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Protein identified that turns off HIV-fighting T cells
In HIV-infected patients the body's immune system is unable to fight off the virus. A new study to be published online on November 10th in the Journal of Experimental Medicine shows that T cells in HIV-infected individuals express a protein called TIM-3, which inactivates their virus killing capacity.   view more (2008-11-10)

FURTHER STEPS TOWARDS A VACCINE AGAINST HIV
For white blood cells in the human body to be infected by the HIV virus, proteins in the virus must be allowed to interact with a number of different components on the surface of the white blood cell. Ideally anti-HIV preventive therapy or vaccines would prevent several of these interactions taking place and would, therefore, reduce the likelihood... view more... (1999-03-11)

Waking up dormant HIV
HAART (highly active anti-retroviral therapy) has emerged as an extremely effective HIV treatment that keeps virus levels almost undetectable; however, HAART can never truly eradicate the virus as some HIV always remains dormant in cells.   view more (2009-03-17)

Researchers discover gut tissue to be a major reservoir harboring HIV
UCLA researchers have found the human gut to be a major reservoir harboring the HIV virus - holding almost twice as much as a person's blood.   view more (2006-08-28)

U of M identifies cell line that is resistant to retroviruses, including HIV
Researchers at the University of Minnesota have identified a protein that enables viruses such as HIV to infect cells and spread through the body.   view more (2006-10-18)

How breastfeeding affects HIV transmission
Mother to child transmission of HIV accounts for a large proportion of HIV infections in children, with many infected as a result of breastfeeding, which requires transfer of the virus across mucosal barriers.   view more (2005-10-21)

Researchers link specific antibody presence to prevention of mother-to-baby HIV transmission
Exploring why some HIV-positive mothers transmit the virus in utero to their babies while others don't, researchers from the UCLA AIDS Institute and Los Alamos National Laboratory studied 38 infant-mother pairs in the UCLA arm of the Los Angeles Pediatric AIDS Consortium.   view more (2006-07-12)

Immune exhaustion in HIV infection
As HIV disease progresses in a person infected with the HIV virus, a group of cells in the immune system, the CD8+ T lymphocytes, become "exhausted," losing many of their abilities to kill other cells infected by the virus.   view more (2008-05-06)

Sperm may play leading role in spreading HIV
Sperm, and not just the fluid it bathes in, can transmit HIV to macrophages, T cells, and dendritic cells (DCs), report a team led by Ana Ceballos at the University of Buenos Aires in Argentina.   view more (2009-10-26)

Vaccine to cope with viral diversity in HIV
The ability of HIV-1 to develop high levels of genetic diversity and acquire mutations to escape immune pressures contributes to our difficulties in producing a vaccine.   view more (2007-04-27)

HIV isolate from Kenya provides clues for vaccine design
Two simple changes in its outer envelope protein could render the AIDS virus vulnerable to attack by the immune system, according to research from Kenya and the Fred Hutchinson Cancer Research Center published in PLoS Medicine.   view more (2008-01-03)

NIAID media availability: New strategy proposed for designing antibody-based HIV vaccine
Most vaccines that protect against viruses generate infection-fighting proteins called antibodies that either block infection or help eliminate the virus before it can cause disease.   view more (2009-06-15)

HIV-1 : RECOMBINATION BETWEEN TWO STRAINSFROM WIDELY DISTANT GROUPS
Scientists have known for a long time that the AIDS virus is genotypically highly variable. Two main types of the virus exist: HIV-1 and HIV-2. HIV-1, the most widespread throughout the world, can be divided into three groups (M, N and O) each of which has different genetic characteristics. Within group M, which gathers together the most frequent... view more... (2000-03-09)

How HIV vaccine might have increased odds of infection
In September 2007, a phase II HIV-1 vaccine trial was abruptly halted when researchers found that the vaccine may have promoted, rather than prevented, HIV infection.   view more (2008-11-03)

MicroRNAs help control HIV life cycle
Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specific microRNAs (non-coding RNAs that interfere with gene expression) reduce HIV replication and infectivity in human T-cells.   view more (2009-06-26)

Human testis harbors HIV-1 in resident immune cells
Researchers have demonstrated HIV replication within resident immune cells of the testis, providing an explanation for the persistence of virus in semen even after effective highly active antiretroviral therapy.   view more (2006-11-27)

MU scientists 'see' how HIV matures into an infection
After improving the sensitivity of nuclear magnetic resonance (NMR), researchers at the University of Missouri actually watched the HIV-1 protease mature from an inactive form into an active infection. This process has never been directly visualized before. The findings appear today in the journal Nature.   view more (2008-10-02)

Scientists glimpse a rare human antibody which protects against AIDS
Scientists have obtained their first detailed glimpse of a rare antibody, called b12, which is capable of inactivating many different strains of HIV, the virus which causes AIDS. A crystal structure of b12 has been determined by scientists working at The Scripps Research Institute, California, and the Glycobiology Institute at Oxford University,... view more... (2001-08-08)

Researchers have discovered a gene that can block the spread of HIV
A team of researchers at the University of Alberta, including a scientist at the University of Pennsylvania, have discovered a gene that is able to block HIV, and thought to in turn prevent the onset of AIDS.   view more (2008-02-29)

Protein that provides innate defense against HIV could lead to new treatments
By identifying a protein that restricts the release of HIV-1 virus from human cells, scientists believe they may be closer to identifying new approaches to treatment. The research is published in the advance online edition of Nature Medicine.   view more (2008-05-27)
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