhancer-Binding Protein) result in the distinctive clefting disorder Branchio-Oculo-Facial syndrome (BOFS). view more (2008-04-24)
Scientists unlock solid tumor treatment genetic secrets
A biochemical mechanism that cells use to cope with hypoxia (lack of oxygen) actually cooperates with a less well-known mechanism that helps increase the expression of those hypoxia-sensitive genes. view more (2005-12-02)
A Morse code for human cells
Morse code is a simple, effective and clear method of communication and now scientists believe that cells in our body may also be using patterns of signals to switch genes on and off. The discovery may have major implications for the pharmaceutical industry as the signalling molecules that are targeted by drugs may have more than one purpose. The... view more... (2005-01-06)
MIT, BU engineer cellular circuits that count events
MIT and Boston University engineers have designed cells that can count and "remember" cellular events, using simple circuits in which a series of genes are activated in a specific order. view more (2009-05-29)
Another gene rearrangement involved in prostate cancer identified
Researchers at the University of Michigan Medical School have identified a third gene involved in prostate cancer, expanding their groundbreaking announcement, published last October in Science, that the majority of prostate cancers carry a malignancy-inducing fusion of genes never before seen in solid tumors. view more (2006-04-04)
How embryonic stem cells maintain their identity
Two studies in the April 21, 2006 Cell report new details of the "genetic program" that affords embryonic stem cells the flexibility to give rise to any cell type in the body. view more (2006-04-21)
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