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AFRICAN HIV-1 EPIDEMIC NOT CAUSED BY MORE INFECTIOUS VIRAL SUBTYPE (p 1149)
The explosive HIV-1 epidemic in sub-Saharan Africa is unlikely to be the result of a viral subtype with increased infectivity, according to the results of a study published in this week’s issue of THE LANCET. The HIV-1 epidemic in eastern and southern sub-Saharan Africa is mainly caused by HIV-1 subtypes A, C, and D, whereas those in the USA... view more... (2001-04-11)
INCREASED RISK OF TUBERCULOSIS RECURRENCE IN PEOPLE WITH HIV-1 INFECTION (pp 1470, 1488)
People with HIV-1 infection are at an increased risk of recurrent tuberculosis, and could benefit from preventative treatment after the first episode of the disease, concludes research published in this week's issue of THE LANCET. Patients with HIV-1 infection respond well to treatment for active tuberculosis, but whether such patients are at... view more... (2000-10-25)
New drug candidate against HIV developed in Sweden
As a part of a research collaboration, scientists at the Sahlgrenska Academy at Göteborg University, Sweden, have developed a new drug candidate against HIV-infection. view more (2005-06-30)
New publication presents latest in HIV/TB treatment, research
With HIV infection driving a deadly resurgence of tuberculosis (TB), a new publication provides up-to-date recommendations for clinicians facing the many challenges of treating patients with both of these two complex diseases. view more (2007-07-17)
Exhaustion of HIV-specific T cells may be caused by chronic exposure to virus
The "exhaustion" of immune cells that target HIV appears to result from chronic exposure to the virus, specifically exposure to the particular protein segments targeted by the pathogen-killing HIV-specific CD8 T cells. view more (2008-05-06)
COST-EFFECTIVENESS ASSESSMENTS IMPORTANT FOR HIV RESPONSE IN AFRICA (p 1635)
A systematic review in this week's issue of THE LANCET highlights the importance of cost-effectiveness evaluation to identify realistic intervention programmes to tackle HIV/AIDS in Africa. HIV/AIDS accounts for around 20% of all deaths in Africa. The cost-effectiveness of interventions is important as African governments face difficult choices... view more... (2002-05-08)
Study offers insights into failed HIV-1 vaccine trial
Following the disbandment of the STEP trial to test the efficacy of the Merck HIV-1 vaccine candidate in 2007, the leading explanation for why the vaccine was ineffective - and may have even increased susceptibility to acquiring the virus - centered on the hypothesis that high levels of baseline Ad5-specific neutralizing antibodies may have... view more... (2009-07-21)
Unsafe injections rejected as major source of HIV infection in Africa (p 482)
A recent theory proposing that unsafe injections are a major cause of HIV-1 infection in sub-Saharan Africa is rejected by authors of an article in this week's issue of THE LANCET. During the past year, a group (D Gisselquist and colleagues) has argued that unsafe injections are a major mode of HIV-1 transmission in sub-Saharan Africa, with up to... view more... (2004-02-04)
U of M researchers determine structure of protein that mutates DNA of the AIDS virus HIV-1
Understanding the structure of proteins involved in inhibiting HIV-1 infection could help in the battle against AIDS, and University of Minnesota researchers have taken a crucial step in that direction. view more (2008-02-21)
Sperm may play leading role in spreading HIV
Sperm, and not just the fluid it bathes in, can transmit HIV to macrophages, T cells, and dendritic cells (DCs), report a team led by Ana Ceballos at the University of Buenos Aires in Argentina. view more (2009-10-26)
The Role Of Sexually Transmitted Diseases, Malaria, And Tuberculosis On The Hiv-1/Aids Epidemic In Africa (p 2177)
The effect of HIV-1 on other infectious diseases in Africa is an increasing public health concern. In a review in this week's issue of THE LANCET, Elizabeth Corbett from the London School of Hygiene and Tropical Medicine, UK, and the Harare Biomedical Research and Training Institute, Zimbabwe, and colleagues describe the role that three major... view more... (2002-06-19)
Hopkins study suggests commercially available antibiotic may help fight dementia in HIV patients
An antibiotic commonly used to treat a variety of serious infections may also help prevent dementia in HIV patients, according to a test-tube study of human brain cells by Johns Hopkins University School of Medicine neurologist Jeffrey Rumbaugh, M.D., Ph.D. view more (2006-04-06)
Research uncovers signaling pathways related to brain-immune system links
New research on signaling pathways in immune cells bolsters evidence of connections between the central nervous system and the immune system. view more (2006-05-16)
Rapid HIV testing in the ER boosts diagnoses, screening
One in every 50 people screened for a suspected sexually transmitted infection (STI) in the Emergency Department at Henry Ford Hospital was found to be infected with HIV using a rapid blood sample screening test. view more (2008-10-27)
Virological evidence cannot prove transmission in HIV criminal cases
Virological evidence cannot prove transmission in HIV criminal cases, warn experts in this week's BMJ. view more (2007-09-07)
Timely Antiretroviral Therapy Essential For Best Prognosis In People With HIV-1 Infection (p 119)
Authors of an international study in this week's issue of THE LANCET highlight how timely treatment with highly-active antiretroviral therapy (HAART) can substantially improve the three-year prognosis for people with HIV-1 infection. HAART became widespread in more-developed countries in 1996. However, there is insufficient data from individual... view more... (2002-07-10)
Expansion of monocyte subset could serve as a biomarker for HIV progressions
An increase in the CD163+/CD16+ monocyte subset could be a biomarker for the progression of HIV disease, according to researchers at Temple University. view more (2008-03-28)
Anti-HIV gel proven safe, tolerable for women
An experimental anti-HIV gel is safe for women to use on a daily basis, according to researchers at the University of Alabama at Birmingham (UAB) and the University of Pittsburgh School of Medicine. view more (2008-02-26)
Penn-Wistar team gains insight into HIV vaccine failure
A team of researchers from The Wistar Institute and the University of Pennsylvania reports new evidence refuting a popular hypothesis about the highly publicized failure in 2007 of the Merck STEP HIV vaccine study that cast doubt on the feasibility of HIV-1 vaccines. view more (2009-07-21)
Genetic variation increases HIV risk in Africans
A genetic variation which evolved to protect people of African descent against malaria has now been shown to increase their susceptibility to HIV infection by up to 40 per cent, according to new research. Conversely, the same variation also appears to prolong survival of those infected with HIV by approximately two years. view more (2008-07-17)
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