Glutamate Current Events | Glutamate News
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New perspective on brain function now possible
A newly started research collaboration between Karolinska Institutet and AstraZeneca has already generated results. For the first time, the conditions have been created to study one of the brain's most important neurotransmission systems - the glutamate system - in living people. view more (2007-05-30)
Glutamate: Too much of a good thing in schizophrenia?
Is schizophrenia a disorder of glutamate hyperactivity or hypoactivity? While the predominant hypothesis for many years was that schizophrenia was a glutamate deficit disorder, there is growing evidence of glutamate hyperactivity as well. view more (2008-10-28)
Hepatic encephalopathy and prehepatic portal hypertension rat model
A research article to be published June 21, 2009 in the World Journal of Gastroenterology addresses this question. The research team lead by Dr. Gabriela Beatriz Acosta, observed that the activity of GS was increased in the hippocampus in PH rats. view more (2009-06-29)
Bisexual fruit flies show new role for neurochemical
Fruit flies' ability to discern one sex from another may depend on the number of receptors on the surface of nerve cells, and the number of receptors is controlled by levels of a ubiquitous brain chemical, University of Illinois at Chicago researchers have found. view more (2007-01-04)
Enzyme defect leads to hyperinsulinism
A recent study in the Journal of Biological Chemistry confirms that mutations in an enzyme called glutamate dehydrogenase can cause congenital hyperinsulinism. view more (2006-05-25)
Dying of excitement
For neurons, overexcitement is deadly. To avoid this, brain cells must sop up unneeded neurotransmitters from the synapse through membrane-bound transporters. If these transporters fail, neurons and other brain cells get excited to death- a phenomenon that may contribute to brain damage during stroke and Alzheimer's disease. view more (2006-03-06)
Receptor activated exclusively by glutamate discovered on tongue
One hundred years ago, Kikunae Ikeda discovered the flavour-giving properties of glutamate, a non essential amino acid traditionally used to enhance the taste of many fermented or ripe foods, such as ripe tomatoes or cheese. New research now reveals that the tongue has a receptor that is exclusively activated by glutamate. view more (2009-10-09)
Pain in fibromyalgia is linked to changes in brain molecule
Researchers at the University of Michigan Health System have found a key linkage between pain and a specific brain molecule, a discovery that lends new insight into fibromyalgia, an often-baffling chronic pain condition. view more (2008-03-11)
CSHL links activity in brain synapses and developmental abnormalities with schizophrenia gene
Cold Spring Harbor Laboratory (CSHL) researchers have identified a function of neuregulin1 (NRG1), a gene previously linked to schizophrenia but whose role in the disease was unknown. view more (2007-05-25)
Cell's split personality is a major discovery into neurological diseases
Researchers at the Université de Montreal (UdeM) and the Montreal Neurological Institute (MNI), McGill University have discovered that cells which normally support nerve cell (neuron) survival also play an active and major role in the death of neurons in the eye. view more (2009-05-08)
Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
Carnegie Mellon University chemists have solved a decade-long molecular mystery that could eventually help scientists develop drug therapies to treat a variety of disorders, including epilepsy and Alzheimer's disease. view more (2007-08-22)
Medication eases obsessive-compulsive symptoms
A medication used to ease symptoms of amyotrophic lateral sclerosis, or Lou Gehrig's disease, also is helpful in treating people with treatment-resistant obsessive-compulsive disorder (OCD), according to a pilot study at Yale School of Medicine. view more (2005-08-01)
Matrix fragments trigger fatal excitement
Shredded extracellular matrix (ECM) is toxic to neurons. Chen et al. reveal a new mechanism for how ECM demolition causes brain damage. The study will appear in the December 29, 2008 issue of The Journal of Cell Biology (www.jcb.org). view more (2008-12-30)
Common treatment for methamphetamine overdose may damage brain cells
A common antipsychotic drug used in emergency rooms to treat methamphetamine overdose damages nerve cells in an area of the brain known to regulate movement, a new study shows. view more (2007-05-30)
Pitt research identifies new target in brain for treating schizophrenia
Research from the University of Pittsburgh could expand the options for controlling schizophrenia by identifying a brain region that responds to more than one type of antipsychotic drug. view more (2008-11-06)
La mouche comme mode'le pour étudier les effets neurotoxiques du glutamate chez l'homme
La drosophile (ou mouche du vinaigre) peut servir de mode'le pour comprendre le rôle des neurotransmetteurs excitateurs comme le glutamate dans les dommages subis par le cerveau humain lors d'accidents vasculaires et dans certaines maladies neurodégénératives. C'est ce que vient de montrer une équipe du CNRS... view more... (2004-04-06)
Brain cell research opens way to stroke treatment
New ways of limiting the damage caused by strokes, through reducing the energy demands on brain cells, may come about from work being carried out in the Wolfson Institute of Biomedical Research at University College London. Professor John Garthwaite and colleagues, from the department of neuroscience, are looking at how brain cells talk to each... view more... (2000-04-10)
Potential new approach to treat cognitive impairments in schizophrenia
A new study reports important evidence for a potential new treatment approach for those diagnosed with schizophrenia. Schizophrenia is considered one of the most devastating of the major psychiatric disorders, which has three distinct facets, often referred to as "positive" (hallucinations, delusions), "negative" (blunted... view more... (2007-09-25)
Structure of important neurotransmitter regulator determined
Researchers from Virginia Tech and the Brookhaven National Laboratory have solved the structure of an enzyme that is critical in the regulation of the neurotransmitter system in the human brain. view more (2008-02-04)
Drosophila drug screen for fragile X syndrome finds promising compounds and potential drug targets
Scientists using a new drug screening method in Drosophila (fruit flies), have identified several drugs and small molecules that reverse the features of fragile X syndrome -- a frequent form of mental retardation and one of the leading known causes of autism. view more (2008-03-10)
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