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RNA emerges from DNA's shadow
RNA, the transporter of genetic information within the cell, has emerged from the shadow of DNA to become one of the hottest research areas of molecular biology, with implications for many diseases as well as understanding of evolution. view more (2008-07-11)
Schizophrenia and bipolar disorder could have similar genetic causes (pp 758, 798)
Issue 6 September 2003 Embargoed 0001 h (London time) 5 September 2003. Authors of a study in this week's issue of THE LANCET provide strong evidence that schizophrenia and bipolar disorder have a similar genetic cause arising from reduced expression of genes responsible for myelin development of the central nervous system. Schizophrenia and... view more... (2003-09-03)
Free shopping in a virtual bazaar of gene regulation data
An international team has opened a virtual bazaar, called PAZAR, which allows biologists to share information about gene regulation through individually managed 'boutiques' (data collections). view more (2007-10-04)
Mayo Clinic Researchers Find That Protein Believed to Protect Against Cancer Has a Mr. Hyde Side
In a biological rendition of fiction's Strange Case of Dr. Jekyll and Mr. Hyde, researchers from the Mayo Clinic campus in Florida and Harvard Medical School have found that a protein thought to protect against cancer development can actually spur the spread of tumors. view more (2009-09-04)
Researchers reveal repressor protein blocks neural stem cell development
A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons. view more (2007-10-11)
Scientists discover a genetic code for organizing DNA within the nucleus
DNA - the long, thin molecule that carries our hereditary material - is compressed around protein scaffolding in the cell nucleus into tiny spheres called nucleosomes. view more (2006-07-20)
Protein amplification in melanoma is possible drug target
Researchers have pinpointed specific gene and protein over-production in metastatic melanoma, pointing the way to a possible new drug target, according to a study published in Nature July 7. view more (2005-07-11)
Disrupted genetic regulation causes common disturbance in metabolism of fat
The disease familial combined hyperlipidemia (FCH) is a common cause of disturbed metabolism of fat and early heart attacks. Uppsala University scientists have now developed a pioneering method and can show for the first time what genes are regulated by the gene USF1, which is known to cause the disease. view more (2008-02-06)
Master genetic switch found for chronic pain
In experiments with mice, researchers have found that eliminating what appears to be a master genetic switch for the development of pain-sensing neurons knocks out the animals' response to "neuropathic pain." view more (2006-01-26)
Tolerance to inhalants may be caused by changes in gene expression
Changes in the expression of genes may be the reason why people who abuse inhalants, such as spray paint or glue, quickly develop a tolerance, biologists at The University of Texas at Austin have discovered. view more (2007-10-18)
Complexity constrains evolution of human brain genes
Despite the explosive growth in size and complexity of the human brain, the pace of evolutionary change among the thousands of genes expressed in brain tissue has actually slowed since the split, millions of years ago, between human and chimpanzee. view more (2006-12-26)
Brown Cancer Biologists Identify Major Player in Cell Growth
When cells go about the business of dividing, they can get sidelined. Maybe there aren't enough nutrients. Maybe there aren't the right signals to resume multiplying. Either way, cells go quiet. view more (2007-02-07)
Transcription factor protein's role in cell death, neurodegeneration and schizophrenia
Researchers at the University of Pennsylvania School of Medicine discovered that a protein called Elk-1 interacts with mitochondria, the energy storehouse of a cell, suggesting that this protein -— typically active in the nucleus — could play a role in cell death and mitochondria-related diseases such as neurodegeneration and... view more... (2006-06-08)
Mouse gene suppresses Alzheimer's plaques and tangles
Investigators at Burnham Institute for Medical Research (Burnham) and colleagues have identified a novel mouse gene (Rps23r1) that reduces the accumulation of two toxic proteins that are major players in Alzheimer's disease: amyloid beta and tau. view more (2009-11-12)
Drug not effective in preventing bypass vein clogging
A new drug, edifoligide, designed to prevent the clogging of veins used in coronary bypass surgery was no more effective than a placebo, according to the results of a Phase III clinical trial led by researchers at Duke Clinical Research Institute (DCRI). view more (2005-11-14)
Mayo Clinic Researchers Find Experimental Therapy Turns on Tumor Suppressor Gene in Cancer Cells
Researchers at Mayo Clinic have found that the experimental drug they are testing to treat a deadly form of thyroid cancer turns on a powerful tumor suppressor capable of halting cell growth. Few other cancer drugs have this property, they say. view more (2009-01-20)
Scientists Shed Light on Long-Distance Signaling in Developing Neurons
A longstanding puzzle in neurodevelopment may have yielded up a key secret. A team led by scientists at Weill Cornell Medical College says they have determined how events at the very tips of the developing neuron's long, skinny axon affect gene transcription back in the cell's distant nucleus. view more (2008-02-20)
The pen may be mightier than the keyboard
When it comes to writing the pen apparently is mightier than the computer keyboard. Second, fourth and sixth grade children with and without handwriting disabilities were able to write more and faster when using a pen than a keyboard to compose essays, according to new research. view more (2009-09-17)
Remote control for human growth hormone gene expression
Researchers at the University of Pennsylvania School of Medicine recently discovered a novel mechanism that works over an extensive genomic distance and controls the expression of human growth hormone (hGH) in the pituitary gland. view more (2006-08-14)
'Gateway' gene discovered for brain cancer
Researchers have discovered that the same genetic regulator that triggers growth of stem cells during brain development also plays a central role in the development of the lethal brain cancer malignant glioma. view more (2007-02-15)
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